Adeno-associated virus type 2 in US children with acute severe hepatitis

Venice Servellita, Alicia Sotomayor Gonzalez, Daryl M. Lamson, Abiodun Foresythe, Hee Jae Huh, Adam L. Bazinet, Nicholas H. Bergman, Robert L. Bull, Karla Y. Garcia, Jennifer S. Goodrich, Sean P. Lovett, Kisha Parker, Diana Radune, April Hatada, Chao-Yang Pan, Kyle Rizzo, J. Bradford Bertumen, Christina Morales, Paul E. Oluniyi, Jenny Nguyen, Jessica Tan, Doug Stryke, Rayah Jaber, Matthew T. Leslie, Zin Lyons, Hayden D. Hedman, Umesh Parashar, Maureen Sullivan, Kelly Wroblewski, M. Steven Oberste, Jacqueline E. Tate, Julia M. Baker, David Sugerman, Caelin Potts, Xiaoyan Lu, Preeti Chhabra, L. Amanda Ingram, Henry Shiau, William Britt, Luz Helena Gutierrez Sanchez, Caroline Ciric, Christina A. Rostad, Jan Vinjé, Hannah L. Kirking, Debra A. Wadford, R. Taylor Raborn, Kirsten George and Charles Y. Chiu ()
Additional contact information
Venice Servellita: University of California, San Francisco
Alicia Sotomayor Gonzalez: University of California, San Francisco
Daryl M. Lamson: David Axelrod Institute
Abiodun Foresythe: University of California, San Francisco
Hee Jae Huh: University of California, San Francisco
Adam L. Bazinet: National Biodefense Analysis and Countermeasures Center (NBACC)
Nicholas H. Bergman: National Biodefense Analysis and Countermeasures Center (NBACC)
Robert L. Bull: Federal Bureau of Investigation Laboratory Division/Scientific Response and Analysis Unit
Karla Y. Garcia: National Biodefense Analysis and Countermeasures Center (NBACC)
Jennifer S. Goodrich: National Biodefense Analysis and Countermeasures Center (NBACC)
Sean P. Lovett: National Biodefense Analysis and Countermeasures Center (NBACC)
Kisha Parker: National Biodefense Analysis and Countermeasures Center (NBACC)
Diana Radune: National Biodefense Analysis and Countermeasures Center (NBACC)
April Hatada: California Department of Public Health
Chao-Yang Pan: California Department of Public Health
Kyle Rizzo: California Department of Public Health
J. Bradford Bertumen: California Department of Public Health
Christina Morales: California Department of Public Health
Paul E. Oluniyi: University of California, San Francisco
Jenny Nguyen: University of California, San Francisco
Jessica Tan: University of California, San Francisco
Doug Stryke: University of California, San Francisco
Rayah Jaber: Florida Department of Health
Matthew T. Leslie: Illinois Department of Public Health
Zin Lyons: North Carolina Department of Health and Human Services
Hayden D. Hedman: Centers for Disease Control and Prevention
Umesh Parashar: Centers for Disease Control and Prevention
Maureen Sullivan: Association for Public Health Laboratories
Kelly Wroblewski: Association for Public Health Laboratories
M. Steven Oberste: Centers for Disease Control and Prevention
Jacqueline E. Tate: Centers for Disease Control and Prevention
Julia M. Baker: Centers for Disease Control and Prevention
David Sugerman: Centers for Disease Control and Prevention
Caelin Potts: Centers for Disease Control and Prevention
Xiaoyan Lu: Centers for Disease Control and Prevention
Preeti Chhabra: Centers for Disease Control and Prevention
L. Amanda Ingram: Alabama Department of Public Health
Henry Shiau: University of Alabama at Birmingham
William Britt: University of Alabama at Birmingham
Luz Helena Gutierrez Sanchez: University of Alabama at Birmingham
Caroline Ciric: Emory University School of Medicine and Children’s Healthcare of Atlanta
Christina A. Rostad: Emory University School of Medicine and Children’s Healthcare of Atlanta
Jan Vinjé: Centers for Disease Control and Prevention
Hannah L. Kirking: Centers for Disease Control and Prevention
Debra A. Wadford: California Department of Public Health
R. Taylor Raborn: National Biodefense Analysis and Countermeasures Center (NBACC)
Kirsten George: David Axelrod Institute
Charles Y. Chiu: University of California, San Francisco

Nature, 2023, vol. 617, issue 7961, 574-580

Abstract: Abstract As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have been reported from 35 countries, including the USA1,2. Previous studies have found human adenoviruses (HAdVs) in the blood from patients in Europe and the USA3–7, although it is unclear whether this virus is causative. Here we used PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing to analyse samples from 16 HAdV-positive cases from 1 October 2021 to 22 May 2022, in parallel with 113 controls. In blood from 14 cases, adeno-associated virus type 2 (AAV2) sequences were detected in 93% (13 of 14), compared to 4 (3.5%) of 113 controls (P

Date: 2023
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DOI: 10.1038/s41586-023-05949-1

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