Nonparametric estimation of age-at-onset distributions from censored kin-cohort data

Yuanjia Wang, Lorraine N. Clark, Karen Marder and Daniel Rabinowitz

Biometrika, 2007, vol. 94, issue 2, 403-114

Abstract: We present a nonparametric estimator of genotype-specific age-at-onset distributions from kin-cohort data. Standard error calculations are derived and the methodology is illustrated through an analysis of the influence of mutations of the Parkin gene on Parkinson's disease. Semiparametric efficiency considerations are briefly discussed. Copyright 2007, Oxford University Press.

Date: 2007
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