Zonulin as a Biomarker in Mental Illness - Review

Miorita Melina Iordache () and Cristina Tocia
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Miorita Melina Iordache: „Ovidius†University of Constanta
Cristina Tocia: „Ovidius†University of Constanta

Ovidius University Annals, Economic Sciences Series, 2021, vol. XXI, issue 2, 325-331

Abstract: Mental health conditions are on the rise worldwide. This has determined an acceleration in the last two years in research focusing on mental health and brain-gut microbiome axis, highlighting the relevance of bidirectional communication. This systematic review aimed to gather evidence from studies of intestinal permeability biomarkers, in adults diagnosed with mental disorders, by following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). The selected articles provided evidence of intestinal permeability in adults diagnosed with neurocognitive impairment in Alzheimer's disease, schizophrenia, depression and suicide risk, bipolar affective disorder and alcohol consumption. Research shows that increased permeability and changes in the intestinal microbiota contribute to the pathogenesis of mental disorders. These findings support that this intestinal permeability biomarker had a role in mental disorders, but more information is needed for shedding light on this topic.

Keywords: biomarkers; mental disorders; Zonulin (search for similar items in EconPapers)
JEL-codes: I13 I18 (search for similar items in EconPapers)
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:ovi:oviste:v:xxi:y:2021:i:2:p:325-331

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