Optimal designs for the emax, log-linear and exponential models

H. Dette, C. Kiss, M. Bevanda and F. Bretz

Biometrika, 2010, vol. 97, issue 2, 513-518

Abstract: We derive locally D- and ED p -optimal designs for the exponential, log-linear and three-parameter emax models. For each model the locally D- and ED p -optimal designs are supported at the same set of points, while the corresponding weights are different. This indicates that for a given model, D-optimal designs are efficient for estimating the smallest dose that achieves 100p% of the maximum effect in the observed dose range. Conversely, ED p -optimal designs also yield good D-efficiencies. We illustrate the results using several examples and demonstrate that locally D- and ED p -optimal designs for the emax, log-linear and exponential models are relatively robust with respect to misspecification of the model parameters. Copyright 2010, Oxford University Press.

Date: 2010
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