A single-cell atlas of human and mouse white adipose tissue

Margo P. Emont, Christopher Jacobs, Adam L. Essene, Deepti Pant, Danielle Tenen, Georgia Colleluori, Angelica Vincenzo, Anja M. Jørgensen, Hesam Dashti, Adam Stefek, Elizabeth McGonagle, Sophie Strobel, Samantha Laber, Saaket Agrawal, Gregory P. Westcott, Amrita Kar, Molly L. Veregge, Anton Gulko, Harini Srinivasan, Zachary Kramer, Eleanna Filippis, Erin Merkel, Jennifer Ducie, Christopher G. Boyd, William Gourash, Anita Courcoulas, Samuel J. Lin, Bernard T. Lee, Donald Morris, Adam Tobias, Amit V. Khera, Melina Claussnitzer, Tune H. Pers, Antonio Giordano, Orr Ashenberg, Aviv Regev, Linus T. Tsai and Evan D. Rosen ()
Additional contact information
Margo P. Emont: Beth Israel Deaconess Medical Center
Christopher Jacobs: Beth Israel Deaconess Medical Center
Adam L. Essene: Beth Israel Deaconess Medical Center
Deepti Pant: Beth Israel Deaconess Medical Center
Danielle Tenen: Beth Israel Deaconess Medical Center
Georgia Colleluori: Marche Polytechnic University
Angelica Vincenzo: Marche Polytechnic University
Anja M. Jørgensen: University of Copenhagen
Hesam Dashti: Broad Institute of MIT and Harvard
Adam Stefek: Broad Institute of MIT and Harvard
Elizabeth McGonagle: Broad Institute of MIT and Harvard
Sophie Strobel: Broad Institute of MIT and Harvard
Samantha Laber: Broad Institute of MIT and Harvard
Saaket Agrawal: Broad Institute of MIT and Harvard
Gregory P. Westcott: Beth Israel Deaconess Medical Center
Amrita Kar: Beth Israel Deaconess Medical Center
Molly L. Veregge: Beth Israel Deaconess Medical Center
Anton Gulko: Beth Israel Deaconess Medical Center
Harini Srinivasan: Beth Israel Deaconess Medical Center
Zachary Kramer: Beth Israel Deaconess Medical Center
Eleanna Filippis: Diabetes and Metabolism
Erin Merkel: Beth Israel Deaconess Medical Center
Jennifer Ducie: Beth Israel Deaconess Medical Center
Christopher G. Boyd: Beth Israel Deaconess Medical Center
William Gourash: University of Pittsburgh Medical Center
Anita Courcoulas: University of Pittsburgh Medical Center
Samuel J. Lin: Beth Israel Deaconess Medical Center
Bernard T. Lee: Beth Israel Deaconess Medical Center
Donald Morris: Beth Israel Deaconess Medical Center
Adam Tobias: Beth Israel Deaconess Medical Center
Amit V. Khera: Broad Institute of MIT and Harvard
Melina Claussnitzer: Broad Institute of MIT and Harvard
Tune H. Pers: University of Copenhagen
Antonio Giordano: Marche Polytechnic University
Orr Ashenberg: Broad Institute of MIT and Harvard
Aviv Regev: Broad Institute of MIT and Harvard
Linus T. Tsai: Beth Israel Deaconess Medical Center
Evan D. Rosen: Beth Israel Deaconess Medical Center

Nature, 2022, vol. 603, issue 7903, 926-933

Abstract: Abstract White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.

Date: 2022
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DOI: 10.1038/s41586-022-04518-2

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