Hippocampal representations drift in stable multisensory environments

Jason R. Climer, Heydar Davoudi, Jun Young Oh and Daniel A. Dombeck ()
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Jason R. Climer: Northwestern University
Heydar Davoudi: Northwestern University
Jun Young Oh: Northwestern University
Daniel A. Dombeck: Northwestern University

Nature, 2025, vol. 645, issue 8080, 457-465

Abstract: Abstract Experiments that track hippocampal place cells in mice navigating the same real environment have found significant changes in neural representations over a period of days1,2. However, whether such ‘representational drift’ serves an intrinsic function, such as distinguishing similar experiences that occur at different times3,4, or is instead observed due to subtle differences in the sensory environment or behaviour5–7, remains unresolved. Here we used the experimental control offered by a multisensory virtual reality system to determine that differences in sensory environment or behaviour do not detectably change drift rate. We also found that the excitability of individual place cells was most predictive of their representational drift over subsequent days, with more excitable cells exhibiting less drift. These findings establish that representational drift occurs in mice even with highly reproducible environments and behaviour and highlight neuronal excitability as a key factor of long-term representational stability.

Date: 2025
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DOI: 10.1038/s41586-025-09245-y

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