Frontostriatal salience network expansion in individuals in depression

Charles J. Lynch (), Immanuel G. Elbau, Tommy Ng, Aliza Ayaz, Shasha Zhu, Danielle Wolk, Nicola Manfredi, Megan Johnson, Megan Chang, Jolin Chou, Indira Summerville, Claire Ho, Maximilian Lueckel, Hussain Bukhari, Derrick Buchanan, Lindsay W. Victoria, Nili Solomonov, Eric Goldwaser, Stefano Moia, Cesar Caballero-Gaudes, Jonathan Downar, Fidel Vila-Rodriguez, Zafiris J. Daskalakis, Daniel M. Blumberger, Kendrick Kay, Amy Aloysi, Evan M. Gordon, Mahendra T. Bhati, Nolan Williams, Jonathan D. Power, Benjamin Zebley, Logan Grosenick, Faith M. Gunning and Conor Liston ()
Additional contact information
Charles J. Lynch: Weill Cornell Medicine
Immanuel G. Elbau: Weill Cornell Medicine
Tommy Ng: Weill Cornell Medicine
Aliza Ayaz: Weill Cornell Medicine
Shasha Zhu: Weill Cornell Medicine
Danielle Wolk: Weill Cornell Medicine
Nicola Manfredi: Weill Cornell Medicine
Megan Johnson: Weill Cornell Medicine
Megan Chang: Weill Cornell Medicine
Jolin Chou: Weill Cornell Medicine
Indira Summerville: Weill Cornell Medicine
Claire Ho: Weill Cornell Medicine
Maximilian Lueckel: Leibniz Institute for Resilience Research
Hussain Bukhari: Weill Cornell Medicine
Derrick Buchanan: Stanford University
Lindsay W. Victoria: Weill Cornell Medicine
Nili Solomonov: Weill Cornell Medicine
Eric Goldwaser: Weill Cornell Medicine
Stefano Moia: École Polytechnique Fédérale de Lausanne
Cesar Caballero-Gaudes: Basque Center on Cognition, Brain and Language
Jonathan Downar: University of Toronto
Fidel Vila-Rodriguez: University of British Columbia
Zafiris J. Daskalakis: University of California
Daniel M. Blumberger: University of Toronto
Kendrick Kay: University of Minnesota
Amy Aloysi: Icahn School of Medicine at Mount Sinai
Evan M. Gordon: Washington University School of Medicine
Mahendra T. Bhati: Stanford University
Nolan Williams: Stanford University
Jonathan D. Power: Weill Cornell Medicine
Benjamin Zebley: Weill Cornell Medicine
Logan Grosenick: Weill Cornell Medicine
Faith M. Gunning: Weill Cornell Medicine
Conor Liston: Weill Cornell Medicine

Nature, 2024, vol. 633, issue 8030, 624-633

Abstract: Abstract Decades of neuroimaging studies have shown modest differences in brain structure and connectivity in depression, hindering mechanistic insights or the identification of risk factors for disease onset1. Furthermore, whereas depression is episodic, few longitudinal neuroimaging studies exist, limiting understanding of mechanisms that drive mood-state transitions. The emerging field of precision functional mapping has used densely sampled longitudinal neuroimaging data to show behaviourally meaningful differences in brain network topography and connectivity between and in healthy individuals2–4, but this approach has not been applied in depression. Here, using precision functional mapping and several samples of deeply sampled individuals, we found that the frontostriatal salience network is expanded nearly twofold in the cortex of most individuals with depression. This effect was replicable in several samples and caused primarily by network border shifts, with three distinct modes of encroachment occurring in different individuals. Salience network expansion was stable over time, unaffected by mood state and detectable in children before the onset of depression later in adolescence. Longitudinal analyses of individuals scanned up to 62 times over 1.5 years identified connectivity changes in frontostriatal circuits that tracked fluctuations in specific symptoms and predicted future anhedonia symptoms. Together, these findings identify a trait-like brain network topology that may confer risk for depression and mood-state-dependent connectivity changes in frontostriatal circuits that predict the emergence and remission of depressive symptoms over time.

Date: 2024
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DOI: 10.1038/s41586-024-07805-2

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