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Loneliness and Risk of Dementia

Angelina R SutinPhD, Yannick StephanPhD, Martina LuchettiPhD, Antonio TerraccianoPhD and Lynn MartirePhD

The Journals of Gerontology: Series B, 2020, vol. 75, issue 7, 1414-1422

Abstract: ObjectiveThe present study tests whether loneliness is associated with risk of dementia in the largest sample to date and further examines whether the association is independent of social isolation, a related but independent component of social integration, and whether it varies by demographic factors and genetic vulnerability.MethodParticipants from the Health and Retirement Study (N = 12,030) reported on their loneliness, social isolation, and had information on clinical, behavioral, and genetic risk factors. Cognitive status was assessed at baseline and every 2 years over a 10-year follow-up with the modified Telephone Interview for Cognitive Status (TICSm). A TICSm score of 6 or less was indicative of dementia.ResultsCox proportional hazards regression indicated that loneliness was associated with a 40% increased risk of dementia. This association held controlling for social isolation, and clinical, behavioral, and genetic risk factors. The association was similar across gender, race, ethnicity, education, and genetic risk.DiscussionLoneliness is associated with increased risk of dementia. It is one modifiable factor that can be intervened on to reduce dementia risk.

Keywords: Dementia risk; Loneliness; Psychosocial risk factors; Social isolation (search for similar items in EconPapers)
Date: 2020
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The Journals of Gerontology: Series B is currently edited by Psychological Sciences - S. Duke Han, PhD and Social Sciences - Jessica A Kelley, PhD, FGSA

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