Unwinding the mutational signatures of a DNA topoisomerase enzyme

Ammal Abbasi and Ludmil B. Alexandrov ()

Nature, 2022, vol. 602, issue 7898, 580-581

Abstract: Certain patterns of mutations occur frequently in cancer. The culprit behind one mutational signature is now shown to be a cellular enzyme with the mundane role of relieving stress in supercoiled DNA.

Keywords: Cancer; Molecular biology (search for similar items in EconPapers)
Date: 2022
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DOI: 10.1038/d41586-022-00301-5

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