Sleep pressure accumulates in a voltage-gated lipid peroxidation memory

H. Olof Rorsman, Max A. Müller, Patrick Z. Liu, Laura Garmendia Sanchez, Anissa Kempf, Stefanie Gerbig, Bernhard Spengler and Gero Miesenböck ()
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H. Olof Rorsman: University of Oxford
Max A. Müller: Justus-Liebig-Universität
Patrick Z. Liu: University of Oxford
Laura Garmendia Sanchez: University of Oxford
Anissa Kempf: University of Oxford
Stefanie Gerbig: Justus-Liebig-Universität
Bernhard Spengler: Justus-Liebig-Universität
Gero Miesenböck: University of Oxford

Nature, 2025, vol. 641, issue 8061, 232-239

Abstract: Abstract Voltage-gated potassium (KV) channels contain cytoplasmically exposed β-subunits1–5 whose aldo-keto reductase activity6–8 is required for the homeostatic regulation of sleep9. Here we show that Hyperkinetic, the β-subunit of the KV1 channel Shaker in Drosophila7, forms a dynamic lipid peroxidation memory. Information is stored in the oxidation state of Hyperkinetic’s nicotinamide adenine dinucleotide phosphate (NADPH) cofactor, which changes when lipid-derived carbonyls10–13, such as 4-oxo-2-nonenal or an endogenous analogue generated by illuminating a membrane-bound photosensitizer9,14, abstract an electron pair. NADP+ remains locked in the active site of KVβ until membrane depolarization permits its release and replacement with NADPH. Sleep-inducing neurons15–17 use this voltage-gated oxidoreductase cycle to encode their recent lipid peroxidation history in the collective binary states of their KVβ subunits; this biochemical memory influences—and is erased by—spike discharges driving sleep. The presence of a lipid peroxidation sensor at the core of homeostatic sleep control16,17 suggests that sleep protects neuronal membranes against oxidative damage. Indeed, brain phospholipids are depleted of vulnerable polyunsaturated fatty acyl chains after enforced waking, and slowing the removal of their carbonylic breakdown products increases the demand for sleep.

Date: 2025
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DOI: 10.1038/s41586-025-08734-4

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