Life-cycle-coupled evolution of mitosis in close relatives of animals

Hiral Shah (), Marine Olivetta, Chandni Bhickta, Paolo Ronchi, Monika Trupinić, Eelco C. Tromer, Iva M. Tolić, Yannick Schwab, Omaya Dudin () and Gautam Dey ()
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Hiral Shah: European Molecular Biology Laboratory (EMBL)
Marine Olivetta: Swiss Federal Institute of Technology (EPFL)
Chandni Bhickta: European Molecular Biology Laboratory (EMBL)
Paolo Ronchi: European Molecular Biology Laboratory
Monika Trupinić: Ruđer Bošković Institute (RBI)
Eelco C. Tromer: University of Groningen
Iva M. Tolić: Ruđer Bošković Institute (RBI)
Yannick Schwab: European Molecular Biology Laboratory (EMBL)
Omaya Dudin: Swiss Federal Institute of Technology (EPFL)
Gautam Dey: European Molecular Biology Laboratory (EMBL)

Nature, 2024, vol. 630, issue 8015, 116-122

Abstract: Abstract Eukaryotes have evolved towards one of two extremes along a spectrum of strategies for remodelling the nuclear envelope during cell division: disassembling the nuclear envelope in an open mitosis or constructing an intranuclear spindle in a closed mitosis1,2. Both classes of mitotic remodelling involve key differences in the core division machinery but the evolutionary reasons for adopting a specific mechanism are unclear. Here we use an integrated comparative genomics and ultrastructural imaging approach to investigate mitotic strategies in Ichthyosporea, close relatives of animals and fungi. We show that species in this clade have diverged towards either a fungal-like closed mitosis or an animal-like open mitosis, probably to support distinct multinucleated or uninucleated states. Our results indicate that multinucleated life cycles favour the evolution of closed mitosis.

Date: 2024
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DOI: 10.1038/s41586-024-07430-z

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