 Connectome-driven neural inventory of a complete visual systemAljoscha Nern,
Frank Loesche,
Shin-ya Takemura,
Laura E. Burnett,
Marisa Dreher,
Eyal Gruntman,
Judith Hoeller,
Gary B. Huang,
Michał Januszewski,
Nathan C. Klapoetke,
Sanna Koskela,
Kit D. Longden,
Zhiyuan Lu,
Stephan Preibisch,
Wei Qiu,
Edward M. Rogers,
Pavithraa Seenivasan,
Arthur Zhao,
John Bogovic,
Brandon S. Canino,
Jody Clements,
Michael Cook,
Samantha Finley-May,
Miriam A. Flynn,
Imran Hameed,
Alexandra M. C. Fragniere,
Kenneth J. Hayworth,
Gary Patrick Hopkins,
Philip M. Hubbard,
William T. Katz,
Julie Kovalyak,
Shirley A. Lauchie,
Meghan Leonard,
Alanna Lohff,
Charli A. Maldonado,
Caroline Mooney,
Nneoma Okeoma,
Donald J. Olbris,
Christopher Ordish,
Tyler Paterson,
Emily M. Phillips,
Tobias Pietzsch,
Jennifer Rivas Salinas,
Patricia K. Rivlin,
Philipp Schlegel,
Ashley L. Scott,
Louis A. Scuderi,
Satoko Takemura,
Iris Talebi,
Alexander Thomson,
Eric T. Trautman,
Lowell Umayam,
Claire Walsh,
John J. Walsh,
C. Shan Xu,
Emily A. Yakal,
Tansy Yang,
Ting Zhao,
Jan Funke,
Reed George,
Harald F. Hess,
Gregory S. X. E. Jefferis,
Christopher Knecht,
Wyatt Korff,
Stephen M. Plaza,
Sandro Romani,
Stephan Saalfeld,
Louis K. Scheffer,
Stuart Berg (),
Gerald M. Rubin () and
Michael B. Reiser ()
Nature, 2025, vol. 641, issue 8065, 1225-1237 Abstract: Abstract Vision provides animals with detailed information about their surroundings and conveys diverse features such as colour, form and movement across the visual scene. Computing these parallel spatial features requires a large and diverse network of neurons. Consequently, from flies to humans, visual regions in the brain constitute half its volume. These visual regions often have marked structure–function relationships, with neurons organized along spatial maps and with shapes that directly relate to their roles in visual processing. More than a century of anatomical studies have catalogued in detail cell types in fly visual systems1–3, and parallel behavioural and physiological experiments have examined the visual capabilities of flies. To unravel the diversity of a complex visual system, careful mapping of the neural architecture matched to tools for targeted exploration of this circuitry is essential. Here we present a connectome of the right optic lobe from a male Drosophila melanogaster acquired using focused ion beam milling and scanning electron microscopy. We established a comprehensive inventory of the visual neurons and developed a computational framework to quantify their anatomy. Together, these data establish a basis for interpreting how the shapes of visual neurons relate to spatial vision. By integrating this analysis with connectivity information, neurotransmitter identity and expert curation, we classified the approximately 53,000 neurons into 732 types. These types are systematically described and about half are newly named. Finally, we share an extensive collection of split-GAL4 lines matched to our neuron-type catalogue. Overall, this comprehensive set of tools and data unlocks new possibilities for systematic investigations of vision in Drosophila and provides a foundation for a deeper understanding of sensory processing. Date: 2025 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:641:y:2025:i:8065:d:10.1038_s41586-025-08746-0 Ordering information: This journal article can be ordered from DOI: 10.1038/s41586-025-08746-0 Access Statistics for this article Nature is currently edited by Magdalena Skipper More articles in Nature from Nature |
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