Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

Max L. Valenstein (), Pranav V. Lalgudi, Jibril F. Kedir, Kendall J. Condon, Anna Platzek, Daniel G. Freund, Martin S. Taylor, Yunhan Xu, Raghu R. Chivukula and David M. Sabatini
Additional contact information
Max L. Valenstein: Massachusetts General Hospital
Pranav V. Lalgudi: Whitehead Institute for Biomedical Research
Jibril F. Kedir: Whitehead Institute for Biomedical Research
Kendall J. Condon: Whitehead Institute for Biomedical Research
Anna Platzek: Whitehead Institute for Biomedical Research
Daniel G. Freund: Whitehead Institute for Biomedical Research
Martin S. Taylor: Harvard Medical School
Yunhan Xu: Massachusetts General Hospital
Raghu R. Chivukula: Massachusetts General Hospital
David M. Sabatini: Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Nature, 2025, vol. 637, issue 8045, E11-E14

Date: 2025
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DOI: 10.1038/s41586-024-07974-0

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