Injectable ultrasonic sensor for wireless monitoring of intracranial signals

Hanchuan Tang, Yueying Yang, Zhen Liu, Wenlong Li, Yipeng Zhang, Yizhou Huang, Tianyu Kang, Yang Yu, Na Li, Ye Tian, Xurui Liu, Yifan Cheng, Zhouping Yin, Xiaobing Jiang (), Xiaodong Chen () and Jianfeng Zang ()
Additional contact information
Hanchuan Tang: Huazhong University of Science and Technology
Yueying Yang: Huazhong University of Science and Technology
Zhen Liu: Huazhong University of Science and Technology
Wenlong Li: Technology and Research (A*STAR)
Yipeng Zhang: Huazhong University of Science and Technology
Yizhou Huang: Huazhong University of Science and Technology
Tianyu Kang: Huazhong University of Science and Technology
Yang Yu: Huazhong University of Science and Technology
Na Li: Huazhong University of Science and Technology
Ye Tian: Huazhong University of Science and Technology
Xurui Liu: Huazhong University of Science and Technology
Yifan Cheng: Huazhong University of Science and Technology
Zhouping Yin: Huazhong University of Science and Technology
Xiaobing Jiang: Huazhong University of Science and Technology
Xiaodong Chen: Nanyang Technological University
Jianfeng Zang: Huazhong University of Science and Technology

Nature, 2024, vol. 630, issue 8015, 84-90

Abstract: Abstract Direct and precise monitoring of intracranial physiology holds immense importance in delineating injuries, prognostication and averting disease1. Wired clinical instruments that use percutaneous leads are accurate but are susceptible to infection, patient mobility constraints and potential surgical complications during removal2. Wireless implantable devices provide greater operational freedom but include issues such as limited detection range, poor degradation and difficulty in size reduction in the human body3. Here we present an injectable, bioresorbable and wireless metastructured hydrogel (metagel) sensor for ultrasonic monitoring of intracranial signals. The metagel sensors are cubes 2 × 2 × 2 mm3 in size that encompass both biodegradable and stimulus-responsive hydrogels and periodically aligned air columns with a specific acoustic reflection spectrum. Implanted into intracranial space with a puncture needle, the metagel deforms in response to physiological environmental changes, causing peak frequency shifts of reflected ultrasound waves that can be wirelessly measured by an external ultrasound probe. The metagel sensor can independently detect intracranial pressure, temperature, pH and flow rate, realize a detection depth of 10 cm and almost fully degrade within 18 weeks. Animal experiments on rats and pigs indicate promising multiparametric sensing performances on a par with conventional non-resorbable wired clinical benchmarks.

Date: 2024
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DOI: 10.1038/s41586-024-07334-y

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