Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Lei Han, Xiaoyu Wei, Chuanyu Liu, Giacomo Volpe, Zhenkun Zhuang, Xuanxuan Zou, Zhifeng Wang, Taotao Pan, Yue Yuan, Xiao Zhang, Peng Fan, Pengcheng Guo, Yiwei Lai, Ying Lei, Xingyuan Liu, Feng Yu, Shuncheng Shangguan, Guangyao Lai, Qiuting Deng, Ya Liu, Liang Wu, Quan Shi, Hao Yu, Yunting Huang, Mengnan Cheng, Jiangshan Xu, Yang Liu, Mingyue Wang, Chunqing Wang, Yuanhang Zhang, Duo Xie, Yunzhi Yang, Yeya Yu, Huiwen Zheng, Yanrong Wei, Fubaoqian Huang, Junjie Lei, Waidong Huang, Zhiyong Zhu, Haorong Lu, Bo Wang, Xiaofeng Wei, Fengzhen Chen, Tao Yang, Wensi Du, Jing Chen, Shibo Xu, Juan An, Carl Ward, Zongren Wang, Zhong Pei, Chi-Wai Wong, Xiaolei Liu, Huafeng Zhang, Mingyuan Liu, Baoming Qin, Axel Schambach, Joan Isern, Liqiang Feng, Yan Liu, Xiangyu Guo, Zhen Liu, Qiang Sun, Patrick H. Maxwell, Nick Barker, Pura Muñoz-Cánoves, Ying Gu, Jan Mulder, Mathias Uhlen, Tao Tan, Shiping Liu, Huanming Yang, Jian Wang, Yong Hou (), Xun Xu (), Miguel A. Esteban () and Longqi Liu ()
Additional contact information
Lei Han: BGI-Shenzhen
Xiaoyu Wei: BGI-Shenzhen
Chuanyu Liu: BGI-Shenzhen
Giacomo Volpe: IRCCS–Istituto Tumori ‘Giovanni Paolo II’
Zhenkun Zhuang: BGI-Shenzhen
Xuanxuan Zou: BGI-Shenzhen
Zhifeng Wang: BGI-Shenzhen
Taotao Pan: BGI-Shenzhen
Yue Yuan: BGI-Shenzhen
Xiao Zhang: Jilin University
Peng Fan: Jilin University
Pengcheng Guo: Jilin University
Yiwei Lai: Chinese Academy of Sciences
Ying Lei: BGI-Shenzhen
Xingyuan Liu: Jilin University
Feng Yu: Chinese Academy of Sciences
Shuncheng Shangguan: Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University
Guangyao Lai: Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University
Qiuting Deng: BGI-Shenzhen
Ya Liu: BGI-Shenzhen
Liang Wu: BGI-Shenzhen
Quan Shi: BGI-Shenzhen
Hao Yu: BGI-Shenzhen
Yunting Huang: BGI-Shenzhen
Mengnan Cheng: BGI-Shenzhen
Jiangshan Xu: BGI-Shenzhen
Yang Liu: BGI-Shenzhen
Mingyue Wang: BGI-Shenzhen
Chunqing Wang: BGI-Shenzhen
Yuanhang Zhang: BGI-Shenzhen
Duo Xie: BGI-Shenzhen
Yunzhi Yang: Zhengzhou University
Yeya Yu: Zhengzhou University
Huiwen Zheng: Zhengzhou University
Yanrong Wei: Zhengzhou University
Fubaoqian Huang: BGI-Shenzhen
Junjie Lei: BGI-Shenzhen
Waidong Huang: BGI-Shenzhen
Zhiyong Zhu: BGI-Shenzhen
Haorong Lu: BGI-Shenzhen
Bo Wang: BGI-Shenzhen
Xiaofeng Wei: BGI-Shenzhen
Fengzhen Chen: BGI-Shenzhen
Tao Yang: BGI-Shenzhen
Wensi Du: BGI-Shenzhen
Jing Chen: BGI-Shenzhen
Shibo Xu: Nanjing Medical University
Juan An: Chinese Academy of Sciences
Carl Ward: Chinese Academy of Sciences
Zongren Wang: Sun Yat-sen University
Zhong Pei: Sun Yat-sen University
Chi-Wai Wong: Huazhen Biosciences
Xiaolei Liu: Jilin University
Huafeng Zhang: Tianjin Medical University General Hospital
Mingyuan Liu: Jilin University
Baoming Qin: Chinese Academy of Sciences
Axel Schambach: Hannover Medical School
Joan Isern: Spanish National Center for Cardiovascular Research (CNIC)
Liqiang Feng: Chinese Academy of Sciences
Yan Liu: Nanjing Medical University
Xiangyu Guo: Jinan University
Zhen Liu: Chinese Academy of Sciences
Qiang Sun: Chinese Academy of Sciences
Patrick H. Maxwell: University of Cambridge
Nick Barker: A*STAR Institute of Molecular and Cell Biology
Pura Muñoz-Cánoves: Pompeu Fabra University (UPF), ICREA and CIBERNED
Ying Gu: BGI-Shenzhen
Jan Mulder: KTH–Royal Institute of Technology
Mathias Uhlen: KTH–Royal Institute of Technology
Tao Tan: Kunming University of Science and Technology
Shiping Liu: BGI-Shenzhen
Huanming Yang: BGI-Shenzhen
Jian Wang: BGI-Shenzhen
Yong Hou: BGI-Shenzhen
Xun Xu: BGI-Shenzhen
Miguel A. Esteban: Jilin University
Longqi Liu: BGI-Shenzhen

Nature, 2022, vol. 604, issue 7907, 723-731

Abstract: Abstract Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.

Date: 2022
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DOI: 10.1038/s41586-022-04587-3

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