Intracellular lipid surveillance by small G protein geranylgeranylation

Abigail Watterson, Lexus Tatge, Naureen Wajahat, Sonja L. B. Arneaud, Rene Solano Fonseca, Shaghayegh T. Beheshti, Patrick Metang, Melina Mihelakis, Kielen R. Zuurbier, Chase D. Corley, Ishmael Dehghan, Jeffrey G. McDonald and Peter M. Douglas ()
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Abigail Watterson: University of Texas Southwestern Medical Center
Lexus Tatge: University of Texas Southwestern Medical Center
Naureen Wajahat: University of Texas Southwestern Medical Center
Sonja L. B. Arneaud: University of Texas Southwestern Medical Center
Rene Solano Fonseca: University of Texas Southwestern Medical Center
Shaghayegh T. Beheshti: University of Texas Southwestern Medical Center
Patrick Metang: University of Texas Southwestern Medical Center
Melina Mihelakis: University of Texas Southwestern Medical Center
Kielen R. Zuurbier: University of Texas Southwestern Medical Center
Chase D. Corley: University of Texas Southwestern Medical Center
Ishmael Dehghan: University of Texas Southwestern Medical Center
Jeffrey G. McDonald: University of Texas Southwestern Medical Center
Peter M. Douglas: University of Texas Southwestern Medical Center

Nature, 2022, vol. 605, issue 7911, 736-740

Abstract: Abstract Imbalances in lipid homeostasis can have deleterious effects on health1,2. Yet how cells sense metabolic demand due to lipid depletion and respond by increasing nutrient absorption remains unclear. Here we describe a mechanism for intracellular lipid surveillance in Caenorhabditis elegans that involves transcriptional inactivation of the nuclear hormone receptor NHR-49 through its cytosolic sequestration to endocytic vesicles via geranylgeranyl conjugation to the small G protein RAB-11.1. Defective de novo isoprenoid synthesis caused by lipid depletion limits RAB-11.1 geranylgeranylation, which promotes nuclear translocation of NHR-49 and activation of rab-11.2 transcription to enhance transporter residency at the plasma membrane. Thus, we identify a critical lipid sensed by the cell, its conjugated G protein, and the nuclear receptor whose dynamic interactions enable cells to sense metabolic demand due to lipid depletion and respond by increasing nutrient absorption and lipid metabolism.

Date: 2022
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DOI: 10.1038/s41586-022-04729-7

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