Perception of viral infections and initiation of antiviral defence in rice

Yu Huang, Jialin Yang, Xi Sun, Jiahao Li, Xiaoqiang Cao, Shengze Yao, Yanhong Han, Changtian Chen, Linlin Du, Shuo Li, Yinghua Ji, Tong Zhou, He Wang, Jia-jia Han, Wenming Wang, Chunhong Wei, Qi Xie, Zhirui Yang () and Yi Li ()
Additional contact information
Yu Huang: Peking University
Jialin Yang: Peking University
Xi Sun: Peking University
Jiahao Li: Peking University
Xiaoqiang Cao: Chinese Academy of Sciences
Shengze Yao: Peking University
Yanhong Han: Fujian Agriculture and Forestry University
Changtian Chen: Fujian Agriculture and Forestry University
Linlin Du: Jiangsu Academy of Agricultural Sciences
Shuo Li: Jiangsu Academy of Agricultural Sciences
Yinghua Ji: Jiangsu Academy of Agricultural Sciences
Tong Zhou: Jiangsu Academy of Agricultural Sciences
He Wang: Sichuan Agricultural University
Jia-jia Han: School of Ecology and Environmental Science Yunnan University
Wenming Wang: Sichuan Agricultural University
Chunhong Wei: Peking University
Qi Xie: Chinese Academy of Sciences
Zhirui Yang: China Agricultural University
Yi Li: Peking University

Nature, 2025, vol. 641, issue 8061, 173-181

Abstract: Abstract Crop production faces persistent threats from insect-vector-borne viral diseases1,2. Recent advancements have revealed the intricate immune mechanisms that plants deploy against viral pathogens3–8. However, the molecular mechanisms through which plant hosts recognize viral infections and initiate antiviral defence at disease onset have not been elucidated. Here, through the natural infection of rice by inoculation with insect vectors carrying the natural forms of viruses, we show that viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase (RBRL), initiating the first step of the natural antiviral response in rice. RBRL subsequently targets an adaptor protein of the transcriptional repression complex of the jasmonate pathway, NOVEL INTERACTOR OF JAZ 3 (NINJA3), for degradation through the ubiquitination system, inducing jasmonate signalling and activating downstream antiviral defence. We further show that this phenomenon is a universal molecular mechanism used by rice plants to perceive viral infections and initiate antiviral signalling cascades. This approach is important not only for obtaining a deeper understanding of virus–host interactions but also for further disease resistance breeding.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41586-025-08706-8 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:641:y:2025:i:8061:d:10.1038_s41586-025-08706-8

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-025-08706-8

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().