Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly

Jens Hör, Sharon G. Wolf and Rotem Sorek ()
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Jens Hör: Weizmann Institute of Science
Sharon G. Wolf: Weizmann Institute of Science
Rotem Sorek: Weizmann Institute of Science

Nature, 2024, vol. 631, issue 8022, 850-856

Abstract: Abstract Several immune pathways in humans conjugate ubiquitin-like proteins to virus and host molecules as a means of antiviral defence1–5. Here we studied an antiphage defence system in bacteria, comprising a ubiquitin-like protein, ubiquitin-conjugating enzymes E1 and E2, and a deubiquitinase. We show that during phage infection, this system specifically conjugates the ubiquitin-like protein to the phage central tail fibre, a protein at the tip of the tail that is essential for tail assembly as well as for recognition of the target host receptor. Following infection, cells encoding this defence system release a mixture of partially assembled, tailless phage particles and fully assembled phages in which the central tail fibre is obstructed by the covalently attached ubiquitin-like protein. These phages show severely impaired infectivity, explaining how the defence system protects the bacterial population from the spread of phage infection. Our findings demonstrate that conjugation of ubiquitin-like proteins is an antiviral strategy conserved across the tree of life.

Date: 2024
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DOI: 10.1038/s41586-024-07616-5

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