Multimodal cell atlas of the ageing human skeletal muscle

Yiwei Lai, Ignacio Ramírez-Pardo, Joan Isern, Juan An, Eusebio Perdiguero, Antonio L. Serrano, Jinxiu Li, Esther García-Domínguez, Jessica Segalés, Pengcheng Guo, Vera Lukesova, Eva Andrés, Jing Zuo, Yue Yuan, Chuanyu Liu, José Viña, Julio Doménech-Fernández, Mari Carmen Gómez-Cabrera, Yancheng Song, Longqi Liu, Xun Xu, Pura Muñoz-Cánoves () and Miguel A. Esteban ()
Additional contact information
Yiwei Lai: BGI Research
Ignacio Ramírez-Pardo: Universitat Pompeu Fabra (UPF)
Joan Isern: San Diego Institute of Science
Juan An: BGI Research
Eusebio Perdiguero: Universitat Pompeu Fabra (UPF)
Antonio L. Serrano: Universitat Pompeu Fabra (UPF)
Jinxiu Li: BGI Research
Esther García-Domínguez: University of Valencia and CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA
Jessica Segalés: Universitat Pompeu Fabra (UPF)
Pengcheng Guo: BGI Research
Vera Lukesova: Universitat Pompeu Fabra (UPF)
Eva Andrés: Universitat Pompeu Fabra (UPF)
Jing Zuo: BGI Research
Yue Yuan: BGI Research
Chuanyu Liu: BGI Research
José Viña: University of Valencia and CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA
Julio Doménech-Fernández: Hospital Arnau de Vilanova y Hospital de Liria and Health Care Department Arnau-Lliria
Mari Carmen Gómez-Cabrera: University of Valencia and CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA
Yancheng Song: The First Affiliated Hospital of Guangdong Pharmaceutical University
Longqi Liu: BGI Research
Xun Xu: BGI Research
Pura Muñoz-Cánoves: Universitat Pompeu Fabra (UPF)
Miguel A. Esteban: BGI Research

Nature, 2024, vol. 629, issue 8010, 154-164

Abstract: Abstract Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and are critical contributors to morbidity and mortality in older people1. Deciphering the molecular mechanisms underlying sarcopenia has major implications for understanding human ageing2. Yet, progress has been slow, partly due to the difficulties of characterizing skeletal muscle niche heterogeneity (whereby myofibres are the most abundant) and obtaining well-characterized human samples3,4. Here we generate a single-cell/single-nucleus transcriptomic and chromatin accessibility map of human limb skeletal muscles encompassing over 387,000 cells/nuclei from individuals aged 15 to 99 years with distinct fitness and frailty levels. We describe how cell populations change during ageing, including the emergence of new populations in older people, and the cell-specific and multicellular network features (at the transcriptomic and epigenetic levels) associated with these changes. On the basis of cross-comparison with genetic data, we also identify key elements of chromatin architecture that mark susceptibility to sarcopenia. Our study provides a basis for identifying targets in the skeletal muscle that are amenable to medical, pharmacological and lifestyle interventions in late life.

Date: 2024
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41586-024-07348-6 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:629:y:2024:i:8010:d:10.1038_s41586-024-07348-6

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-024-07348-6

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().