Spatially restricted immune and microbiota-driven adaptation of the gut

Toufic Mayassi, Chenhao Li, Åsa Segerstolpe, Eric M. Brown, Rebecca Weisberg, Toru Nakata, Hiroshi Yano, Paula Herbst, David Artis, Daniel B. Graham and Ramnik J. Xavier ()
Additional contact information
Toufic Mayassi: Broad Institute of MIT and Harvard
Chenhao Li: Broad Institute of MIT and Harvard
Åsa Segerstolpe: Broad Institute of MIT and Harvard
Eric M. Brown: Broad Institute of MIT and Harvard
Rebecca Weisberg: Broad Institute of MIT and Harvard
Toru Nakata: Massachusetts General Hospital and Harvard Medical School
Hiroshi Yano: Cornell University
Paula Herbst: Massachusetts General Hospital and Harvard Medical School
David Artis: Cornell University
Daniel B. Graham: Broad Institute of MIT and Harvard
Ramnik J. Xavier: Broad Institute of MIT and Harvard

Nature, 2024, vol. 636, issue 8042, 447-456

Abstract: Abstract The intestine is characterized by an environment in which host requirements for nutrient and water absorption are consequently paired with the requirements to establish tolerance to the outside environment. To better understand how the intestine functions in health and disease, large efforts have been made to characterize the identity and composition of cells from different intestinal regions1–8. However, the robustness, nature of adaptability and extent of resilience of the transcriptional landscape and cellular underpinning of the intestine in space are still poorly understood. Here we generated an integrated resource of the spatial and cellular landscape of the murine intestine in the steady and perturbed states. Leveraging these data, we demonstrated that the spatial landscape of the intestine was robust to the influence of the microbiota and was adaptable in a spatially restricted manner. Deploying a model of spatiotemporal acute inflammation, we demonstrated that both robust and adaptable features of the landscape were resilient. Moreover, highlighting the physiological relevance and value of our dataset, we identified a region of the middle colon characterized by an immune-driven multicellular spatial adaptation of structural cells to the microbiota. Our results demonstrate that intestinal regionalization is characterized by robust and resilient structural cell states and that the intestine can adapt to environmental stress in a spatially controlled manner through the crosstalk between immunity and structural cell homeostasis.

Date: 2024
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41586-024-08216-z Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:636:y:2024:i:8042:d:10.1038_s41586-024-08216-z

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-024-08216-z

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().