Heat flows enrich prebiotic building blocks and enhance their reactivity

Thomas Matreux, Paula Aikkila, Bettina Scheu, Dieter Braun and Christof B. Mast ()
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Thomas Matreux: Ludwig-Maximilians-Universität München
Paula Aikkila: Ludwig-Maximilians-Universität München
Bettina Scheu: Ludwig-Maximilians-Universität München
Dieter Braun: Ludwig-Maximilians-Universität München
Christof B. Mast: Ludwig-Maximilians-Universität München

Nature, 2024, vol. 628, issue 8006, 110-116

Abstract: Abstract The emergence of biopolymer building blocks is a crucial step during the origins of life1–6. However, all known formation pathways rely on rare pure feedstocks and demand successive purification and mixing steps to suppress unwanted side reactions and enable high product yields. Here we show that heat flows through thin, crack-like geo-compartments could have provided a widely available yet selective mechanism that separates more than 50 prebiotically relevant building blocks from complex mixtures of amino acids, nucleobases, nucleotides, polyphosphates and 2-aminoazoles. Using measured thermophoretic properties7,8, we numerically model and experimentally prove the advantageous effect of geological networks of interconnected cracks9,10 that purify the previously mixed compounds, boosting their concentration ratios by up to three orders of magnitude. The importance for prebiotic chemistry is shown by the dimerization of glycine11,12, in which the selective purification of trimetaphosphate (TMP)13,14 increased reaction yields by five orders of magnitude. The observed effect is robust under various crack sizes, pH values, solvents and temperatures. Our results demonstrate how geologically driven non-equilibria could have explored highly parallelized reaction conditions to foster prebiotic chemistry.

Date: 2024
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DOI: 10.1038/s41586-024-07193-7

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