Genomics to select treatment for patients with metastatic breast cancer

Fabrice Andre (), Thomas Filleron, Maud Kamal, Fernanda Mosele, Monica Arnedos, Florence Dalenc, Marie-Paule Sablin, Mario Campone, Hervé Bonnefoi, Claudia Lefeuvre-Plesse, William Jacot, Florence Coussy, Jean-Marc Ferrero, George Emile, Marie-Ange Mouret-Reynier, Jean-Christophe Thery, Nicolas Isambert, Alice Mege, Philippe Barthelemy, Benoit You, Nawale Hajjaji, Ludovic Lacroix, Etienne Rouleau, Alicia Tran-Dien, Sandrine Boyault, Valery Attignon, Pierre Gestraud, Nicolas Servant, Christophe Tourneau, Linda Larbi Cherif, Isabelle Soubeyran, Filippo Montemurro, Alain Morel, Amelie Lusque, Marta Jimenez, Alexandra Jacquet, Anthony Gonçalves, Thomas Bachelot and Ivan Bieche
Additional contact information
Fabrice Andre: Gustave Roussy
Thomas Filleron: Institut Claudius Regaud, IUCT oncopole
Maud Kamal: Institut Curie
Fernanda Mosele: INSERM U981, Gustave Roussy
Monica Arnedos: Gustave Roussy
Florence Dalenc: Institut Claudius-Regaud IUCT oncopole and University of Paul Sabatier
Marie-Paule Sablin: Institut Curie
Mario Campone: Institut de Cancérologie de l’Ouest – René Gauducheau, Saint Herblain, University of Angers
Hervé Bonnefoi: Institut Bergonié INSERM U1218 and Université of Bordeaux
Claudia Lefeuvre-Plesse: Centre Eugène Marquis
William Jacot: Institut du Cancer de Montpellier, Institut de Recherche en Cancérologie de Montpellier INSERM U1194 and Montpellier University
Florence Coussy: Institut Curie
Jean-Marc Ferrero: Centre Antoine Lacassagne, University Côte d’Azur
George Emile: Centre François Baclesse
Marie-Ange Mouret-Reynier: Centre Jean Perrin
Jean-Christophe Thery: Centre Hennri Becquerel, University of Medicine of Rouen
Nicolas Isambert: Centre Georges François Leclerc
Alice Mege: Institut Sainte Catherine
Philippe Barthelemy: Institut de Cancérologie Strasbourg Europe
Benoit You: Institut de Cancérologie des Hospices Civils de Lyon, Université Claude Bernard Lyon 1
Nawale Hajjaji: Centre Oscar Lambret INSERM U1192 PRISM Laboratory and University of Lille
Ludovic Lacroix: Gustave Roussy
Etienne Rouleau: Gustave Roussy
Alicia Tran-Dien: INSERM U981, Gustave Roussy
Sandrine Boyault: Centre Léon Bérard
Valery Attignon: Centre Léon Bérard
Pierre Gestraud: PSL Research University, Mines Paris Tech, INSERM U900
Nicolas Servant: PSL Research University, Mines Paris Tech, INSERM U900
Christophe Tourneau: Institut Curie
Linda Larbi Cherif: Institut Curie
Isabelle Soubeyran: Institut Bergonié
Filippo Montemurro: FPO-IRCCS
Alain Morel: Institut de Cancérologie de l’Ouest – Centre Paul Papin
Amelie Lusque: Institut Claudius Regaud, IUCT oncopole
Marta Jimenez: Unicancer
Alexandra Jacquet: Unicancer
Anthony Gonçalves: Institut Paoli-Calmettes
Thomas Bachelot: Centre Léon Bérard
Ivan Bieche: Institut Curie, INSERM U1016, Université Paris Cité

Nature, 2022, vol. 610, issue 7931, 343-348

Abstract: Abstract Cancer progression is driven in part by genomic alterations1. The genomic characterization of cancers has shown interpatient heterogeneity regarding driver alterations2, leading to the concept that generation of genomic profiling in patients with cancer could allow the selection of effective therapies3,4. Although DNA sequencing has been implemented in practice, it remains unclear how to use its results. A total of 1,462 patients with HER2-non-overexpressing metastatic breast cancer were enroled to receive genomic profiling in the SAFIR02-BREAST trial. Two hundred and thirty-eight of these patients were randomized in two trials (nos. NCT02299999 and NCT03386162) comparing the efficacy of maintenance treatment5 with a targeted therapy matched to genomic alteration. Targeted therapies matched to genomics improves progression-free survival when genomic alterations are classified as level I/II according to the ESMO Scale for Clinical Actionability of Molecular Targets (ESCAT)6 (adjusted hazards ratio (HR): 0.41, 90% confidence interval (CI): 0.27–0.61, P

Date: 2022
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DOI: 10.1038/s41586-022-05068-3

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