Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron

Juan Manuel Carreño, Hala Alshammary, Johnstone Tcheou, Gagandeep Singh, Ariel J. Raskin, Hisaaki Kawabata, Levy A. Sominsky, Jordan J. Clark, Daniel C. Adelsberg, Dominika A. Bielak, Ana Silvia Gonzalez-Reiche, Nicholas Dambrauskas, Vladimir Vigdorovich, Komal Srivastava, D. Noah Sather, Emilia Mia Sordillo (), Goran Bajic (), Harm Bakel (), Viviana Simon () and Florian Krammer ()
Additional contact information
Juan Manuel Carreño: Icahn School of Medicine at Mount Sinai (ISMMS)
Hala Alshammary: Icahn School of Medicine at Mount Sinai (ISMMS)
Johnstone Tcheou: Icahn School of Medicine at Mount Sinai (ISMMS)
Gagandeep Singh: Icahn School of Medicine at Mount Sinai (ISMMS)
Ariel J. Raskin: Icahn School of Medicine at Mount Sinai (ISMMS)
Hisaaki Kawabata: Icahn School of Medicine at Mount Sinai (ISMMS)
Levy A. Sominsky: Icahn School of Medicine at Mount Sinai (ISMMS)
Jordan J. Clark: Icahn School of Medicine at Mount Sinai (ISMMS)
Daniel C. Adelsberg: Icahn School of Medicine at Mount Sinai (ISMMS)
Dominika A. Bielak: Icahn School of Medicine at Mount Sinai (ISMMS)
Ana Silvia Gonzalez-Reiche: ISMMS
Nicholas Dambrauskas: University of Washington
Vladimir Vigdorovich: University of Washington
Komal Srivastava: Icahn School of Medicine at Mount Sinai (ISMMS)
D. Noah Sather: University of Washington
Emilia Mia Sordillo: ISMMS
Goran Bajic: Icahn School of Medicine at Mount Sinai (ISMMS)
Harm Bakel: ISMMS
Viviana Simon: Icahn School of Medicine at Mount Sinai (ISMMS)
Florian Krammer: Icahn School of Medicine at Mount Sinai (ISMMS)

Nature, 2022, vol. 602, issue 7898, 682-688

Abstract: Abstract The Omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially identified in November 2021 in South Africa and Botswana, as well as in a sample from a traveller from South Africa in Hong Kong1,2. Since then, Omicron has been detected globally. This variant appears to be at least as infectious as Delta (B.1.617.2), has already caused superspreader events3, and has outcompeted Delta within weeks in several countries and metropolitan areas. Omicron hosts an unprecedented number of mutations in its spike gene and early reports have provided evidence for extensive immune escape and reduced vaccine effectiveness2,4–6. Here we investigated the virus-neutralizing and spike protein-binding activity of sera from convalescent, double mRNA-vaccinated, mRNA-boosted, convalescent double-vaccinated and convalescent boosted individuals against wild-type, Beta (B.1.351) and Omicron SARS-CoV-2 isolates and spike proteins. Neutralizing activity of sera from convalescent and double-vaccinated participants was undetectable or very low against Omicron compared with the wild-type virus, whereas neutralizing activity of sera from individuals who had been exposed to spike three or four times through infection and vaccination was maintained, although at significantly reduced levels. Binding to the receptor-binding and N-terminal domains of the Omicron spike protein was reduced compared with binding to the wild type in convalescent unvaccinated individuals, but was mostly retained in vaccinated individuals.

Date: 2022
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DOI: 10.1038/s41586-022-04399-5

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