Expanding chemistry through in vitro and in vivo biocatalysis

Elijah N. Kissman, Max B. Sosa, Douglas C. Millar, Edward J. Koleski, Kershanthen Thevasundaram and Michelle C. Y. Chang ()
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Elijah N. Kissman: University of California Berkeley
Max B. Sosa: University of California Berkeley
Douglas C. Millar: University of California Berkeley
Edward J. Koleski: University of California Berkeley
Kershanthen Thevasundaram: University of California Berkeley
Michelle C. Y. Chang: University of California Berkeley

Nature, 2024, vol. 631, issue 8019, 37-48

Abstract: Abstract Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes and cells as potential biocatalysts for chemical processes. The properties of protein and cell biocatalysts—high selectivity, the ability to control reaction sequence and operation in environmentally benign conditions—offer approaches to produce molecules at high efficiency while lowering the cost and environmental impact of industrial chemistry. Furthermore, biocatalysis offers the opportunity to generate chemical structures and functions that may be inaccessible to chemical synthesis. Here we consider developments in enzymes, biosynthetic pathways and cellular engineering that enable their use in catalysis for new chemistry and beyond.

Date: 2024
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DOI: 10.1038/s41586-024-07506-w

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