Maternal enzyme reprograms paternal DNA for healthy offspring

Yumiko K. Kawamura () and Antoine H. F. M. Peters ()

Nature, 2022, vol. 605, issue 7911, 621-622

Abstract: It emerges that high blood sugar deregulates the enzyme TET3 in the eggs of female mice, preventing it from properly modifying sperm-derived DNA when eggs are fertilized. This leads to metabolic defects in adult progeny.

Keywords: Epigenetics; Physiology; Diabetes (search for similar items in EconPapers)
Date: 2022
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DOI: 10.1038/d41586-022-01237-6

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