Light-harvesting microelectronic devices for wireless electrosynthesis

Bartosz Górski, Jonas Rein, Samantha Norris, Yanxin Ji, Paul L. McEuen () and Song Lin ()
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Bartosz Górski: Cornell University
Jonas Rein: Cornell University
Samantha Norris: Cornell University
Yanxin Ji: Cornell University
Paul L. McEuen: Cornell University
Song Lin: Cornell University

Nature, 2025, vol. 637, issue 8045, 354-361

Abstract: Abstract High-throughput experimentation (HTE) has accelerated academic and industrial chemical research in reaction development and drug discovery and has been broadly applied in many domains of organic chemistry1,2. However, application of HTE in electrosynthesis—an enabling tool for chemical synthesis—has been limited by a dearth of suitable standardized reactors3–7. Here we report the development of microelectronic devices, which are produced using standard nanofabrication techniques, to enable wireless electrosynthesis on the microlitre scale. These robust and inexpensive devices are powered by visible light and convert any traditional 96-well or 384-well plate into an electrochemical reactor. We validate the devices in oxidative, reductive and paired electrolysis and further apply them to achieve the library synthesis of biologically active compounds and accelerate the development of two electrosynthetic methodologies. We anticipate that, by simplifying the way electrochemical reactions are set up, this user-friendly solution will not only enhance the experience and efficiency of current practitioners but also substantially reduce the barrier for nonspecialists to enter the field of electrosynthesis, thus allowing the broader community of synthetic chemists to explore and benefit from new reactivities and synthetic strategies enabled by electrochemistry8–12.

Date: 2025
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DOI: 10.1038/s41586-024-08373-1

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