The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Overbey, Eliah G.; Kim, JangKeun; Tierney, Braden T.; Park, Jiwoon; Houerbi, Nadia; Lucaci, Alexander G.; Medina, Sebastian Garcia; Damle, Namita; Najjar, Deena; Grigorev, Kirill; Afshin, Evan E.; Ryon, Krista A.; Sienkiewicz, Karolina; Patras, Laura; Klotz, Remi; Ortiz, Veronica; MacKay, Matthew; Schweickart, Annalise; Chin, Christopher R.; Sierra, Maria A.; Valenzuela, Matias F.; Dantas, Ezequiel; Nelson, Theodore M.; Cekanaviciute, Egle; Deards, Gabriel; Foox, Jonathan; Narayanan, S. Anand; Schmidt, Caleb M.; Schmidt, Michael A.; Schmidt, Julian C.; Mullane, Sean; Tigchelaar, Seth Stravers; Levitte, Steven; Westover, Craig; Bhattacharya, Chandrima; Lucotti, Serena; Hirschberg, Jeremy Wain; Proszynski, Jacqueline; Burke, Marissa; Kleinman, Ashley S.; Butler, Daniel J.; Loy, Conor; Mzava, Omary; Lenz, Joan; Paul, Doru; Mozsary, Christopher; Sanders, Lauren M.; Taylor, Lynn E.; Patel, Chintan O.; Khan, Sharib A.; Mohamad, Mir Suhail; Byhaqui, Syed Gufran Ahmad; Aslam, Burhan; Gajadhar, Aaron S.; Williamson, Lucy; Tandel, Purvi; Yang, Qiu; Chu, Jessica; Benz, Ryan W.; Siddiqui, Asim; Hornburg, Daniel; Blease, Kelly; Moreno, Juan; Boddicker, Andrew; Zhao, Junhua; Lajoie, Bryan; Scott, Ryan T.; Gilbert, Rachel R.; Polo, San-huei Lai; Altomare, Andrew; Kruglyak, Semyon; Levy, Shawn; Ariyapala, Ishara; Beer, Joanne; Zhang, Bingqing; Hudson, Briana M.; Rininger, Aric; Church, Sarah E.; Beheshti, Afshin; Church, George M.; Smith, Scott M.; Crucian, Brian E.; Zwart, Sara R.; Matei, Irina; Lyden, David C.; Garrett-Bakelman, Francine; Krumsiek, Jan; Chen, Qiuying; Miller, Dawson; Shuga, Joe; Williams, Stephen; Nemec, Corey; Trudel, Guy; Pelchat, Martin; Laneuville, Odette; De Vlaminck, Iwijn; Gross, Steven; Bolton, Kelly L.; Bailey, Susan M.; Granstein, Richard; Furman, David; Melnick, Ari M.; Costes, Sylvain V.; Shirah, Bader; Yu, Min; Menon, Anil S.; Mateus, Jaime; Meydan, Cem; Mason, Christopher E.

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Eliah G. Overbey (), JangKeun Kim, Braden T. Tierney, Jiwoon Park, Nadia Houerbi, Alexander G. Lucaci, Sebastian Garcia Medina, Namita Damle, Deena Najjar, Kirill Grigorev, Evan E. Afshin, Krista A. Ryon, Karolina Sienkiewicz, Laura Patras, Remi Klotz, Veronica Ortiz, Matthew MacKay, Annalise Schweickart, Christopher R. Chin, Maria A. Sierra, Matias F. Valenzuela, Ezequiel Dantas, Theodore M. Nelson, Egle Cekanaviciute, Gabriel Deards, Jonathan Foox, S. Anand Narayanan, Caleb M. Schmidt, Michael A. Schmidt, Julian C. Schmidt, Sean Mullane, Seth Stravers Tigchelaar, Steven Levitte, Craig Westover, Chandrima Bhattacharya, Serena Lucotti, Jeremy Wain Hirschberg, Jacqueline Proszynski, Marissa Burke, Ashley S. Kleinman, Daniel J. Butler, Conor Loy, Omary Mzava, Joan Lenz, Doru Paul, Christopher Mozsary, Lauren M. Sanders, Lynn E. Taylor, Chintan O. Patel, Sharib A. Khan, Mir Suhail Mohamad, Syed Gufran Ahmad Byhaqui, Burhan Aslam, Aaron S. Gajadhar, Lucy Williamson, Purvi Tandel, Qiu Yang, Jessica Chu, Ryan W. Benz, Asim Siddiqui, Daniel Hornburg, Kelly Blease, Juan Moreno, Andrew Boddicker, Junhua Zhao, Bryan Lajoie, Ryan T. Scott, Rachel R. Gilbert, San-huei Lai Polo, Andrew Altomare, Semyon Kruglyak, Shawn Levy, Ishara Ariyapala, Joanne Beer, Bingqing Zhang, Briana M. Hudson, Aric Rininger, Sarah E. Church, Afshin Beheshti, George M. Church, Scott M. Smith, Brian E. Crucian, Sara R. Zwart, Irina Matei, David C. Lyden, Francine Garrett-Bakelman, Jan Krumsiek, Qiuying Chen, Dawson Miller, Joe Shuga, Stephen Williams, Corey Nemec, Guy Trudel, Martin Pelchat, Odette Laneuville, Iwijn De Vlaminck, Steven Gross, Kelly L. Bolton, Susan M. Bailey, Richard Granstein, David Furman, Ari M. Melnick, Sylvain V. Costes, Bader Shirah, Min Yu, Anil S. Menon, Jaime Mateus, Cem Meydan () and Christopher E. Mason ()
Additional contact information
Eliah G. Overbey: Weill Cornell Medicine
JangKeun Kim: Weill Cornell Medicine
Braden T. Tierney: Weill Cornell Medicine
Jiwoon Park: Weill Cornell Medicine
Nadia Houerbi: Weill Cornell Medicine
Alexander G. Lucaci: Weill Cornell Medicine
Sebastian Garcia Medina: Weill Cornell Medicine
Namita Damle: Weill Cornell Medicine
Deena Najjar: Albert Einstein College of Medicine
Kirill Grigorev: Weill Cornell Medicine
Evan E. Afshin: Weill Cornell Medicine
Krista A. Ryon: Weill Cornell Medicine
Karolina Sienkiewicz: Weill Cornell Medicine
Laura Patras: Weill Cornell Medicine
Remi Klotz: University of Southern California
Veronica Ortiz: University of Southern California
Matthew MacKay: Weill Cornell Medicine
Annalise Schweickart: Weill Cornell Medicine
Christopher R. Chin: Weill Cornell Medicine
Maria A. Sierra: Weill Cornell Medicine
Matias F. Valenzuela: Buck Institute for Research on Aging
Ezequiel Dantas: Weill Cornell Medicine
Theodore M. Nelson: Columbia University Irving Medical Center
Egle Cekanaviciute: NASA Ames Research Center
Gabriel Deards: Weill Cornell Medicine
Jonathan Foox: Weill Cornell Medicine
S. Anand Narayanan: Florida State University
Caleb M. Schmidt: Sovaris Aerospace
Michael A. Schmidt: Sovaris Aerospace
Julian C. Schmidt: Sovaris Aerospace
Sean Mullane: Space Exploration Technologies Corporation (SpaceX)
Seth Stravers Tigchelaar: Space Exploration Technologies Corporation (SpaceX)
Steven Levitte: Space Exploration Technologies Corporation (SpaceX)
Craig Westover: Weill Cornell Medicine
Chandrima Bhattacharya: Weill Cornell Medicine
Serena Lucotti: Weill Cornell Medicine
Jeremy Wain Hirschberg: Weill Cornell Medicine
Jacqueline Proszynski: Weill Cornell Medicine
Marissa Burke: Weill Cornell Medicine
Ashley S. Kleinman: Weill Cornell Medicine
Daniel J. Butler: Weill Cornell Medicine
Conor Loy: Cornell University
Omary Mzava: Cornell University
Joan Lenz: Cornell University
Doru Paul: Weill Cornell Medicine
Christopher Mozsary: Weill Cornell Medicine
Lauren M. Sanders: NASA Ames Research Center
Lynn E. Taylor: Colorado State University
Chintan O. Patel: TrialX Inc.
Sharib A. Khan: TrialX Inc.
Mir Suhail Mohamad: TrialX Inc.
Syed Gufran Ahmad Byhaqui: TrialX Inc.
Burhan Aslam: TrialX Inc.
Aaron S. Gajadhar: Seer Inc.
Lucy Williamson: Seer Inc.
Purvi Tandel: Seer Inc.
Qiu Yang: Seer Inc.
Jessica Chu: Seer Inc.
Ryan W. Benz: Seer Inc.
Asim Siddiqui: Seer Inc.
Daniel Hornburg: Seer Inc.
Kelly Blease: Element Biosciences
Juan Moreno: Element Biosciences
Andrew Boddicker: Element Biosciences
Junhua Zhao: Element Biosciences
Bryan Lajoie: Element Biosciences
Ryan T. Scott: NASA Ames Research Center
Rachel R. Gilbert: NASA Ames Research Center
San-huei Lai Polo: NASA Ames Research Center
Andrew Altomare: Element Biosciences
Semyon Kruglyak: Element Biosciences
Shawn Levy: Element Biosciences
Ishara Ariyapala: Alamar Biosciences Inc.
Joanne Beer: Alamar Biosciences Inc.
Bingqing Zhang: Alamar Biosciences Inc.
Briana M. Hudson: NanoString Technologies
Aric Rininger: NanoString Technologies
Sarah E. Church: NanoString Technologies
Afshin Beheshti: NASA Ames Research Center
George M. Church: Harvard Medical School and the Wyss Institute
Scott M. Smith: Biomedical Research and Environmental Sciences Division
Brian E. Crucian: Biomedical Research and Environmental Sciences Division
Sara R. Zwart: University of Texas Medical Branch
Irina Matei: Weill Cornell Medicine
David C. Lyden: Weill Cornell Medicine
Francine Garrett-Bakelman: University of Virginia
Jan Krumsiek: Weill Cornell Medicine
Qiuying Chen: Weill Cornell Medicine
Dawson Miller: Weill Cornell Medicine
Joe Shuga: 10x Genomics
Stephen Williams: 10x Genomics
Corey Nemec: 10x Genomics
Guy Trudel: Ottawa Hospital Research Institute
Martin Pelchat: University of Ottawa
Odette Laneuville: University of Ottawa
Iwijn De Vlaminck: Cornell University
Steven Gross: Weill Cornell Medicine
Kelly L. Bolton: Washington University School of Medicine
Susan M. Bailey: Colorado State University
Richard Granstein: Weill Cornell Medicine
David Furman: Buck Institute for Research on Aging
Ari M. Melnick: Weill Cornell Medicine
Sylvain V. Costes: NASA Ames Research Center
Bader Shirah: King Faisal Specialist Hospital and Research Centre
Min Yu: University of Southern California
Anil S. Menon: University of Texas Medical Branch
Jaime Mateus: Space Exploration Technologies Corporation (SpaceX)
Cem Meydan: Weill Cornell Medicine
Christopher E. Mason: Weill Cornell Medicine

Nature, 2024, vol. 632, issue 8027, 1145-1154

Abstract: Abstract Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1–6. Yet current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools and protocols. Here we present the Space Omics and Medical Atlas (SOMA), an integrated data and sample repository for clinical, cellular and multi-omic research profiles from a diverse range of missions, including the NASA Twins Study7, JAXA CFE study8,9, SpaceX Inspiration4 crew10–12, Axiom and Polaris. The SOMA resource represents a more than tenfold increase in publicly available human space omics data, with matched samples available from the Cornell Aerospace Medicine Biobank. The Atlas includes extensive molecular and physiological profiles encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics and microbiome datasets, which reveal some consistent features across missions, including cytokine shifts, telomere elongation and gene expression changes, as well as mission-specific molecular responses and links to orthologous, tissue-specific mouse datasets. Leveraging the datasets, tools and resources in SOMA can help to accelerate precision aerospace medicine, bringing needed health monitoring, risk mitigation and countermeasure data for upcoming lunar, Mars and exploration-class missions.

Date: 2024
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DOI: 10.1038/s41586-024-07639-y

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