Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study

Correne A. DeCarlo, Stuart W. S. MacDonald, David Vergote, Jack Jhamandas, David Westaway and Roger A. Dixon

The Journals of Gerontology: Series B, 2016, vol. 71, issue 6, 1004-1014

Abstract: Objectives. Mild cognitive impairment (MCI) is a high-risk condition for progression to Alzheimer’s disease (AD). Vascular health is a key mechanism underlying age-related cognitive decline and neurodegeneration. AD-related genetic risk factors may be associated with preclinical cognitive status changes. We examine independent and cross-domain interactive effects of vascular and genetic markers for predicting MCI status and stability.

Date: 2016
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