Mineralized collagen plywood contributes to bone autograft performance

Marc Robin, Elodie Mouloungui, Gabriel Castillo Dali, Yan Wang, Jean-Louis Saffar, Graciela Pavon-Djavid, Thibaut Divoux, Sébastien Manneville, Luc Behr, Delphine Cardi, Laurence Choudat, Marie-Madeleine Giraud-Guille, Anne Meddahi-Pellé, Fannie Baudimont, Marie-Laure Colombier and Nadine Nassif ()
Additional contact information
Marc Robin: Sorbonne Université, CNRS, Collège de France
Elodie Mouloungui: Sorbonne Université, CNRS, Collège de France
Gabriel Castillo Dali: UFR d’Odontologie, Université Paris Cité
Yan Wang: Sorbonne Université, CNRS, Collège de France
Jean-Louis Saffar: UFR d’Odontologie, Université Paris Cité
Graciela Pavon-Djavid: Université Sorbonne Paris Nord, Inserm U1148
Thibaut Divoux: Laboratoire de Physique, ENSL, CNRS
Sébastien Manneville: Laboratoire de Physique, ENSL, CNRS
Luc Behr: IMM Recherche
Delphine Cardi: SATT Lutech
Laurence Choudat: Hôpital Bichat
Marie-Madeleine Giraud-Guille: Sorbonne Université, CNRS, Collège de France
Anne Meddahi-Pellé: Université Sorbonne Paris Nord, Inserm U1148
Fannie Baudimont: ABS Atlantic Bone Screen
Marie-Laure Colombier: UFR d’Odontologie, Université Paris Cité
Nadine Nassif: Sorbonne Université, CNRS, Collège de France

Nature, 2024, vol. 636, issue 8041, 100-107

Abstract: Abstract Autologous bone (AB) is the gold standard for bone-replacement surgeries1, despite its limited availability and the need for an extra surgical site. Traditionally, competitive biomaterials for bone repair have focused on mimicking the mineral aspect of bone, as evidenced by the widespread clinical use of bioactive ceramics2. However, AB also exhibits hierarchical organic structures that might substantially affect bone regeneration. Here, using a range of cell-free biomimetic-collagen-based materials in murine and ovine bone-defect models, we demonstrate that a hierarchical hybrid microstructure—specifically, the twisted plywood pattern of collagen and its association with poorly crystallized bioapatite—favourably influences bone regeneration. Our study shows that the most structurally biomimetic material has the potential to stimulate bone growth, highlighting the pivotal role of physicochemical properties in supporting bone formation and offering promising prospects as a competitive bone-graft material.

Date: 2024
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DOI: 10.1038/s41586-024-08208-z

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