PLOS Genetics

2005 - 2026

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Volume 22, issue 10, 2026

GPC: An expressive and tractable deep generative model for genetic variation data pp. 1-31

Prateek Anand, Anji Liu, Meihua Dang, Boyang Fu, Xinzhu Wei, Guy Van den Broeck and Sriram Sankararaman

Meta-analysis of over 8,000 individuals from Hawai‘i and Samoa for genetic associations to cardiometabolic phenotypes pp. 1-18

Bryan L Dinh, Xinran Wang, Xin Sheng, Peggy Wan, Amit Kumar Srivastava, Take Naseri, Satupa‘itea Viali, Lynne Wilkens, Loïc Le Marchand, Christopher Haiman, Daniel E Weeks, Charleston W K Chiang, Jenna C Carlson and The Samoan Obesity, Lifestyle and Genetic Adaptations (OLaGA) Study Group

Volume 22, issue 9, 2026

Assessing Hardy-Weinberg equilibrium in T2T-aligned 1000 genomes project pp. 1-24

Elika Garg, Jaffa Romain, Lei Sun and Andrew D Paterson

Univariate-guided sparse regression for Biobank-scale high-dimensional omics data pp. 1-18

Joshua Richland, Tuomo Kiiskinen, William Wang, Wenhui Sophia Lu, Balasubramanian Narasimhan, Trevor Hastie, Manuel Rivas and Robert Tibshirani

Volume 22, issue 7, 2026

Local ancestry inference with poorly-matched reference panels pp. 1-14

Sharon R Browning, Seth D Temple and Brian L Browning

A generalized test of genotype–phenotype causality in population-sampled nuclear families pp. 1-18

Yushi Tang and John D Storey

Multi-ancestry colocalization approaches pp. 1-21

Cathy Shen, Josée Dupuis and Qihuang Zhang

Volume 22, issue 6, 2026

The importance of nonsense errors: Estimating the rates and implications of ribosome drop-off during protein synthesis pp. 1-29

Alexander L Cope, Denizhan Pak and Michael A Gilchrist

Lysosome-related organelles employ divergent mechanisms to modulate cytosolic zinc homeostasis pp. 1-26

Chaoyi Xie, Yi Luo, Yawen Zheng, Bowen Liu, Shibo Song, Jie Wei, Anbing Shi and Yanling Yan

FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets pp. 1-34

Pravesh Parekh, Nadine Parker, Diliana Pecheva, Evgeniia Frei, Marc Vaudel, Diana M Smith, Alison Rigby, Piotr Jahołkowski, Ida Elken Sønderby, Viktoria Birkenæs, Nora Refsum Bakken, Chun Chieh Fan, Carolina Makowski, Jakub Kopal, Robert Loughnan, Donald J Hagler, Dennis van der Meer, Stefan Johansson, Pål Rasmus Njølstad, Terry L Jernigan, Wesley K Thompson, Oleksandr Frei, Alexey A Shadrin, Thomas E Nichols, Ole A Andreassen and Anders M Dale

The stoichiometry of minor-to-major pilins regulates the dynamic activity of the type IVa competence pilus in Vibrio cholerae pp. 1-17

Nicholas D Christman, Triana N Dalia, Jennifer L Chlebek and Ankur B Dalia

Volume 22, issue 5, 2026

Tissue-specific transfer learning improves functional variant and therapeutic target discoveries in breast and prostate cancer pp. 1-19

Qing Li, Dinghao Wang, Zilong Zhang, Deshan Perera, Zhishan Chen, Wanqing Wen, M Ethan MacDonald, Weijia Cai, Jun Yan, Xiao-Ou Shu, Wei Zheng, Xingyi Guo and Quan Long

MR2G: A novel framework for causal network inference using GWAS summary data pp. 1-21

Zhaotong Lin, Wei Pan and Haoran Xue

Volume 22, issue 4, 2026

The geometry of G × E: How scaling and endogenous treatment effects shape interaction direction pp. 1-24

Michal Sadowski, Andy W Dahl, Noah Zaitlen and Richard Border

Examining the association between fetal HLA-C, maternal KIR haplotypes and birth weight pp. 1-19

Caitlin Stephanie Decina, Nicole M Warrington, Robin N Beaumont, Beilei Bian, Caroline Brito Nunes, Geng Wang, William L Lowe, David Squire, Damjan Vukcevic, Stephen Leslie, Rachel M Freathy and David M Evans

Volume 22, issue 3, 2026

Polygenic risk scores and Parkinson’s disease in South Africa advancing ancestry informed disease prediction pp. 1-14

Kathryn Step, Carene Anne Alene Ndong Sima, Spencer Grant, Jonggeol Jeffrey Kim, Emily Waldo, Soraya Bardien, Ignacio F Mata and on behalf of the Global Parkinson’s Genetics Program (gp2)

Volume 22, issue 2, 2026

Hsp90 buffers behavioral variability by regulating Pdf transcription in clock neurons of Drosophila melanogaster pp. 1-21

Angelica Coculla, Carlina Feldmann, Maite Ogueta, Sina Mews, Roland Langrock and Ralf Stanewsky

Aneuploidy alleviates the cell proliferation defect caused by mutations affecting origin licensing in Saccharomyces cerevisiae pp. 1-25

Christophe de La Roche Saint-André

Volume 22, issue 1, 2026

Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations pp. 1-22

Benedict Adam Lenhart and Alan O Bergland

Joint modeling of effect sizes for two correlated traits: Characterizing trait properties to enhance polygenic risk prediction pp. 1-17

Chi Zhang, Geyu Zhou, Tianqi Chen and Hongyu Zhao

An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum pp. 1-33

Bhagaban Mallik, Shikha Kushwaha, Anjali Bisht, Harsha Mj, C Andrew Frank and Vimlesh Kumar

Volume 21, issue 12, 2025

Exploiting peptide chirality and transport to dissect the complex mechanism of action of host peptides on bacteria pp. 1-19

Siva Sankari, Markus F F Arnold, Vignesh M P Babu, Michael Deutsch and Graham C Walker

Getting to GRIPS with MR-Egger: Modelling directional pleiotropy independently of allele coding pp. 1-21

Frank Dudbridge, Bethany Voller, Ruby M Woodward, Katie L Saxby, Timothy M Frayling, Luke C Pilling and Jack Bowden

Volume 21, issue 11, 2025

Modeling the length distribution of gene conversion tracts in humans from the UK Biobank sequence data pp. 1-21

Nobuaki Masaki and Sharon R Browning

Volume 21, issue 10, 2025

Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies pp. 1-22

Kashyap Chhatbar, Adrian Bird and Guido Sanguinetti

Genome-wide analysis identifies susceptibility loci for heart failure and nonischemic cardiomyopathy subtype in the East Asian populations pp. 1-26

Yi Han, Yun Hong, Yan Gao, Jiapeng Lu, Bowang Chen, Lihua Zhang, Xiaofang Yan, Ying Sun, Liping Zhang, Jiangling Liu, Hao Dai, Libo Hou, Xi Li and Jing Li

Volume 21, issue 9, 2025

Ripply3 overdosage induces mid-face shortening through Tbx1 downregulation in Down syndrome models pp. 1-23

José Tomás Ahumada Saavedra, Claire Chevalier, Agnes Bloch Zupan and Yann Herault

Genome-wide association study provides novel insight into the genetic architecture of severe obesity pp. 1-27

Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E Justice, Geetha Chittoor, Hung-Hsin Chen, Rashedeh Roshani, Alyssa Scartozzi, Rachel R Dickerson, Roelof A J Smit, Michael H Preuss, Nathalie Chami, Benjamin S Hadad, Esteban J Parra, Miguel Cruz, Qin Hui, Peter W F Wilson, Yan V Sun, Xiaoyu Zhang, Gregorio V Linchangco, Sharon L R Kardia, Jessica D Faul, David R Weir, Lawrence F Bielak, Heather M Highland, Kristin L Young, Baiyu Qi, Yujie Wang, Myriam Fornage, Christopher Haiman, Iona Cheng, Ulrike Peters, Charles Kooperberg, Steven Buyske, Joseph B McCormick, Susan P Fisher-Hoch, Frida Lona-Durazo, Jesus Peralta, Jamie Gomez-Zamudio, Stephen S Rich, Kendra R Ferrier, Ethan M Lange, Christopher R Gignoux, Eimear E Kenny, Genevieve L Wojcik, Kelly Cho, Michael J Gaziano, Luc Djousse, Shuwei Liu, Dhananjay Vaidya, Renée de Mutsert, Navya S Josyula, Christopher R Bauer, Wei Zhao, Ryan W Walker, Jennifer A Smith, Leslie A Lange, Mariah C Meyer, Ching-Ti Liu, Lisa R Yanek, Miryoung Lee, Laura M Raffield, Ruth J F Loos, Penny Gordon-Larsen, Jennifer E Below, Kari E North and Mariaelisa Graff

Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants pp. 1-35

Ranjana Yadav, Guizhen Liu, Priyanshi Rana, Naga Jyothi Pullagurla, Danye Qiu, Henning J Jessen and Debabrata Laha

Variants in CALD1, ESRP1, and RBFOX1 are associated with orofacial cleft risk pp. 1-21

Jenna C Carlson, Xinyi Zhang, Zeynep Erdogan-Yildirim, Terri H Beaty, Azeez Butali, Carmen J Buxó, Lord JJ Gowans, Jacqueline T Hecht, Ross E Long, Lina Moreno, Jeffrey C Murray, Ieda M Orioli, Carmencita Padilla, George L Wehby, Eleanor Feingold, Elizabeth J Leslie-Clarkson, Seth M Weinberg, Mary L Marazita and John R Shaffer

Volume 21, issue 8, 2025

Detecting latent interaction effects when analyzing binary traits pp. 1-17

Ziang Zhang, Jerald F Lawless, Andrew D Paterson and Lei Sun

Understanding the alcohol harm paradox: A multivariable mendelian randomization approach pp. 1-15

Gemma Sawyer, Hannah Sallis, Marcus Munafò, Liam Mahedy and Jasmine Khouja

Gene dosage and protein valency impact phase separation and fungal cell fate pp. 1-33

Collin Ganser, Peiling He, Corey Frazer, Damian J Krysan and Richard J Bennett

Volume 21, issue 7, 2025

Genetic and environmental influences on the distributions of three chromosomal drive haplotypes in maize pp. 1-19

Meghan J Brady and R Kelly Dawe

Genomic organization, domain assortments, and nucleotide-binding domain diversity of NLR proteins in Sordariales fungi pp. 1-28

Lucas Bonometti, Florian Charriat, Noah Hensen, Silvia Miñana-Posada, Hanna Johannesson and Pierre Gladieux

Systematically identification of survival-associated eQTLs in a Japanese kidney cancer cohort pp. 1-28

Xiya Song, Han Jin, Xiangyu Li, Meng Yuan, Hong Yang, Yusuke Sato, Haruki Kume, Seishi Ogawa, Cheng Zhang and Adil Mardinoglu

Expectations for papers performing Mendelian randomization analyses pp. 1-4

Scott M Williams, Hua Tang, Gregory M Cooper, Anne O’Donnell-Luria, Santhosh Girirajan, Aimée M Dudley, Anne Goriely, Zoltán Kutalik, Xiaofeng Zhu, Giorgio Sirugo and Michael P Epstein

A novel expectation-maximization approach to infer general diploid selection from time-series genetic data pp. 1-38

Adam G Fine and Matthias Steinrücken

Volume 21, issue 6, 2025

Defining the high-translational readthrough stop codon context pp. 1-17

Daniela Smoljanow, Dennis Lebeda, Julia Hofhuis and Sven Thoms

Environmental data provide marginal benefit for predicting climate adaptation pp. 1-31

Forrest Li, Daniel J Gates, Edward S Buckler, Matthew B Hufford, Garrett M Janzen, Rubén Rellán-Álvarez, Fausto Rodríguez-Zapata, J Alberto Romero Navarro, Ruairidh J H Sawers, Samantha J Snodgrass, Kai Sonder, Martha C Willcox, Sarah J Hearne, Jeffrey Ross-Ibarra and Daniel E Runcie

Volume 21, issue 5, 2025

New composite phenotypes enhance chronic kidney disease classification and genetic associations pp. 1-15

Kim Ngan Tran, Heidi G Sutherland, Andrew J Mallett, Lyn R Griffiths and Rodney A Lea

Volume 21, issue 4, 2025

Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes pp. 1-33

Yuriko Harigaya, Nana Matoba, Brandon D Le, Jordan M Valone, Jason L Stein, Michael I Love and William Valdar

Probing the limits of cis-acting gene regulation using a model of allelic imbalance quantitative trait loci pp. 1-19

Cathal Seoighe, Seán Connaire and Mehak Chopra

Volume 21, issue 3, 2025

RatXcan: A framework for cross-species integration of genome-wide association and gene expression data pp. 1-18

Natasha Santhanam, Sandra Sanchez-Roige, Sabrina Mi, Yanyu Liang, Apurva S Chitre, Daniel Munro, Denghui Chen, Jianjun Gao, Angel Garcia-Martinez, Anthony M George, Alexander F Gileta, Wenyan Han, Katie Holl, Alesa Hughson, Christopher P King, Alexander C Lamparelli, Connor D Martin, Festus Nyasimi, Celine L St. Pierre, Sarah Sumner, Jordan Tripi, Tengfei Wang, Hao Chen, Shelly Flagel, Keita Ishiwari, Paul Meyer, Oksana Polesskaya, Laura Saba, Leah C Solberg Woods, Abraham A Palmer and Hae Kyung Im

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease pp. 1-16

Nicholas R Ray, Joseph Bradley, Elanur Yilmaz, Caghan Kizil, Jiji T Kurup, Eden R Martin, Hans-Ulrich Klein, Brian W Kunkle, David A Bennett, Philip L De Jager, Alzheimer’s Disease Genetics Consortium, Gary W Beecham, Carlos Cruchaga and Christiane Reitz

Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes pp. 1-33

Amit K Srivastava, Julius Juodakis, Pol Sole-Navais, Jing Chen, Jonas Bacelis, Kari Teramo, Mikko Hallman, Pal R Njølstad, David M Evans, Bo Jacobsson, Louis J Muglia and Ge Zhang

Volume 21, issue 2, 2025

Two transmembrane transcriptional regulators coordinate to activate chitin-induced natural transformation in Vibrio cholerae pp. 1-20

Allison C Hullinger, Virginia E Green, Catherine A Klancher, Triana N Dalia and Ankur B Dalia

Volume 21, issue 1, 2025

ADELLE: A global testing method for trans-eQTL mapping pp. 1-22

Takintayo Akinbiyi, Mary Sara McPeek and Mark Abney

Refining fine-mapping: Effect sizes and regional heritability pp. 1-21

Christian Benner, Anubha Mahajan and Matti Pirinen

metaGE: Investigating genotype x environment interactions through GWAS meta-analysis pp. 1-26

Annaïg De Walsche, Alexis Vergne, Renaud Rincent, Fabrice Roux, Stéphane Nicolas, Claude Welcker, Sofiane Mezmouk, Alain Charcosset and Tristan Mary-Huard

Estimating evolutionary and demographic parameters via ARG-derived IBD pp. 1-16

Zhendong Huang, Jerome Kelleher, Yao-ban Chan and David Balding