Injectable tissue prosthesis for instantaneous closed-loop rehabilitation

Subin Jin, Heewon Choi, Duhwan Seong, Chang-Lim You, Jong-Sun Kang, Seunghyok Rho, Won Bo Lee, Donghee Son () and Mikyung Shin ()
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Subin Jin: Sungkyunkwan University
Heewon Choi: Center for Neuroscience Imaging Research, Institute for Basic Science
Duhwan Seong: Center for Neuroscience Imaging Research, Institute for Basic Science
Chang-Lim You: Sungkyunkwan University
Jong-Sun Kang: Sungkyunkwan University
Seunghyok Rho: Seoul National University
Won Bo Lee: Seoul National University
Donghee Son: Center for Neuroscience Imaging Research, Institute for Basic Science
Mikyung Shin: Sungkyunkwan University

Nature, 2023, vol. 623, issue 7985, 58-65

Abstract: Abstract To construct tissue-like prosthetic materials, soft electroactive hydrogels are the best candidate owing to their physiological mechanical modulus, low electrical resistance and bidirectional stimulating and recording capability of electrophysiological signals from biological tissues1,2. Nevertheless, until now, bioelectronic devices for such prostheses have been patch type, which cannot be applied onto rough, narrow or deep tissue surfaces3–5. Here we present an injectable tissue prosthesis with instantaneous bidirectional electrical conduction in the neuromuscular system. The soft and injectable prosthesis is composed of a biocompatible hydrogel with unique phenylborate-mediated multiple crosslinking, such as irreversible yet freely rearrangeable biphenyl bonds and reversible coordinate bonds with conductive gold nanoparticles formed in situ by cross-coupling. Closed-loop robot-assisted rehabilitation by injecting this prosthetic material is successfully demonstrated in the early stage of severe muscle injury in rats, and accelerated tissue repair is achieved in the later stage.

Date: 2023
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DOI: 10.1038/s41586-023-06628-x

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