On the inefficiency of the adaptive design for monitoring clinical trials

Anastasios A. Tsiatis

Biometrika, 2003, vol. 90, issue 2, 367-378

Abstract: Adaptive designs, which allow the sample size to be modified based on sequentially computed observed treatment differences, have been advocated recently for monitoring clinical trials. Although such methods have a great deal of appeal on the surface, we show that such methods are inefficient and that one can improve uniformly on such adaptive designs using standard group-sequential tests based on the sequentially computed likelihood ratio test statistic. Copyright Biometrika Trust 2003, Oxford University Press.

Date: 2003
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