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An open science study of ageing in companion dogs

Kate E. Creevy, Joshua M. Akey, Matt Kaeberlein and Daniel E. L. Promislow ()
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Kate E. Creevy: Texas A&M University College of Veterinary Medicine & Biomedical Sciences
Joshua M. Akey: Princeton University
Matt Kaeberlein: University of Washington School of Medicine
Daniel E. L. Promislow: University of Washington School of Medicine

Nature, 2022, vol. 602, issue 7895, 51-57

Abstract: Abstract The Dog Aging Project is a long-term longitudinal study of ageing in tens of thousands of companion dogs. The domestic dog is among the most variable mammal species in terms of morphology, behaviour, risk of age-related disease and life expectancy. Given that dogs share the human environment and have a sophisticated healthcare system but are much shorter-lived than people, they offer a unique opportunity to identify the genetic, environmental and lifestyle factors associated with healthy lifespan. To take advantage of this opportunity, the Dog Aging Project will collect extensive survey data, environmental information, electronic veterinary medical records, genome-wide sequence information, clinicopathology and molecular phenotypes derived from blood cells, plasma and faecal samples. Here, we describe the specific goals and design of the Dog Aging Project and discuss the potential for this open-data, community science study to greatly enhance understanding of ageing in a genetically variable, socially relevant species living in a complex environment.

Date: 2022
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DOI: 10.1038/s41586-021-04282-9

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