Spatial IMA1 regulation restricts root iron acquisition on MAMP perception

Min Cao, Matthieu Pierre Platre, Huei-Hsuan Tsai, Ling Zhang, Tatsuya Nobori, Laia Armengot, Yintong Chen, Wenrong He, Lukas Brent, Nuria S. Coll, Joseph R. Ecker, Niko Geldner and Wolfgang Busch ()
Additional contact information
Min Cao: Salk Institute for Biological Studies
Matthieu Pierre Platre: Salk Institute for Biological Studies
Huei-Hsuan Tsai: University of Lausanne
Ling Zhang: Salk Institute for Biological Studies
Tatsuya Nobori: Salk Institute for Biological Studies
Laia Armengot: CSIC-IRTA-UAB-UB, Campus UAB
Yintong Chen: Salk Institute for Biological Studies
Wenrong He: Salk Institute for Biological Studies
Lukas Brent: Salk Institute for Biological Studies
Nuria S. Coll: CSIC-IRTA-UAB-UB, Campus UAB
Joseph R. Ecker: Salk Institute for Biological Studies
Niko Geldner: University of Lausanne
Wolfgang Busch: Salk Institute for Biological Studies

Nature, 2024, vol. 625, issue 7996, 750-759

Abstract: Abstract Iron is critical during host–microorganism interactions1–4. Restriction of available iron by the host during infection is an important defence strategy, described as nutritional immunity5. However, this poses a conundrum for externally facing, absorptive tissues such as the gut epithelium or the plant root epidermis that generate environments that favour iron bioavailability. For example, plant roots acquire iron mostly from the soil and, when iron deficient, increase iron availability through mechanisms that include rhizosphere acidification and secretion of iron chelators6–9. Yet, the elevated iron bioavailability would also be beneficial for the growth of bacteria that threaten plant health. Here we report that microorganism-associated molecular patterns such as flagellin lead to suppression of root iron acquisition through a localized degradation of the systemic iron-deficiency signalling peptide Iron Man 1 (IMA1) in Arabidopsis thaliana. This response is also elicited when bacteria enter root tissues, but not when they dwell on the outer root surface. IMA1 itself has a role in modulating immunity in root and shoot, affecting the levels of root colonization and the resistance to a bacterial foliar pathogen. Our findings reveal an adaptive molecular mechanism of nutritional immunity that affects iron bioavailability and uptake, as well as immune responses.

Date: 2024
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DOI: 10.1038/s41586-023-06891-y

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