 Economic cost of strategic implementation approaches to increase uptake of digital therapeutics for substance use disorders in a large integrated health systemEdwin S Wong, Caitlin N Dorsey, Tara C Beatty, Jennifer F Bobb, Kelsey Stefanik-Guizlo, Dustin L Key, Arvind Ramaprasan, Abisola E Idu, John C Fortney, Jessica Mogk, Lorella Palazzo, Ryan M Caldeiro, Deborah King, Angela Garza McWethy and Joseph E Glass PLOS Digital Health, 2026, vol. 5, issue 1, 1-16 Abstract: Evidence-based digital therapeutics are a promising approach for the scale-up of substance use disorder (SUD) treatments. Despite demonstrated efficacy, utilization of digital therapeutics is low. Strategic implementation approaches have potential for increasing digital therapeutic use. Applicability to health systems depends, in part, on the economic costs. The objective of this study was to describe implementation and intervention costs of implementation strategies to increase uptake of an evidence-based digital treatment for SUD. We conducted an economic evaluation alongside a hybrid type III cluster-randomized trial within a large integrated health system. All clinics implemented a standard implementation (SI) strategy, and clinics were assigned using 2x2 factorial randomization to additionally receive practice facilitation (PF) and/or health coaching (HC). Implementation costs included the cost of time devoted to implementation activities and direct operating costs. Time devoted to implementation activities was ascertained through structured meeting logs and time use surveys. Operating costs were captured using project budget reports. Intervention costs included expenses for prescriptions and healthcare encounters related to the digital therapeutic, measured using electronic health record data. Univariate statistics were calculated for cost estimates with comparisons presented by trial arm, implementation activity, staff role and study month. Analyses were conducted from a health system perspective. Twenty-one primary care sites participated in the trial. Over the 50-month study period, the total cost of all implementation activities was $748,088. Implementation costs per clinic were highest in the SI + PF + HC arm ($48,029), followed by SI + HC ($36,544), SI + PF ($30,665) and SI alone ($24,774). Intervention costs were highest in the SI + PF + HC arm ($18,051), followed by SI + PF ($11,492), SI + HC ($967) and SI alone ($1,879). Findings from this study can guide health systems by informing the economic investment required to employ implementation strategies demonstrated to increase uptake of evidence-based practices for behavioral health conditions.Trial Registration: NCT05160233.Author summary: Digital therapeutics are an efficacious approach to treating substance use disorder, however, uptake is low. Strategic implementation approaches to facilitate uptake of evidence-based practices have the potential for increasing use of digital therapeutics. Of the limited number of studies examining economic aspects of implementation approaches, none have quantified costs of implementing practices for substance use disorder. To our knowledge, this is the first study to quantify the costs of implementing an evidence-based practice for substance use disorder in a real-world setting. Findings from this study can inform decisions to adopt evidence-based approaches for substance use disorder into routine clinical workflows. Date: 2026 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:plo:pdig00:0001145 DOI: 10.1371/journal.pdig.0001145 Access Statistics for this article More articles in PLOS Digital Health from Public Library of Science |
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