Brain charts for the human lifespan

Bethlehem, R. A. I.; Seidlitz, J.; White, S. R.; Vogel, J. W.; Anderson, K. M.; Adamson, C.; Adler, S.; Alexopoulos, G. S.; Anagnostou, E.; Areces-Gonzalez, A.; Astle, D. E.; Auyeung, B.; Ayub, M.; Bae, J.; Ball, G.; Baron-Cohen, S.; Beare, R.; Bedford, S. A.; Benegal, V.; Beyer, F.; Blangero, J.; Cábez, M. Blesa; Boardman, J. P.; Borzage, M.; Bosch-Bayard, J. F.; Bourke, N.; Calhoun, V. D.; Chakravarty, M. M.; Chen, C.; Chertavian, C.; Chetelat, G.; Chong, Y. S.; Cole, J. H.; Corvin, A.; Costantino, M.; Courchesne, E.; Crivello, F.; Cropley, V. L.; Crosbie, J.; Crossley, N.; Delarue, M.; Delorme, R.; Desrivieres, S.; Devenyi, G. A.; Biase, M. A.; Dolan, R.; Donald, K. A.; Donohoe, G.; Dunlop, K.; Edwards, A. D.; Elison, J. T.; Ellis, C. T.; Elman, J. A.; Eyler, L.; Fair, D. A.; Feczko, E.; Fletcher, P. C.; Fonagy, P.; Franz, C. E.; Galan-Garcia, L.; Gholipour, A.; Giedd, J.; Gilmore, J. H.; Glahn, D. C.; Goodyer, I. M.; Grant, P. E.; Groenewold, N. A.; Gunning, F. M.; Gur, R. E.; Gur, R. C.; Hammill, C. F.; Hansson, O.; Hedden, T.; Heinz, A.; Henson, R. N.; Heuer, K.; Hoare, J.; Holla, B.; Holmes, A. J.; Holt, R.; Huang, H.; Im, K.; Ipser, J.; Jack, C. R.; Jackowski, A. P.; Jia, T.; Johnson, K. A.; Jones, P. B.; Jones, D. T.; Kahn, R. S.; Karlsson, H.; Karlsson, L.; Kawashima, R.; Kelley, E. A.; Kern, S.; Kim, K. W.; Kitzbichler, M. G.; Kremen, W. S.; Lalonde, F.; Landeau, B.; Lee, S.; Lerch, J.; Lewis, J. D.; Li, J.; Liao, W.; Liston, C.; Lombardo, M. V.; Lv, J.; Lynch, C.; Mallard, T. T.; Marcelis, M.; Markello, R. D.; Mathias, S. R.; Mazoyer, B.; McGuire, P.; Meaney, M. J.; Mechelli, A.; Medic, N.; Misic, B.; Morgan, S. E.; Mothersill, D.; Nigg, J.; Ong, M. Q. W.; Ortinau, C.; Ossenkoppele, R.; Ouyang, M.; Palaniyappan, L.; Paly, L.; Pan, P. M.; Pantelis, C.; Park, M. M.; Paus, T.; Pausova, Z.; Paz-Linares, D.; Binette, A. Pichet; Pierce, K.; Qian, X.; Qiu, J.; Qiu, A.; Raznahan, A.; Rittman, T.; Rodrigue, A.; Rollins, C. K.; Romero-Garcia, R.; Ronan, L.; Rosenberg, M. D.; Rowitch, D. H.; Salum, G. A.; Satterthwaite, T. D.; Schaare, H. L.; Schachar, R. J.; Schultz, A. P.; Schumann, G.; Schöll, M.; Sharp, D.; Shinohara, R. T.; Skoog, I.; Smyser, C. D.; Sperling, R. A.; Stein, D. J.; Stolicyn, A.; Suckling, J.; Sullivan, G.; Taki, Y.; Thyreau, B.; Toro, R.; Traut, N.; Tsvetanov, K. A.; Turk-Browne, N. B.; Tuulari, J. J.; Tzourio, C.; Vachon-Presseau, É.; Valdes-Sosa, M. J.; Valdes-Sosa, P. A.; Valk, S. L.; Amelsvoort, T.; Vandekar, S. N.; Vasung, L.; Victoria, L. W.; Villeneuve, S.; Villringer, A.; Vértes, P. E.; Wagstyl, K.; Wang, Y. S.; Warfield, S. K.; Warrier, V.; Westman, E.; Westwater, M. L.; Whalley, H. C.; Witte, A. V.; Yang, N.; Yeo, B.; Yun, H.; Zalesky, A.; Zar, H. J.; Zettergren, A.; Zhou, J. H.; Ziauddeen, H.; Zugman, A.; Zuo, X. N.; Bullmore, E. T.; Alexander-Bloch, A. F.

Brain charts for the human lifespan

R. A. I. Bethlehem (), J. Seidlitz (), S. R. White, J. W. Vogel, K. M. Anderson, C. Adamson, S. Adler, G. S. Alexopoulos, E. Anagnostou, A. Areces-Gonzalez, D. E. Astle, B. Auyeung, M. Ayub, J. Bae, G. Ball, S. Baron-Cohen, R. Beare, S. A. Bedford, V. Benegal, F. Beyer, J. Blangero, M. Blesa Cábez, J. P. Boardman, M. Borzage, J. F. Bosch-Bayard, N. Bourke, V. D. Calhoun, M. M. Chakravarty, C. Chen, C. Chertavian, G. Chetelat, Y. S. Chong, J. H. Cole, A. Corvin, M. Costantino, E. Courchesne, F. Crivello, V. L. Cropley, J. Crosbie, N. Crossley, M. Delarue, R. Delorme, S. Desrivieres, G. A. Devenyi, M. A. Biase, R. Dolan, K. A. Donald, G. Donohoe, K. Dunlop, A. D. Edwards, J. T. Elison, C. T. Ellis, J. A. Elman, L. Eyler, D. A. Fair, E. Feczko, P. C. Fletcher, P. Fonagy, C. E. Franz, L. Galan-Garcia, A. Gholipour, J. Giedd, J. H. Gilmore, D. C. Glahn, I. M. Goodyer, P. E. Grant, N. A. Groenewold, F. M. Gunning, R. E. Gur, R. C. Gur, C. F. Hammill, O. Hansson, T. Hedden, A. Heinz, R. N. Henson, K. Heuer, J. Hoare, B. Holla, A. J. Holmes, R. Holt, H. Huang, K. Im, J. Ipser, C. R. Jack, A. P. Jackowski, T. Jia, K. A. Johnson, P. B. Jones, D. T. Jones, R. S. Kahn, H. Karlsson, L. Karlsson, R. Kawashima, E. A. Kelley, S. Kern, K. W. Kim, M. G. Kitzbichler, W. S. Kremen, F. Lalonde, B. Landeau, S. Lee, J. Lerch, J. D. Lewis, J. Li, W. Liao, C. Liston, M. V. Lombardo, J. Lv, C. Lynch, T. T. Mallard, M. Marcelis, R. D. Markello, S. R. Mathias, B. Mazoyer, P. McGuire, M. J. Meaney, A. Mechelli, N. Medic, B. Misic, S. E. Morgan, D. Mothersill, J. Nigg, M. Q. W. Ong, C. Ortinau, R. Ossenkoppele, M. Ouyang, L. Palaniyappan, L. Paly, P. M. Pan, C. Pantelis, M. M. Park, T. Paus, Z. Pausova, D. Paz-Linares, A. Pichet Binette, K. Pierce, X. Qian, J. Qiu, A. Qiu, A. Raznahan, T. Rittman, A. Rodrigue, C. K. Rollins, R. Romero-Garcia, L. Ronan, M. D. Rosenberg, D. H. Rowitch, G. A. Salum, T. D. Satterthwaite, H. L. Schaare, R. J. Schachar, A. P. Schultz, G. Schumann, M. Schöll, D. Sharp, R. T. Shinohara, I. Skoog, C. D. Smyser, R. A. Sperling, D. J. Stein, A. Stolicyn, J. Suckling, G. Sullivan, Y. Taki, B. Thyreau, R. Toro, N. Traut, K. A. Tsvetanov, N. B. Turk-Browne, J. J. Tuulari, C. Tzourio, É. Vachon-Presseau, M. J. Valdes-Sosa, P. A. Valdes-Sosa, S. L. Valk, T. Amelsvoort, S. N. Vandekar, L. Vasung, L. W. Victoria, S. Villeneuve, A. Villringer, P. E. Vértes, K. Wagstyl, Y. S. Wang, S. K. Warfield, V. Warrier, E. Westman, M. L. Westwater, H. C. Whalley, A. V. Witte, N. Yang, B. Yeo, H. Yun, A. Zalesky, H. J. Zar, A. Zettergren, J. H. Zhou, H. Ziauddeen, A. Zugman, X. N. Zuo, E. T. Bullmore and A. F. Alexander-Bloch
Additional contact information
R. A. I. Bethlehem: University of Cambridge
J. Seidlitz: University of Pennsylvania
S. R. White: University of Cambridge
J. W. Vogel: University of Pennsylvania
K. M. Anderson: Yale University
C. Adamson: Murdoch Children’s Research Institute
S. Adler: UCL Great Ormond Street Institute for Child Health
G. S. Alexopoulos: Weill Cornell Medicine
E. Anagnostou: Department of Pediatrics University of Toronto
A. Areces-Gonzalez: University of Electronic Science and Technology of China
D. E. Astle: University of Cambridge
B. Auyeung: University of Cambridge
M. Ayub: Queen’s University, Department of Psychiatry, Centre for Neuroscience Studies
J. Bae: Seoul National University Bundang Hospital
G. Ball: Murdoch Children’s Research Institute
S. Baron-Cohen: University of Cambridge
R. Beare: Murdoch Children’s Research Institute
S. A. Bedford: University of Cambridge
V. Benegal: National Institute of Mental Health and Neurosciences (NIMHANS)
F. Beyer: Max Planck Institute for Human Cognitive and Brain Sciences
J. Blangero: University of Texas Rio Grande Valley
M. Blesa Cábez: University of Edinburgh
J. P. Boardman: University of Edinburgh
M. Borzage: Fetal and Neonatal Institute, Division of Neonatology, Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California
J. F. Bosch-Bayard: Montreal Neurological Institute
N. Bourke: Imperial College London
V. D. Calhoun: Georgia State University, Georgia Institute of Technology, and Emory University
M. M. Chakravarty: McGill University
C. Chen: University of Pennsylvania
C. Chertavian: The Children’s Hospital of Philadelphia and Penn Medicine
G. Chetelat: Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen-Normandie, Cyceron
Y. S. Chong: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research
J. H. Cole: University College London
A. Corvin: Trinity College
M. Costantino: Douglas Mental Health University Institute
E. Courchesne: University of California, San Diego
F. Crivello: Institute of Neurodegenerative Disorders, CNRS UMR5293, CEA, University of Bordeaux
V. L. Cropley: University of Melbourne
J. Crosbie: The Hospital for Sick Children
N. Crossley: Pontificia Universidad Católica de Chile
M. Delarue: Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen-Normandie, Cyceron
R. Delorme: Robert Debré University Hospital, AP-HP
S. Desrivieres: King’s College London
G. A. Devenyi: McGill Department of Psychiatry, Douglas Mental Health University Institute
M. A. Biase: University of Melbourne
R. Dolan: University College London
K. A. Donald: Red Cross War Memorial Children’s Hospital
G. Donohoe: National University of Ireland Galway
K. Dunlop: Weill Cornell Medicine
A. D. Edwards: King’s College London
J. T. Elison: University of Minnesota
C. T. Ellis: Yale University
J. A. Elman: University of California, San Diego
L. Eyler: VA San Diego Healthcare
D. A. Fair: University of Minnesota
E. Feczko: University of Minnesota
P. C. Fletcher: University of Cambridge, and Wellcome Trust MRC Institute of Metabolic Science, Cambridge Biomedical Campus
P. Fonagy: University College London
C. E. Franz: University of California, San Diego
L. Galan-Garcia: Cuban Center for Neuroscience
A. Gholipour: Boston Children’s Hospital
J. Giedd: University of California, San Diego
J. H. Gilmore: University of North Carolina
D. C. Glahn: Boston Children’s Hospital and Harvard Medical School
I. M. Goodyer: University of Cambridge
P. E. Grant: Boston Children’s Hospital, Harvard Medical School
N. A. Groenewold: University of Cape Town
F. M. Gunning: Weill Cornell Medicine
R. E. Gur: University of Pennsylvania
R. C. Gur: University of Pennsylvania
C. F. Hammill: The Hospital for Sick Children
O. Hansson: Lund University
T. Hedden: Icahn School of Medicine at Mount Sinai
A. Heinz: Department of Psychiatry and Psychotherapy, Charité Campus Mitte
R. N. Henson: University of Cambridge
K. Heuer: Max Planck Institute for Human Cognitive and Brain Sciences
J. Hoare: University of Cape Town
B. Holla: NIMHANS
A. J. Holmes: Yale University
R. Holt: University of Cambridge
H. Huang: Children’s Hospital of Philadelphia
K. Im: Boston Children’s Hospital and Harvard Medical School
J. Ipser: Clinical Neuroscience Institute, University of Cape Town
C. R. Jack: Mayo Clinic
A. P. Jackowski: Universidade Federal de São Paulo
T. Jia: Fudan University
K. A. Johnson: Harvard Medical School
P. B. Jones: University of Cambridge
D. T. Jones: Mayo Clinic
R. S. Kahn: Icahn School of Medicine
H. Karlsson: University of Turku and Turku University Hospital
L. Karlsson: University of Turku and Turku University Hospital
R. Kawashima: Tohoku University, Seiryocho, Aobaku
E. A. Kelley: Queen’s University, Departments of Psychology and Psychiatry, Centre for Neuroscience Studies
S. Kern: Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg
K. W. Kim: Seoul National University College of Natural Sciences
M. G. Kitzbichler: University of Cambridge
W. S. Kremen: University of California, San Diego
F. Lalonde: National Institute of Mental Health
B. Landeau: Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen-Normandie, Cyceron
S. Lee: Seoul National University College of Natural Sciences
J. Lerch: Mouse Imaging Centre
J. D. Lewis: McGill University
J. Li: University of Electronic Science and Technology of China
W. Liao: University of Electronic Science and Technology of China
C. Liston: Weill Cornell Medicine
M. V. Lombardo: University of Cambridge
J. Lv: University of Melbourne
C. Lynch: Weill Cornell Medicine
T. T. Mallard: University of Texas
M. Marcelis: Maastricht University Medical Centre
R. D. Markello: McGill University
S. R. Mathias: Boston Children’s Hospital and Harvard Medical School
B. Mazoyer: Institute of Neurodegenerative Disorders, CNRS UMR5293, CEA, University of Bordeaux
P. McGuire: King’s College London
M. J. Meaney: Douglas Mental Health University Institute
A. Mechelli: Bordeaux University Hospital
N. Medic: University of Cambridge
B. Misic: McGill University
S. E. Morgan: University of Cambridge
D. Mothersill: National College of Ireland
J. Nigg: Oregon Health and Science University
M. Q. W. Ong: National University of Singapore
C. Ortinau: Washington University in St Louis
R. Ossenkoppele: Vrije Universiteit Amsterdam, Amsterdam UMC
M. Ouyang: Children’s Hospital of Philadelphia
L. Palaniyappan: University of Western Ontario
L. Paly: Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen-Normandie, Cyceron
P. M. Pan: Federal University of Sao Poalo (UNIFESP)
C. Pantelis: The University of Melbourne and Melbourne Health
M. M. Park: Western University
T. Paus: Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal
Z. Pausova: The Hospital for Sick Children
D. Paz-Linares: University of Electronic Science and Technology of China
A. Pichet Binette: McGill University
K. Pierce: University of California, San Diego
X. Qian: National University of Singapore
J. Qiu: Southwest University
A. Qiu: The N.1 Institute for Health, National University of Singapore
A. Raznahan: National Institute of Mental Health
T. Rittman: University of Cambridge
A. Rodrigue: Boston Children’s Hospital and Harvard Medical School
C. K. Rollins: Harvard Medical School
R. Romero-Garcia: University of Cambridge
L. Ronan: University of Cambridge
M. D. Rosenberg: University of Chicago
D. H. Rowitch: University of Cambridge
G. A. Salum: Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clinicas de Porto Alegre
T. D. Satterthwaite: University of Pennsylvania
H. L. Schaare: Max Planck Institute for Human Cognitive and Brain Sciences
R. J. Schachar: The Hospital for Sick Children
A. P. Schultz: Harvard Medical School
G. Schumann: Institute for Science and Technology for Brain-inspired Intelligence, Fudan University
M. Schöll: University of Gothenburg
D. Sharp: Imperial College London
R. T. Shinohara: University of Pennsylvania
I. Skoog: Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg
C. D. Smyser: Washington University School of Medicine
R. A. Sperling: Harvard Medical School
D. J. Stein: University of Cape Town
A. Stolicyn: University of Edinburgh
J. Suckling: University of Cambridge
G. Sullivan: University of Edinburgh
Y. Taki: Tohoku University, Seiryocho, Aobaku
B. Thyreau: Tohoku University, Seiryocho, Aobaku
R. Toro: Université de Paris
N. Traut: Institut Pasteur
K. A. Tsvetanov: University of Cambridge
N. B. Turk-Browne: Yale University
J. J. Tuulari: University of Turku and Turku University Hospital
C. Tzourio: Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, U1219, CHU Bordeaux
É. Vachon-Presseau: McGill University
M. J. Valdes-Sosa: Cuban Center for Neuroscience
P. A. Valdes-Sosa: University of Electronic Science and Technology of China
S. L. Valk: Institute for Neuroscience and Medicine 7, Forschungszentrum Jülich
T. Amelsvoort: Maastricht University
S. N. Vandekar: Vanderbilt University
L. Vasung: McGill University
L. W. Victoria: Weill Cornell Medicine
S. Villeneuve: McGill University
A. Villringer: Max Planck Institute for Human Cognitive and Brain Sciences
P. E. Vértes: University of Cambridge
K. Wagstyl: Wellcome Centre for Human Neuroimaging
Y. S. Wang: Beijing Normal University
S. K. Warfield: Boston Children’s Hospital
V. Warrier: University of Cambridge
E. Westman: Karolinska Institutet
M. L. Westwater: University of Cambridge
H. C. Whalley: University of Edinburgh
A. V. Witte: Max Planck Institute for Human Cognitive and Brain Sciences
N. Yang: Beijing Normal University
B. Yeo: National University of Singapore
H. Yun: Boston Children’s Hospital, Harvard Medical School
A. Zalesky: University of Melbourne
H. J. Zar: Red Cross War Memorial Children’s Hospital, SA-MRC Unit on Child & Adolescent Health, University of Cape Town
A. Zettergren: Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg
J. H. Zhou: National University of Singapore
H. Ziauddeen: University of Cambridge
A. Zugman: National Institute of Developmental Psychiatry for Children and Adolescents (INPD)
X. N. Zuo: Beijing Normal University
E. T. Bullmore: University of Cambridge
A. F. Alexander-Bloch: University of Pennsylvania

Nature, 2022, vol. 604, issue 7906, 525-533

Abstract: Abstract Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.

Date: 2022
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41586-022-04554-y Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:604:y:2022:i:7906:d:10.1038_s41586-022-04554-y

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-022-04554-y

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().