Evolutionary histories of breast cancer and related clones

Tomomi Nishimura, Nobuyuki Kakiuchi, Kenichi Yoshida, Takaki Sakurai, Tatsuki R. Kataoka, Eiji Kondoh, Yoshitsugu Chigusa, Masahiko Kawai, Morio Sawada, Takuya Inoue, Yasuhide Takeuchi, Hirona Maeda, Satoko Baba, Yusuke Shiozawa, Ryunosuke Saiki, Masahiro M. Nakagawa, Yasuhito Nannya, Yotaro Ochi, Tomonori Hirano, Tomoe Nakagawa, Yukiko Inagaki-Kawata, Kosuke Aoki, Masahiro Hirata, Kosaku Nanki, Mami Matano, Megumu Saito, Eiji Suzuki, Masahiro Takada, Masahiro Kawashima, Kosuke Kawaguchi, Kenichi Chiba, Yuichi Shiraishi, Junko Takita, Satoru Miyano, Masaki Mandai, Toshiro Sato, Kengo Takeuchi, Hironori Haga, Masakazu Toi and Seishi Ogawa ()
Additional contact information
Tomomi Nishimura: Kyoto University
Nobuyuki Kakiuchi: Kyoto University
Kenichi Yoshida: Kyoto University
Takaki Sakurai: Kyoto University Hospital
Tatsuki R. Kataoka: Kyoto University Hospital
Eiji Kondoh: Kyoto University
Yoshitsugu Chigusa: Kyoto University
Masahiko Kawai: Kyoto University
Morio Sawada: Adachi Hospital
Takuya Inoue: Adachi Hospital
Yasuhide Takeuchi: Kyoto University
Hirona Maeda: Kyoto University
Satoko Baba: Japanese Foundation for Cancer Research
Yusuke Shiozawa: Kyoto University
Ryunosuke Saiki: Kyoto University
Masahiro M. Nakagawa: Kyoto University
Yasuhito Nannya: Kyoto University
Yotaro Ochi: Kyoto University
Tomonori Hirano: Kyoto University
Tomoe Nakagawa: Kyoto University
Yukiko Inagaki-Kawata: Kyoto University
Kosuke Aoki: Kyoto University
Masahiro Hirata: Kyoto University Hospital
Kosaku Nanki: Keio University School of Medicine
Mami Matano: Keio University School of Medicine
Megumu Saito: Keio University School of Medicine
Eiji Suzuki: Kyoto University
Masahiro Takada: Kyoto University
Masahiro Kawashima: Kyoto University
Kosuke Kawaguchi: Kyoto University
Kenichi Chiba: National Cancer Center Research Institute
Yuichi Shiraishi: National Cancer Center Research Institute
Junko Takita: Kyoto University
Satoru Miyano: Tokyo Medical and Dental University
Masaki Mandai: Kyoto University
Toshiro Sato: Keio University School of Medicine
Kengo Takeuchi: Japanese Foundation for Cancer Research
Hironori Haga: Kyoto University Hospital
Masakazu Toi: Kyoto University
Seishi Ogawa: Kyoto University

Nature, 2023, vol. 620, issue 7974, 607-614

Abstract: Abstract Recent studies have documented frequent evolution of clones carrying common cancer mutations in apparently normal tissues, which are implicated in cancer development1–3. However, our knowledge is still missing with regard to what additional driver events take place in what order, before one or more of these clones in normal tissues ultimately evolve to cancer. Here, using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, we show unique evolutionary histories of breast cancers harbouring der(1;16), a common driver alteration found in roughly 20% of breast cancers. The approximate timing of early evolutionary events was estimated from the mutation rate measured in normal epithelial cells. In der(1;16)(+) cancers, the derivative chromosome was acquired from early puberty to late adolescence, followed by the emergence of a common ancestor by the patient’s early 30s, from which both cancer and non-cancer clones evolved. Replacing the pre-existing mammary epithelium in the following years, these clones occupied a large area within the premenopausal breast tissues by the time of cancer diagnosis. Evolution of multiple independent cancer founders from the non-cancer ancestors was common, contributing to intratumour heterogeneity. The number of driver events did not correlate with histology, suggesting the role of local microenvironments and/or epigenetic driver events. A similar evolutionary pattern was also observed in another case evolving from an AKT1-mutated founder. Taken together, our findings provide new insight into how breast cancer evolves.

Date: 2023
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41586-023-06333-9 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:620:y:2023:i:7974:d:10.1038_s41586-023-06333-9

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-023-06333-9

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().