Sleep loss diminishes hippocampal reactivation and replay

Bapun Giri, Nathaniel Kinsky, Utku Kaya, Kourosh Maboudi, Ted Abel and Kamran Diba ()
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Bapun Giri: University of Michigan Medical School
Nathaniel Kinsky: University of Michigan Medical School
Utku Kaya: University of Michigan Medical School
Kourosh Maboudi: University of Michigan Medical School
Ted Abel: University of Iowa
Kamran Diba: University of Michigan Medical School

Nature, 2024, vol. 630, issue 8018, 935-942

Abstract: Abstract Memories benefit from sleep1, and the reactivation and replay of waking experiences during hippocampal sharp-wave ripples (SWRs) are considered to be crucial for this process2. However, little is known about how these patterns are impacted by sleep loss. Here we recorded CA1 neuronal activity over 12 h in rats across maze exploration, sleep and sleep deprivation, followed by recovery sleep. We found that SWRs showed sustained or higher rates during sleep deprivation but with lower power and higher frequency ripples. Pyramidal cells exhibited sustained firing during sleep deprivation and reduced firing during sleep, yet their firing rates were comparable during SWRs regardless of sleep state. Despite the robust firing and abundance of SWRs during sleep deprivation, we found that the reactivation and replay of neuronal firing patterns was diminished during these periods and, in some cases, completely abolished compared to ad libitum sleep. Reactivation partially rebounded after recovery sleep but failed to reach the levels found in natural sleep. These results delineate the adverse consequences of sleep loss on hippocampal function at the network level and reveal a dissociation between the many SWRs elicited during sleep deprivation and the few reactivations and replays that occur during these events.

Date: 2024
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DOI: 10.1038/s41586-024-07538-2

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