Family-Based versus Unrelated Case-Control Designs for Genetic Associations

Evangelos Evangelou, Thomas A Trikalinos, Georgia Salanti and John P A Ioannidis

PLOS Genetics, 2006, vol. 2, issue 8, 1-9

Abstract: The most simple and commonly used approach for genetic associations is the case-control study design of unrelated people. This design is susceptible to population stratification. This problem is obviated in family-based studies, but it is usually difficult to accumulate large enough samples of well-characterized families. We addressed empirically whether the two designs give similar estimates of association in 93 investigations where both unrelated case-control and family-based designs had been employed. Estimated odds ratios differed beyond chance between the two designs in only four instances (4%). The summary relative odds ratio (ROR) (the ratio of odds ratios obtained from unrelated case-control and family-based studies) was close to unity (0.96 [95% confidence interval, 0.91–1.01]). There was no heterogeneity in the ROR across studies (amount of heterogeneity beyond chance I2 = 0%). Differences on whether results were nominally statistically significant (p

Date: 2006
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.0020123 (text/html)
https://journals.plos.org/plosgenetics/article/fil ... 20123&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:0020123

DOI: 10.1371/journal.pgen.0020123

Access Statistics for this article

More articles in PLOS Genetics from Public Library of Science
Bibliographic data for series maintained by plosgenetics ().