Neuronal wiring diagram of an adult brain

Sven Dorkenwald, Arie Matsliah, Amy R. Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin, Will Silversmith, Casey Schneider-Mizell, Chris S. Jordan, Derrick Brittain, Akhilesh Halageri, Kai Kuehner, Oluwaseun Ogedengbe, Ryan Morey, Jay Gager, Krzysztof Kruk, Eric Perlman, Runzhe Yang, David Deutsch, Doug Bland, Marissa Sorek, Ran Lu, Thomas Macrina, Kisuk Lee, J. Alexander Bae, Shang Mu, Barak Nehoran, Eric Mitchell, Sergiy Popovych, Jingpeng Wu, Zhen Jia, Manuel A. Castro, Nico Kemnitz, Dodam Ih, Alexander Shakeel Bates, Nils Eckstein, Jan Funke, Forrest Collman, Davi D. Bock, Gregory S. X. E. Jefferis, H. Sebastian Seung () and Mala Murthy ()
Additional contact information
Sven Dorkenwald: Princeton University
Arie Matsliah: Princeton University
Amy R. Sterling: Princeton University
Philipp Schlegel: MRC Laboratory of Molecular Biology
Szi-chieh Yu: Princeton University
Claire E. McKellar: Princeton University
Albert Lin: Princeton University
Marta Costa: University of Cambridge
Katharina Eichler: University of Cambridge
Yijie Yin: University of Cambridge
Will Silversmith: Princeton University
Casey Schneider-Mizell: Allen Institute for Brain Science
Chris S. Jordan: Princeton University
Derrick Brittain: Allen Institute for Brain Science
Akhilesh Halageri: Princeton University
Kai Kuehner: Princeton University
Oluwaseun Ogedengbe: Princeton University
Ryan Morey: Princeton University
Jay Gager: Princeton University
Krzysztof Kruk: Eyewire
Eric Perlman: Yikes LLC
Runzhe Yang: Princeton University
David Deutsch: Princeton University
Doug Bland: Princeton University
Marissa Sorek: Princeton University
Ran Lu: Princeton University
Thomas Macrina: Princeton University
Kisuk Lee: Princeton University
J. Alexander Bae: Princeton University
Shang Mu: Princeton University
Barak Nehoran: Princeton University
Eric Mitchell: Princeton University
Sergiy Popovych: Princeton University
Jingpeng Wu: Princeton University
Zhen Jia: Princeton University
Manuel A. Castro: Princeton University
Nico Kemnitz: Princeton University
Dodam Ih: Princeton University
Alexander Shakeel Bates: MRC Laboratory of Molecular Biology
Nils Eckstein: Howard Hughes Medical Institute
Jan Funke: Howard Hughes Medical Institute
Forrest Collman: Allen Institute for Brain Science
Davi D. Bock: University of Vermont
Gregory S. X. E. Jefferis: MRC Laboratory of Molecular Biology
H. Sebastian Seung: Princeton University
Mala Murthy: Princeton University

Nature, 2024, vol. 634, issue 8032, 124-138

Abstract: Abstract Connections between neurons can be mapped by acquiring and analysing electron microscopic brain images. In recent years, this approach has been applied to chunks of brains to reconstruct local connectivity maps that are highly informative1–6, but nevertheless inadequate for understanding brain function more globally. Here we present a neuronal wiring diagram of a whole brain containing 5 × 107 chemical synapses7 between 139,255 neurons reconstructed from an adult female Drosophila melanogaster8,9. The resource also incorporates annotations of cell classes and types, nerves, hemilineages and predictions of neurotransmitter identities10–12. Data products are available for download, programmatic access and interactive browsing and have been made interoperable with other fly data resources. We derive a projectome—a map of projections between regions—from the connectome and report on tracing of synaptic pathways and the analysis of information flow from inputs (sensory and ascending neurons) to outputs (motor, endocrine and descending neurons) across both hemispheres and between the central brain and the optic lobes. Tracing from a subset of photoreceptors to descending motor pathways illustrates how structure can uncover putative circuit mechanisms underlying sensorimotor behaviours. The technologies and open ecosystem reported here set the stage for future large-scale connectome projects in other species.

Date: 2024
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DOI: 10.1038/s41586-024-07558-y

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