Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Ken Suzuki, Konstantinos Hatzikotoulas (), Lorraine Southam, Henry J. Taylor, Xianyong Yin, Kim M. Lorenz, Ravi Mandla, Alicia Huerta-Chagoya, Giorgio E. M. Melloni, Stavroula Kanoni, Nigel W. Rayner, Ozvan Bocher, Ana Luiza Arruda, Kyuto Sonehara, Shinichi Namba, Simon S. K. Lee, Michael H. Preuss, Lauren E. Petty, Philip Schroeder, Brett Vanderwerff, Mart Kals, Fiona Bragg, Kuang Lin, Xiuqing Guo, Weihua Zhang, Jie Yao, Young Jin Kim, Mariaelisa Graff, Fumihiko Takeuchi, Jana Nano, Amel Lamri, Masahiro Nakatochi, Sanghoon Moon, Robert A. Scott, James P. Cook, Jung-Jin Lee, Ian Pan, Daniel Taliun, Esteban J. Parra, Jin-Fang Chai, Lawrence F. Bielak, Yasuharu Tabara, Yang Hai, Gudmar Thorleifsson, Niels Grarup, Tamar Sofer, Matthias Wuttke, Chloé Sarnowski, Christian Gieger, Darryl Nousome, Stella Trompet, Soo-Heon Kwak, Jirong Long, Meng Sun, Lin Tong, Wei-Min Chen, Suraj S. Nongmaithem, Raymond Noordam, Victor J. Y. Lim, Claudia H. T. Tam, Yoonjung Yoonie Joo, Chien-Hsiun Chen, Laura M. Raffield, Bram Peter Prins, Aude Nicolas, Lisa R. Yanek, Guanjie Chen, Jennifer A. Brody, Edmond Kabagambe, Ping An, Anny H. Xiang, Hyeok Sun Choi, Brian E. Cade, Jingyi Tan, K. Alaine Broadaway, Alice Williamson, Zoha Kamali, Jinrui Cui, Manonanthini Thangam, Linda S. Adair, Adebowale Adeyemo, Carlos A. Aguilar-Salinas, Tarunveer S. Ahluwalia, Sonia S. Anand, Alain Bertoni, Jette Bork-Jensen, Ivan Brandslund, Thomas A. Buchanan, Charles F. Burant, Adam S. Butterworth, Mickaël Canouil, Juliana C. N. Chan, Li-Ching Chang, Miao-Li Chee, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengming Chen, Lee-Ming Chuang, Mary Cushman, John Danesh, Swapan K. Das, H. Janaka Silva, George Dedoussis, Latchezar Dimitrov, Ayo P. Doumatey, Shufa Du, Qing Duan, Kai-Uwe Eckardt, Leslie S. Emery, Daniel S. Evans, Michele K. Evans, Krista Fischer, James S. Floyd, Ian Ford, Oscar H. Franco, Timothy M. Frayling, Barry I. Freedman, Pauline Genter, Hertzel C. Gerstein, Vilmantas Giedraitis, Clicerio González-Villalpando, Maria Elena González-Villalpando, Penny Gordon-Larsen, Myron Gross, Lindsay A. Guare, Sophie Hackinger, Liisa Hakaste, Sohee Han, Andrew T. Hattersley, Christian Herder, Momoko Horikoshi, Annie-Green Howard, Willa Hsueh, Mengna Huang, Wei Huang, Yi-Jen Hung, Mi Yeong Hwang, Chii-Min Hwu, Sahoko Ichihara, Mohammad Arfan Ikram, Martin Ingelsson, Md. Tariqul Islam, Masato Isono, Hye-Mi Jang, Farzana Jasmine, Guozhi Jiang, Jost B. Jonas, Torben Jørgensen, Frederick K. Kamanu, Fouad R. Kandeel, Anuradhani Kasturiratne, Tomohiro Katsuya, Varinderpal Kaur, Takahisa Kawaguchi, Jacob M. Keaton, Abel N. Kho, Chiea-Chuen Khor, Muhammad G. Kibriya, Duk-Hwan Kim, Florian Kronenberg, Johanna Kuusisto, Kristi Läll, Leslie A. Lange, Kyung Min Lee, Myung-Shik Lee, Nanette R. Lee, Aaron Leong, Liming Li, Yun Li, Ruifang Li-Gao, Symen Ligthart, Cecilia M. Lindgren, Allan Linneberg, Ching-Ti Liu, Jianjun Liu, Adam E. Locke, Tin Louie, Jian’an Luan, Andrea O. Luk, Xi Luo, Jun Lv, Julie A. Lynch, Valeriya Lyssenko, Shiro Maeda, Vasiliki Mamakou, Sohail Rafik Mansuri, Koichi Matsuda, Thomas Meitinger, Olle Melander, Andres Metspalu, Huan Mo, Andrew D. Morris, Filipe A. Moura, Jerry L. Nadler, Michael A. Nalls, Uma Nayak, Ioanna Ntalla, Yukinori Okada, Lorena Orozco, Sanjay R. Patel, Snehal Patil, Pei Pei, Mark A. Pereira, Annette Peters, Fraser J. Pirie, Hannah G. Polikowsky, Bianca Porneala, Gauri Prasad, Laura J. Rasmussen-Torvik, Alexander P. Reiner, Michael Roden, Rebecca Rohde, Katheryn Roll, Charumathi Sabanayagam, Kevin Sandow, Alagu Sankareswaran, Naveed Sattar, Sebastian Schönherr, Mohammad Shahriar, Botong Shen, Jinxiu Shi, Dong Mun Shin, Nobuhiro Shojima, Jennifer A. Smith, Wing Yee So, Alena Stančáková, Valgerdur Steinthorsdottir, Adrienne M. Stilp, Konstantin Strauch, Kent D. Taylor, Barbara Thorand, Unnur Thorsteinsdottir, Brian Tomlinson, Tam C. Tran, Fuu-Jen Tsai, Jaakko Tuomilehto, Teresa Tusie-Luna, Miriam S. Udler, Adan Valladares-Salgado, Rob M. Dam, Jan B. Klinken, Rohit Varma, Niels Wacher-Rodarte, Eleanor Wheeler, Ananda R. Wickremasinghe, Ko Willems Dijk, Daniel R. Witte, Chittaranjan S. Yajnik, Ken Yamamoto, Kenichi Yamamoto, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Salim Yusuf, Matthew Zawistowski, Liang Zhang, Wei Zheng, Leslie J. Raffel, Michiya Igase, Eli Ipp, Susan Redline, Yoon Shin Cho, Lars Lind, Michael A. Province, Myriam Fornage, Craig L. Hanis, Erik Ingelsson, Alan B. Zonderman, Bruce M. Psaty, Ya-Xing Wang, Charles N. Rotimi, Diane M. Becker, Fumihiko Matsuda, Yongmei Liu, Mitsuhiro Yokota, Sharon L. R. Kardia, Patricia A. Peyser, James S. Pankow, James C. Engert, Amélie Bonnefond, Philippe Froguel, James G. Wilson, Wayne H. H. Sheu, Jer-Yuarn Wu, M. Geoffrey Hayes, Ronald C. W. Ma, Tien-Yin Wong, Dennis O. Mook-Kanamori, Tiinamaija Tuomi, Giriraj R. Chandak, Francis S. Collins, Dwaipayan Bharadwaj, Guillaume Paré, Michèle M. Sale, Habibul Ahsan, Ayesha A. Motala, Xiao-Ou Shu, Kyong-Soo Park, J. Wouter Jukema, Miguel Cruz, Yii- Der Ida Chen, Stephen S. Rich, Roberta McKean-Cowdin, Harald Grallert, Ching-Yu Cheng, Mohsen Ghanbari, E-Shyong Tai, Josee Dupuis, Norihiro Kato, Markku Laakso, Anna Köttgen, Woon-Puay Koh, Donald W. Bowden, Colin N. A. Palmer, Jaspal S. Kooner, Charles Kooperberg, Simin Liu, Kari E. North, Danish Saleheen, Torben Hansen, Oluf Pedersen, Nicholas J. Wareham, Juyoung Lee, Bong-Jo Kim, Iona Y. Millwood, Robin G. Walters, Kari Stefansson, Emma Ahlqvist, Mark O. Goodarzi, Karen L. Mohlke, Claudia Langenberg, Christopher A. Haiman, Ruth J. F. Loos, Jose C. Florez, Daniel J. Rader, Marylyn D. Ritchie, Sebastian Zöllner, Reedik Mägi, Nicholas A. Marston, Christian T. Ruff, David A. Heel, Sarah Finer, Joshua C. Denny, Toshimasa Yamauchi, Takashi Kadowaki, John C. Chambers, Maggie C. Y. Ng, Xueling Sim, Jennifer E. Below, Philip S. Tsao, Kyong-Mi Chang, Mark I. McCarthy, James B. Meigs, Anubha Mahajan, Cassandra N. Spracklen, Josep M. Mercader, Michael Boehnke, Jerome I. Rotter, Marijana Vujkovic, Benjamin F. Voight (), Andrew P. Morris () and Eleftheria Zeggini ()
Additional contact information
Ken Suzuki: University of Manchester
Konstantinos Hatzikotoulas: German Research Center for Environmental Health
Lorraine Southam: German Research Center for Environmental Health
Henry J. Taylor: National Institutes of Health
Xianyong Yin: Nanjing Medical University
Kim M. Lorenz: Corporal Michael J. Crescenz VA Medical Center
Ravi Mandla: Broad Institute of Harvard and MIT
Alicia Huerta-Chagoya: Broad Institute of Harvard and MIT
Giorgio E. M. Melloni: Harvard Medical School
Stavroula Kanoni: Queen Mary University of London
Nigel W. Rayner: German Research Center for Environmental Health
Ozvan Bocher: German Research Center for Environmental Health
Ana Luiza Arruda: German Research Center for Environmental Health
Kyuto Sonehara: Osaka University Graduate School of Medicine
Shinichi Namba: Osaka University Graduate School of Medicine
Simon S. K. Lee: Icahn School of Medicine at Mount Sinai
Michael H. Preuss: Icahn School of Medicine at Mount Sinai
Lauren E. Petty: Vanderbilt University Medical Center
Philip Schroeder: Broad Institute of Harvard and MIT
Brett Vanderwerff: University of Michigan
Mart Kals: University of Tartu
Fiona Bragg: University of Oxford
Kuang Lin: University of Oxford
Xiuqing Guo: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Weihua Zhang: Imperial College London
Jie Yao: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Young Jin Kim: National Institute of Health
Mariaelisa Graff: University of North Carolina at Chapel Hill
Fumihiko Takeuchi: National Center for Global Health and Medicine
Jana Nano: German Research Center for Environmental Health
Amel Lamri: McMaster University
Masahiro Nakatochi: Nagoya University Graduate School of Medicine
Sanghoon Moon: National Institute of Health
Robert A. Scott: University of Cambridge School of Clinical Medicine
James P. Cook: University of Liverpool
Jung-Jin Lee: University of Pennsylvania
Ian Pan: Brown University School of Public Health
Daniel Taliun: University of Michigan
Esteban J. Parra: University of Toronto at Mississauga
Jin-Fang Chai: National University of Singapore and National University Health System
Lawrence F. Bielak: University of Michigan
Yasuharu Tabara: Kyoto University Graduate School of Medicine
Yang Hai: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Gudmar Thorleifsson: Amgen
Niels Grarup: University of Copenhagen
Tamar Sofer: Harvard University
Matthias Wuttke: University of Freiburg
Chloé Sarnowski: University of Texas Health Science Center at Houston School of Public Health
Christian Gieger: German Research Center for Environmental Health
Darryl Nousome: Keck School of Medicine of USC
Stella Trompet: Leiden University Medical Center
Soo-Heon Kwak: Seoul National University Hospital
Jirong Long: Vanderbilt University Medical Center
Meng Sun: University of Oxford
Lin Tong: University of Chicago
Wei-Min Chen: University of Virginia School of Medicine
Suraj S. Nongmaithem: CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)
Raymond Noordam: Leiden University Medical Center
Victor J. Y. Lim: National University of Singapore and National University Health System
Claudia H. T. Tam: Chinese University of Hong Kong
Yoonjung Yoonie Joo: Sungkyunkwan University, Samsung Medical Center
Chien-Hsiun Chen: Academia Sinica
Laura M. Raffield: University of North Carolina at Chapel Hill
Bram Peter Prins: Wellcome Genome Campus
Aude Nicolas: National Institutes of Health
Lisa R. Yanek: Johns Hopkins University School of Medicine
Guanjie Chen: National Institutes of Health
Jennifer A. Brody: University of Washington
Edmond Kabagambe: Vanderbilt University Medical Center
Ping An: Washington University School of Medicine
Anny H. Xiang: Kaiser Permanente of Southern California
Hyeok Sun Choi: Hallym University
Brian E. Cade: Brigham and Women’s Hospital
Jingyi Tan: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
K. Alaine Broadaway: University of North Carolina at Chapel Hill
Alice Williamson: University of Cambridge School of Clinical Medicine
Zoha Kamali: University Medical Centre Groningen
Jinrui Cui: Cedars-Sinai Medical Center
Manonanthini Thangam: Lund University, Skåne University Hospital
Linda S. Adair: University of North Carolina at Chapel Hill
Adebowale Adeyemo: National Institutes of Health
Carlos A. Aguilar-Salinas: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Tarunveer S. Ahluwalia: Steno Diabetes Center Copenhagen
Sonia S. Anand: McMaster University
Alain Bertoni: Wake Forest School of Medicine
Jette Bork-Jensen: University of Copenhagen
Ivan Brandslund: University of Southern Denmark
Thomas A. Buchanan: Keck School of Medicine of USC
Charles F. Burant: University of Michigan
Adam S. Butterworth: University of Cambridge
Mickaël Canouil: Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital
Juliana C. N. Chan: Chinese University of Hong Kong
Li-Ching Chang: Academia Sinica
Miao-Li Chee: Singapore National Eye Centre
Ji Chen: University of Exeter
Shyh-Huei Chen: Wake Forest School of Medicine
Yuan-Tsong Chen: Academia Sinica
Zhengming Chen: University of Oxford
Lee-Ming Chuang: National Taiwan University Hospital
Mary Cushman: University of Vermont
John Danesh: University of Cambridge
Swapan K. Das: Wake Forest School of Medicine
H. Janaka Silva: University of Kelaniya
George Dedoussis: Harokopio University of Athens
Latchezar Dimitrov: Wake Forest School of Medicine
Ayo P. Doumatey: National Institutes of Health
Shufa Du: University of North Carolina at Chapel Hill
Qing Duan: University of North Carolina at Chapel Hill
Kai-Uwe Eckardt: Charité–Universitätsmedizin Berlin
Leslie S. Emery: University of Washington
Daniel S. Evans: California Pacific Medical Center Research Institute
Michele K. Evans: National Institutes of Health
Krista Fischer: University of Tartu
James S. Floyd: University of Washington
Ian Ford: University of Glasgow
Oscar H. Franco: Erasmus MC University Medical Center
Timothy M. Frayling: University of Exeter
Barry I. Freedman: Wake Forest School of Medicine
Pauline Genter: Lundquist Research Institute at Harbor-UCLA Medical Center
Hertzel C. Gerstein: McMaster University
Vilmantas Giedraitis: Uppsala University
Clicerio González-Villalpando: Instituto Nacional de Salud Publica
Maria Elena González-Villalpando: Instituto Nacional de Salud Publica
Penny Gordon-Larsen: University of North Carolina at Chapel Hill
Myron Gross: University of Minnesota
Lindsay A. Guare: University of Pennsylvania Perelman School of Medicine
Sophie Hackinger: Wellcome Genome Campus
Liisa Hakaste: University of Helsinki
Sohee Han: National Institute of Health
Andrew T. Hattersley: University of Exeter
Christian Herder: German Center for Diabetes Research (DZD)
Momoko Horikoshi: RIKEN Center for Integrative Medical Sciences
Annie-Green Howard: University of North Carolina at Chapel Hill
Willa Hsueh: Ohio State University Wexner Medical Center
Mengna Huang: Brown University School of Public Health
Wei Huang: Shanghai Institute for Biomedical and Pharmaceutical Technologies
Yi-Jen Hung: Tri-Service General Hospital Songshan Branch
Mi Yeong Hwang: National Institute of Health
Chii-Min Hwu: Taipei Veterans General Hospital
Sahoko Ichihara: Jichi Medical University School of Medicine
Mohammad Arfan Ikram: Erasmus MC University Medical Center
Martin Ingelsson: Uppsala University
Md. Tariqul Islam: University of Chicago Research Bangladesh
Masato Isono: National Center for Global Health and Medicine
Hye-Mi Jang: National Institute of Health
Farzana Jasmine: University of Chicago
Guozhi Jiang: Chinese University of Hong Kong
Jost B. Jonas: Institute of Molecular and Clinical Ophthalmology Basel
Torben Jørgensen: Bispebjerg and Frederiksberg Hospital
Frederick K. Kamanu: Harvard Medical School
Fouad R. Kandeel: City of Hope
Anuradhani Kasturiratne: University of Kelaniya
Tomohiro Katsuya: Osaka University Graduate School of Medicine
Varinderpal Kaur: Massachusetts General Hospital
Takahisa Kawaguchi: Kyoto University Graduate School of Medicine
Jacob M. Keaton: National Institutes of Health
Abel N. Kho: Northwestern University Feinberg School of Medicine
Chiea-Chuen Khor: Agency for Science, Technology and Research
Muhammad G. Kibriya: University of Chicago
Duk-Hwan Kim: Sungkyunkwan University School of Medicine
Florian Kronenberg: Medical University of Innsbruck
Johanna Kuusisto: University of Eastern Finland and Kuopio University Hospital
Kristi Läll: University of Tartu
Leslie A. Lange: University of Colorado Denver, Anschutz Medical Campus
Kyung Min Lee: VA Salt Lake City Health Care System
Myung-Shik Lee: Soochunhyang University College of Medicine
Nanette R. Lee: University of San Carlos
Aaron Leong: Harvard Medical School
Liming Li: Peking University
Yun Li: University of North Carolina at Chapel Hill
Ruifang Li-Gao: Leiden University Medical Center
Symen Ligthart: Erasmus MC University Medical Center
Cecilia M. Lindgren: University of Oxford
Allan Linneberg: Bispebjerg and Frederiksberg Hospital
Ching-Ti Liu: Boston University School of Public Health
Jianjun Liu: Agency for Science, Technology and Research
Adam E. Locke: Washington University School of Medicine
Tin Louie: University of Washington
Jian’an Luan: University of Cambridge School of Clinical Medicine
Andrea O. Luk: Chinese University of Hong Kong
Xi Luo: University of Texas Health Science Center at Houston School of Public Health
Jun Lv: Peking University
Julie A. Lynch: VA Salt Lake City Health Care System
Valeriya Lyssenko: Lund University Diabetes Centre
Shiro Maeda: RIKEN Center for Integrative Medical Sciences
Vasiliki Mamakou: National and Kapodistrian University of Athens
Sohail Rafik Mansuri: CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)
Koichi Matsuda: University of Tokyo
Thomas Meitinger: German Research Center for Environmental Health
Olle Melander: Lund University, Skåne University Hospital
Andres Metspalu: University of Tartu
Huan Mo: National Institutes of Health
Andrew D. Morris: University of Edinburgh
Filipe A. Moura: Harvard Medical School
Jerry L. Nadler: New York Medical College
Michael A. Nalls: National Institutes of Health
Uma Nayak: University of Virginia School of Medicine
Ioanna Ntalla: Queen Mary University of London
Yukinori Okada: Osaka University Graduate School of Medicine
Lorena Orozco: Instituto Nacional de Medicina Genómica
Sanjay R. Patel: University of Pittsburgh
Snehal Patil: University of Michigan
Pei Pei: Peking University Center for Public Health and Epidemic Preparedness and Response
Mark A. Pereira: University of Minnesota
Annette Peters: German Research Center for Environmental Health
Fraser J. Pirie: University of KwaZulu-Natal
Hannah G. Polikowsky: Vanderbilt University Medical Center
Bianca Porneala: Massachusetts General Hospital
Gauri Prasad: CSIR-Human Resource Development Campus
Laura J. Rasmussen-Torvik: Northwestern University Feinberg School of Medicine
Alexander P. Reiner: Fred Hutchinson Cancer Research Center
Michael Roden: German Center for Diabetes Research (DZD)
Rebecca Rohde: University of North Carolina at Chapel Hill
Katheryn Roll: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Charumathi Sabanayagam: Singapore National Eye Centre
Kevin Sandow: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Alagu Sankareswaran: CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)
Naveed Sattar: University of Glasgow
Sebastian Schönherr: Medical University of Innsbruck
Mohammad Shahriar: University of Chicago
Botong Shen: National Institutes of Health
Jinxiu Shi: Shanghai Institute for Biomedical and Pharmaceutical Technologies
Dong Mun Shin: National Institute of Health
Nobuhiro Shojima: University of Tokyo
Jennifer A. Smith: University of Michigan
Wing Yee So: Chinese University of Hong Kong
Alena Stančáková: University of Eastern Finland and Kuopio University Hospital
Valgerdur Steinthorsdottir: Amgen
Adrienne M. Stilp: University of Washington
Konstantin Strauch: German Research Center for Environmental Health
Kent D. Taylor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Barbara Thorand: German Research Center for Environmental Health
Unnur Thorsteinsdottir: Amgen
Brian Tomlinson: Chinese University of Hong Kong
Tam C. Tran: National Institutes of Health
Fuu-Jen Tsai: China Medical University Hospital
Jaakko Tuomilehto: Finnish Institute for Health and Welfare
Teresa Tusie-Luna: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Miriam S. Udler: Broad Institute of Harvard and MIT
Adan Valladares-Salgado: Instituto Mexicano del Seguro Social
Rob M. Dam: National University of Singapore and National University Health System
Jan B. Klinken: Leiden University Medical Center
Rohit Varma: CHA Hollywood Presbyterian Hospital
Niels Wacher-Rodarte: Instituto Mexicano del Seguro Social
Eleanor Wheeler: University of Cambridge School of Clinical Medicine
Ananda R. Wickremasinghe: University of Kelaniya
Ko Willems Dijk: Leiden University Medical Center
Daniel R. Witte: Aarhus University
Chittaranjan S. Yajnik: King Edward Memorial Hospital and Research Centre
Ken Yamamoto: Kurume University School of Medicine
Kenichi Yamamoto: Osaka University Graduate School of Medicine
Kyungheon Yoon: National Institute of Health
Canqing Yu: Peking University
Jian-Min Yuan: University of Pittsburgh
Salim Yusuf: McMaster University
Matthew Zawistowski: University of Michigan
Liang Zhang: Singapore National Eye Centre
Wei Zheng: Vanderbilt University Medical Center
Leslie J. Raffel: UCI Irvine School of Medicine
Michiya Igase: Ehime University Graduate School of Medicine
Eli Ipp: Lundquist Research Institute at Harbor-UCLA Medical Center
Susan Redline: Brigham and Women’s Hospital
Yoon Shin Cho: Hallym University
Lars Lind: Uppsala University
Michael A. Province: Washington University School of Medicine
Myriam Fornage: University of Texas Health Science Center at Houston School of Public Health
Craig L. Hanis: University of Texas Health Science Center at Houston
Erik Ingelsson: Stanford University School of Medicine
Alan B. Zonderman: National Institutes of Health
Bruce M. Psaty: University of Washington
Ya-Xing Wang: Capital Medical University
Charles N. Rotimi: National Institutes of Health
Diane M. Becker: Johns Hopkins University School of Medicine
Fumihiko Matsuda: Kyoto University Graduate School of Medicine
Yongmei Liu: Wake Forest School of Medicine
Mitsuhiro Yokota: Kurume University School of Medicine
Sharon L. R. Kardia: University of Michigan
Patricia A. Peyser: University of Michigan
James S. Pankow: University of Minnesota
James C. Engert: McGill University
Amélie Bonnefond: Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital
Philippe Froguel: Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital
James G. Wilson: Beth Israel Deaconess Medical Center
Wayne H. H. Sheu: National Defense Medical Center
Jer-Yuarn Wu: Academia Sinica
M. Geoffrey Hayes: Northwestern University Feinberg School of Medicine
Ronald C. W. Ma: Chinese University of Hong Kong
Tien-Yin Wong: Singapore National Eye Centre
Dennis O. Mook-Kanamori: Leiden University Medical Center
Tiinamaija Tuomi: Lund University, Skåne University Hospital
Giriraj R. Chandak: CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)
Francis S. Collins: National Institutes of Health
Dwaipayan Bharadwaj: Jawaharlal Nehru University
Guillaume Paré: Hamilton Health Sciences and McMaster University
Michèle M. Sale: University of Virginia School of Medicine
Habibul Ahsan: University of Chicago
Ayesha A. Motala: University of KwaZulu-Natal
Xiao-Ou Shu: Vanderbilt University Medical Center
Kyong-Soo Park: Seoul National University Hospital
J. Wouter Jukema: Leiden University Medical Center
Miguel Cruz: Instituto Mexicano del Seguro Social
Yii- Der Ida Chen: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Stephen S. Rich: University of Virginia School of Medicine
Roberta McKean-Cowdin: Keck School of Medicine of USC
Harald Grallert: German Research Center for Environmental Health
Ching-Yu Cheng: Singapore National Eye Centre
Mohsen Ghanbari: Erasmus MC University Medical Center
E-Shyong Tai: National University of Singapore and National University Health System
Josee Dupuis: Boston University School of Public Health
Norihiro Kato: National Center for Global Health and Medicine
Markku Laakso: University of Eastern Finland and Kuopio University Hospital
Anna Köttgen: University of Freiburg
Woon-Puay Koh: Agency for Science Technology and Research (A*STAR)
Donald W. Bowden: Wake Forest School of Medicine
Colin N. A. Palmer: University of Dundee
Jaspal S. Kooner: London NorthWest Healthcare NHS Trust
Charles Kooperberg: Fred Hutchinson Cancer Research Center
Simin Liu: Brown University School of Public Health
Kari E. North: University of North Carolina at Chapel Hill
Danish Saleheen: Columbia University Irving Medical Center
Torben Hansen: University of Copenhagen
Oluf Pedersen: University of Copenhagen
Nicholas J. Wareham: University of Cambridge School of Clinical Medicine
Juyoung Lee: National Institute of Health
Bong-Jo Kim: National Institute of Health
Iona Y. Millwood: University of Oxford
Robin G. Walters: University of Oxford
Kari Stefansson: Amgen
Emma Ahlqvist: Lund University, Skåne University Hospital
Mark O. Goodarzi: Cedars-Sinai Medical Center
Karen L. Mohlke: University of North Carolina at Chapel Hill
Claudia Langenberg: University of Cambridge School of Clinical Medicine
Christopher A. Haiman: Keck School of Medicine of USC
Ruth J. F. Loos: Icahn School of Medicine at Mount Sinai
Jose C. Florez: Broad Institute of Harvard and MIT
Daniel J. Rader: University of Pennsylvania Perelman School of Medicine
Marylyn D. Ritchie: University of Pennsylvania Perelman School of Medicine
Sebastian Zöllner: University of Michigan
Reedik Mägi: University of Tartu
Nicholas A. Marston: Harvard Medical School
Christian T. Ruff: Harvard Medical School
David A. Heel: Queen Mary University of London
Sarah Finer: Queen Mary University of London
Joshua C. Denny: National Institutes of Health
Toshimasa Yamauchi: University of Tokyo
Takashi Kadowaki: University of Tokyo
John C. Chambers: Imperial College London
Maggie C. Y. Ng: Wake Forest School of Medicine
Xueling Sim: National University of Singapore and National University Health System
Jennifer E. Below: Vanderbilt University Medical Center
Philip S. Tsao: Stanford University School of Medicine
Kyong-Mi Chang: Corporal Michael J. Crescenz VA Medical Center
Mark I. McCarthy: University of Oxford
James B. Meigs: Broad Institute of Harvard and MIT
Anubha Mahajan: University of Oxford
Cassandra N. Spracklen: University of Massachusetts Amherst
Josep M. Mercader: Broad Institute of Harvard and MIT
Michael Boehnke: University of Michigan
Jerome I. Rotter: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Marijana Vujkovic: Corporal Michael J. Crescenz VA Medical Center
Benjamin F. Voight: Corporal Michael J. Crescenz VA Medical Center
Andrew P. Morris: University of Manchester
Eleftheria Zeggini: German Research Center for Environmental Health

Nature, 2024, vol. 627, issue 8003, 347-357

Abstract: Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P

Date: 2024
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DOI: 10.1038/s41586-024-07019-6

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