PLOS Genetics

2005 - 2022

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Volume 10, issue 12, 2014

Genome Wide Meta-analysis Highlights the Role of Genetic Variation in RARRES2 in the Regulation of Circulating Serum Chemerin pp. 1-11

Anke Tönjes, Markus Scholz, Jana Breitfeld, Carola Marzi, Harald Grallert, Arnd Gross, Claes Ladenvall, Dorit Schleinitz, Kerstin Krause, Holger Kirsten, Esa Laurila, Jennifer Kriebel, Barbara Thorand, Wolfgang Rathmann, Leif Groop, Inga Prokopenko, Bo Isomaa, Frank Beutner, Jürgen Kratzsch, Joachim Thiery, Mathias Fasshauer, Nora Klöting, Christian Gieger, Matthias Blüher, Michael Stumvoll and Peter Kovacs

Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease pp. 1-10

Andrea Ganna, Samira Salihovic, Johan Sundström, Corey D Broeckling, Åsa K Hedman, Patrik K E Magnusson, Nancy L Pedersen, Anders Larsson, Agneta Siegbahn, Mihkel Zilmer, Jessica Prenni, Johan Ärnlöv, Lars Lind, Tove Fall and Erik Ingelsson

Identification of Rare Causal Variants in Sequence-Based Studies: Methods and Applications to VPS13B, a Gene Involved in Cohen Syndrome and Autism pp. 1-17

Iuliana Ionita-Laza, Marinela Capanu, Silvia De Rubeis, Kenneth McCallum and Joseph D Buxbaum

Echoes of the Past: Hereditarianism and A Troublesome Inheritance pp. 1-3

Marcus Feldman

Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers pp. 1-6

Amy E Taylor, Richard W Morris, Meg E Fluharty, Johan H Bjorngaard, Bjørn Olav Åsvold, Maiken E Gabrielsen, Archie Campbell, Riccardo Marioni, Meena Kumari, Jenni Hällfors, Satu Männistö, Pedro Marques-Vidal, Marika Kaakinen, Alana Cavadino, Iris Postmus, Lise Lotte N Husemoen, Tea Skaaby, Tarunveer S Ahluwalia, Jorien L Treur, Gonneke Willemsen, Caroline Dale, S Goya Wannamethee, Jari Lahti, Aarno Palotie, Katri Räikkönen, Aliaksei Kisialiou, Alex McConnachie, Sandosh Padmanabhan, Andrew Wong, Christine Dalgård, Lavinia Paternoster, Yoav Ben-Shlomo, Jessica Tyrrell, John Horwood, David M Fergusson, Martin A Kennedy, Tim Frayling, Ellen A Nohr, Lene Christiansen, Kirsten Ohm Kyvik, Diana Kuh, Graham Watt, Johan Eriksson, Peter H Whincup, Jacqueline M Vink, Dorret I Boomsma, George Davey Smith, Debbie Lawlor, Allan Linneberg, Ian Ford, J Wouter Jukema, Christine Power, Elina Hyppönen, Marjo-Riitta Jarvelin, Martin Preisig, Katja Borodulin, Jaakko Kaprio, Mika Kivimaki, Blair H Smith, Caroline Hayward, Pål R Romundstad, Thorkild I A Sørensen, Marcus R Munafò and Naveed Sattar

Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation pp. 1-19

Jacob C Ulirsch, Jessica N Lacy, Xiuli An, Narla Mohandas, Tarjei S Mikkelsen and Vijay G Sankaran

Mediation Analysis Demonstrates That Trans-eQTLs Are Often Explained by Cis-Mediation: A Genome-Wide Analysis among 1,800 South Asians pp. 1-13

Brandon L Pierce, Lin Tong, Lin S Chen, Ronald Rahaman, Maria Argos, Farzana Jasmine, Shantanu Roy, Rachelle Paul-Brutus, Harm-Jan Westra, Lude Franke, Tonu Esko, Rakibuz Zaman, Tariqul Islam, Mahfuzar Rahman, John A Baron, Muhammad G Kibriya and Habibul Ahsan

Volume 10, issue 11, 2014

Glutamate Receptor Gene GRIN2A, Coffee, and Parkinson Disease pp. 1-2

Taye H Hamza, Erin M Hill-Burns, William K Scott, Jeffrey M Vance, Stewart A Factor, Cyrus P Zabetian and Haydeh Payami

ARTIST: High-Resolution Genome-Wide Assessment of Fitness Using Transposon-Insertion Sequencing pp. 1-15

Justin R Pritchard, Michael C Chao, Sören Abel, Brigid M Davis, Catherine Baranowski, Yanjia J Zhang, Eric J Rubin and Matthew K Waldor

Approximation to the Distribution of Fitness Effects across Functional Categories in Human Segregating Polymorphisms pp. 1-14

Fernando Racimo and Joshua G Schraiber

GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation pp. 1-14

Dongjun Chung, Can Yang, Cong Li, Joel Gelernter and Hongyu Zhao

Regularized Machine Learning in the Genetic Prediction of Complex Traits pp. 1-9

Sebastian Okser, Tapio Pahikkala, Antti Airola, Tapio Salakoski, Samuli Ripatti and Tero Aittokallio

Lack of Replication of the GRIN2A-by-Coffee Interaction in Parkinson Disease pp. 1-9

Ismaïl Ahmed, Pei-Chen Lee, Christina M Lill, Susan Searles Nielsen, Fanny Artaud, Lisa G Gallagher, Marie-Anne Loriot, Claire Mulot, Magali Nacfer, Tian Liu, Joanna M Biernacka, Sebastian Armasu, Kari Anderson, Federico M Farin, Christina Funch Lassen, Johnni Hansen, Jørgen H Olsen, Lars Bertram, Demetrius M Maraganore, Harvey Checkoway, Beate Ritz and Alexis Elbaz

Genetic Analysis of a Novel Tubulin Mutation That Redirects Synaptic Vesicle Targeting and Causes Neurite Degeneration in C. elegans pp. 1-16

Jiun-Min Hsu, Chun-Hao Chen, Yen-Chih Chen, Kent L McDonald, Mark Gurling, Albert Lee, Gian Garriga and Chun-Liang Pan

Volume 10, issue 10, 2014

The Proteomic Landscape of the Suprachiasmatic Nucleus Clock Reveals Large-Scale Coordination of Key Biological Processes pp. 1-15

Cheng-Kang Chiang, Neel Mehta, Abhilasha Patel, Peng Zhang, Zhibin Ning, Janice Mayne, Warren Y L Sun, Hai-Ying M Cheng and Daniel Figeys

Unifying Genetic Canalization, Genetic Constraint, and Genotype-by-Environment Interaction: QTL by Genomic Background by Environment Interaction of Flowering Time in Boechera stricta pp. 1-17

Cheng-Ruei Lee, Jill T Anderson and Thomas Mitchell-Olds

Genetic Modifiers of Neurofibromatosis Type 1-Associated Café-au-Lait Macule Count Identified Using Multi-platform Analysis pp. 1-12

Alexander Pemov, Heejong Sung, Paula L Hyland, Jennifer L Sloan, Sarah L Ruppert, Andrea M Baldwin, Joseph F Boland, Sara E Bass, Hyo Jung Lee, Kristine M Jones, Xijun Zhang, Comparative Sequencing Program Nisc, James C Mullikin, Brigitte C Widemann, Alexander F Wilson and Douglas R Stewart

Payoffs, Not Tradeoffs, in the Adaptation of a Virus to Ostensibly Conflicting Selective Pressures pp. 1-12

Lindsey W McGee, Erick W Aitchison, S Brian Caudle, Anneliese J Morrison, Lianqing Zheng, Wei Yang and Darin R Rokyta

Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4) pp. 1-12

Felix M Key, Benjamin Peter, Megan Y Dennis, Emilia Huerta-Sánchez, Wei Tang, Ludmila Prokunina-Olsson, Rasmus Nielsen and Aida M Andrés

Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies pp. 1-16

Gleb Kichaev, Wen-Yun Yang, Sara Lindstrom, Farhad Hormozdiari, Eleazar Eskin, Alkes L Price, Peter Kraft and Bogdan Pasaniuc

Mmp1 Processing of the PDF Neuropeptide Regulates Circadian Structural Plasticity of Pacemaker Neurons pp. 1-14

Ana Depetris-Chauvin, Ágata Fernández-Gamba, E Axel Gorostiza, Anastasia Herrero, Eduardo M Castaño and M Fernanda Ceriani

Volume 10, issue 9, 2014

The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function pp. 1-12

Ya-Juan Wang, Bamidele O Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yun Ju Sung, the COGENT BP Consortium, Robert C Elston, Scott M Williams, Richard S Cooper, Ting-Wei Mu and Xiaofeng Zhu

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments pp. 1-15

Claire S Leblond, Caroline Nava, Anne Polge, Julie Gauthier, Guillaume Huguet, Serge Lumbroso, Fabienne Giuliano, Coline Stordeur, Christel Depienne, Kevin Mouzat, Dalila Pinto, Jennifer Howe, Nathalie Lemière, Christelle M Durand, Jessica Guibert, Elodie Ey, Roberto Toro, Hugo Peyre, Alexandre Mathieu, Frédérique Amsellem, Maria Rastam, I Carina Gillberg, Gudrun A Rappold, Richard Holt, Anthony P Monaco, Elena Maestrini, Pilar Galan, Delphine Heron, Aurélia Jacquette, Alexandra Afenjar, Agnès Rastetter, Alexis Brice, Françoise Devillard, Brigitte Assouline, Fanny Laffargue, James Lespinasse, Jean Chiesa, François Rivier, Dominique Bonneau, Beatrice Regnault, Diana Zelenika, Marc Delepine, Mark Lathrop, Damien Sanlaville, Caroline Schluth-Bolard, Patrick Edery, Laurence Perrin, Anne Claude Tabet, Michael J Schmeisser, Tobias M Boeckers, Mary Coleman, Daisuke Sato, Peter Szatmari, Stephen W Scherer, Guy A Rouleau, Catalina Betancur, Marion Leboyer, Christopher Gillberg, Richard Delorme and Thomas Bourgeron

Volume 10, issue 8, 2014

A Model-Based Approach for Identifying Signatures of Ancient Balancing Selection in Genetic Data pp. 1-20

Michael DeGiorgio, Kirk E Lohmueller and Rasmus Nielsen

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes pp. 1-14

Maggie C Y Ng, Daniel Shriner, Brian H Chen, Jiang Li, Wei-Min Chen, Xiuqing Guo, Jiankang Liu, Suzette J Bielinski, Lisa R Yanek, Michael A Nalls, Mary E Comeau, Laura J Rasmussen-Torvik, Richard A Jensen, Daniel S Evans, Yan V Sun, Ping An, Sanjay R Patel, Yingchang Lu, Jirong Long, Loren L Armstrong, Lynne Wagenknecht, Lingyao Yang, Beverly M Snively, Nicholette D Palmer, Poorva Mudgal, Carl D Langefeld, Keith L Keene, Barry I Freedman, Josyf C Mychaleckyj, Uma Nayak, Leslie J Raffel, Mark O Goodarzi, Ida Chen Y-D, Herman A Taylor, Adolfo Correa, Mario Sims, David Couper, James S Pankow, Eric Boerwinkle, Adebowale Adeyemo, Ayo Doumatey, Guanjie Chen, Rasika A Mathias, Dhananjay Vaidya, Andrew B Singleton, Alan B Zonderman, Robert P Igo, John R Sedor, the FIND Consortium, Edmond K Kabagambe, David S Siscovick, Barbara McKnight, Kenneth Rice, Yongmei Liu, Wen-Chi Hsueh, Wei Zhao, Lawrence F Bielak, Aldi Kraja, Michael A Province, Erwin P Bottinger, Omri Gottesman, Qiuyin Cai, Wei Zheng, William J Blot, William L Lowe, Jennifer A Pacheco, Dana C Crawford, the eMERGE Consortium, the DIAGRAM Consortium, Elin Grundberg, the MuTHER Consortium, Stephen S Rich, M Geoffrey Hayes, Xiao-Ou Shu, Ruth J F Loos, Ingrid B Borecki, Patricia A Peyser, Steven R Cummings, Bruce M Psaty, Myriam Fornage, Sudha K Iyengar, Michele K Evans, Diane M Becker, W H Linda Kao, James G Wilson, Jerome I Rotter, Michèle M Sale, Simin Liu, Charles N Rotimi, Donald W Bowden and for the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium

A Population Genetic Signal of Polygenic Adaptation pp. 1-25

Jeremy J Berg and Graham Coop

Volume 10, issue 7, 2014

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease pp. 1-14

Ville-Petteri Mäkinen, Mete Civelek, Qingying Meng, Bin Zhang, Jun Zhu, Candace Levian, Tianxiao Huan, Ayellet V Segrè, Sujoy Ghosh, Juan Vivar, Majid Nikpay, Alexandre F R Stewart, Christopher P Nelson, Christina Willenborg, Jeanette Erdmann, Stefan Blakenberg, Christopher J O'Donnell, Winfried März, Reijo Laaksonen, Stephen E Epstein, Sekar Kathiresan, Svati H Shah, Stanley L Hazen, Muredach P Reilly, the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium, Aldons J Lusis, Nilesh J Samani, Heribert Schunkert, Thomas Quertermous, Ruth McPherson, Xia Yang and Themistocles L Assimes

Comparison of Methods to Account for Relatedness in Genome-Wide Association Studies with Family-Based Data pp. 1-20

Jakris Eu-ahsunthornwattana, E Nancy Miller, Michaela Fakiola, Wellcome Trust Case Control Consortium 2, Selma M B Jeronimo, Jenefer M Blackwell and Heather J Cordell

A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach pp. 1-11

Matthew Traylor, Kari-Matti Mäkelä, Laura L Kilarski, Elizabeth G Holliday, William J Devan, Mike A Nalls, Kerri L Wiggins, Wei Zhao, Yu-Ching Cheng, Sefanja Achterberg, Rainer Malik, Cathie Sudlow, Steve Bevan, Emma Raitoharju, METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (wtccc2), Niku Oksala, Vincent Thijs, Robin Lemmens, Arne Lindgren, Agnieszka Slowik, Jane M Maguire, Matthew Walters, Ale Algra, Pankaj Sharma, John R Attia, Giorgio B Boncoraglio, Peter M Rothwell, Paul I W de Bakker, Joshua C Bis, Danish Saleheen, Steven J Kittner, Braxton D Mitchell, Jonathan Rosand, James F Meschia, Christopher Levi, Martin Dichgans, Terho Lehtimäki, Cathryn M Lewis and Hugh S Markus

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin pp. 1-11

Jennifer L Bolton, Caroline Hayward, Nese Direk, John G Lewis, Geoffrey L Hammond, Lesley A Hill, Anna Anderson, Jennifer Huffman, James F Wilson, Harry Campbell, Igor Rudan, Alan Wright, Nicholas Hastie, Sarah H Wild, Fleur P Velders, Albert Hofman, Andre G Uitterlinden, Jari Lahti, Katri Räikkönen, Eero Kajantie, Elisabeth Widen, Aarno Palotie, Johan G Eriksson, Marika Kaakinen, Marjo-Riitta Järvelin, Nicholas J Timpson, George Davey Smith, Susan M Ring, Martin Evans, Beate St Pourcain, Toshiko Tanaka, Yuri Milaneschi, Stefania Bandinelli, Luigi Ferrucci, Pim van der Harst, Judith G M Rosmalen, Stephen J L Bakker, Niek Verweij, Robin P F Dullaart, Anubha Mahajan, Cecilia M Lindgren, Andrew Morris, Lars Lind, Erik Ingelsson, Laura N Anderson, Craig E Pennell, Stephen J Lye, Stephen G Matthews, Joel Eriksson, Dan Mellstrom, Claes Ohlsson, Jackie F Price, Mark W J Strachan, Rebecca M Reynolds, Henning Tiemeier, Brian R Walker and on behalf of the CORtisol NETwork (CORNET) Consortium

Cuba: Exploring the History of Admixture and the Genetic Basis of Pigmentation Using Autosomal and Uniparental Markers pp. 1-13

Beatriz Marcheco-Teruel, Esteban J Parra, Evelyn Fuentes-Smith, Antonio Salas, Henriette N Buttenschøn, Ditte Demontis, María Torres-Español, Lilia C Marín-Padrón, Enrique J Gómez-Cabezas, Vanesa Álvarez-Iglesias, Ana Mosquera-Miguel, Antonio Martínez-Fuentes, Ángel Carracedo, Anders D Børglum and Ole Mors

Volume 10, issue 6, 2014

Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment pp. 1-18

John P Kemp, Carolina Medina-Gomez, Karol Estrada, Beate St Pourcain, Denise H M Heppe, Nicole M Warrington, Ling Oei, Susan M Ring, Claudia J Kruithof, Nicholas J Timpson, Lisa E Wolber, Sjur Reppe, Kaare Gautvik, Elin Grundberg, Bing Ge, Bram van der Eerden, Jeroen van de Peppel, Matthew A Hibbs, Cheryl L Ackert-Bicknell, Kwangbom Choi, Daniel L Koller, Michael J Econs, Frances M K Williams, Tatiana Foroud, M Carola Zillikens, Claes Ohlsson, Albert Hofman, André G Uitterlinden, George Davey Smith, Vincent W V Jaddoe, Jonathan H Tobias, Fernando Rivadeneira and Martin Evans

Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study pp. 1-10

Tibor V Varga, Emily Sonestedt, Dmitry Shungin, Robert W Koivula, Göran Hallmans, Stefan A Escher, Inês Barroso, Peter Nilsson, Olle Melander, Marju Orho-Melander, Frida Renström and Paul W Franks

Volume 10, issue 5, 2014

Heterogeneity in the Frequency and Characteristics of Homologous Recombination in Pneumococcal Evolution pp. 1-15

Rafal Mostowy, Nicholas J Croucher, William P Hanage, Simon R Harris, Stephen Bentley and Christophe Fraser

Insights into the Genetic Structure and Diversity of 38 South Asian Indians from Deep Whole-Genome Sequencing pp. 1-15

Lai-Ping Wong, Jason Kuan-Han Lai, Woei-Yuh Saw, Rick Twee-Hee Ong, Anthony Youzhi Cheng, Nisha Esakimuthu Pillai, Xuanyao Liu, Wenting Xu, Peng Chen, Jia-Nee Foo, Linda Wei-Lin Tan, Seok-Hwee Koo, Richie Soong, Markus Rene Wenk, Wei-Yen Lim, Chiea-Chuen Khor, Peter Little, Kee-Seng Chia and Yik-Ying Teo

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics pp. 1-15

Claudia Giambartolomei, Damjan Vukcevic, Eric E Schadt, Lude Franke, Aroon D Hingorani, Chris Wallace and Vincent Plagnol

Genome-Wide Inference of Ancestral Recombination Graphs pp. 1-27

Matthew D Rasmussen, Melissa J Hubisz, Ilan Gronau and Adam Siepel

Volume 10, issue 4, 2014

Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples pp. 1-10

Peter M Visscher, Gibran Hemani, Anna A E Vinkhuyzen, Guo-Bo Chen, Sang Hong Lee, Naomi R Wray, Michael E Goddard and Jian Yang

Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer pp. 1-9

Jane C Figueiredo, Li Hsu, Carolyn M Hutter, Yi Lin, Peter T Campbell, John A Baron, Sonja I Berndt, Shuo Jiao, Graham Casey, Barbara Fortini, Andrew T Chan, Michelle Cotterchio, Mathieu Lemire, Steven Gallinger, Tabitha A Harrison, Loic Le Marchand, Polly A Newcomb, Martha L Slattery, Bette J Caan, Christopher S Carlson, Brent W Zanke, Stephanie A Rosse, Hermann Brenner, Edward L Giovannucci, Kana Wu, Jenny Chang-Claude, Stephen J Chanock, Keith R Curtis, David Duggan, Jian Gong, Robert W Haile, Richard B Hayes, Michael Hoffmeister, John L Hopper, Mark A Jenkins, Laurence N Kolonel, Conghui Qu, Anja Rudolph, Robert E Schoen, Fredrick R Schumacher, Daniela Seminara, Deanna L Stelling, Stephen N Thibodeau, Mark Thornquist, Greg S Warnick, Brian E Henderson, Cornelia M Ulrich, W James Gauderman, John D Potter, Emily White, Ulrike Peters, On Behalf Of Ccfr and and GECCO

A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness pp. 1-21

Jared O'Connell, Deepti Gurdasani, Olivier Delaneau, Nicola Pirastu, Sheila Ulivi, Massimiliano Cocca, Michela Traglia, Jie Huang, Jennifer E Huffman, Igor Rudan, Ruth McQuillan, Ross M Fraser, Harry Campbell, Ozren Polasek, Gershim Asiki, Kenneth Ekoru, Caroline Hayward, Alan F Wright, Veronique Vitart, Pau Navarro, Jean-Francois Zagury, James F Wilson, Daniela Toniolo, Paolo Gasparini, Nicole Soranzo, Manjinder S Sandhu and Jonathan Marchini

A Central Role for GRB10 in Regulation of Islet Function in Man pp. 1-13

Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad B, S Albert Salehi, Peter Almgren, Peter Osmark, Nabila Bouatia-Naji, Nils Wierup, Tove Fall, Alena Stančáková, Adam Barker, Vasiliki Lagou, Clive Osmond, Weijia Xie, Jari Lahti, Anne U Jackson, Yu-Ching Cheng, Jie Liu, Jeffrey R O'Connell, Paul A Blomstedt, Joao Fadista, Sami Alkayyali, Tasnim Dayeh, Emma Ahlqvist, Jalal Taneera, Cecile Lecoeur, Ashish Kumar, Ola Hansson, Karin Hansson, Benjamin F Voight, Hyun Min Kang, Claire Levy-Marchal, Vincent Vatin, Aarno Palotie, Ann-Christine Syvänen, Andrea Mari, Michael N Weedon, Ruth J F Loos, Ken K Ong, Peter Nilsson, Bo Isomaa, Tiinamaija Tuomi, Nicholas J Wareham, Michael Stumvoll, Elisabeth Widen, Timo A Lakka, Claudia Langenberg, Anke Tönjes, Rainer Rauramaa, Johanna Kuusisto, Timothy M Frayling, Philippe Froguel, Mark Walker, Johan G Eriksson, Charlotte Ling, Peter Kovacs, Erik Ingelsson, Mark I McCarthy, Alan R Shuldiner, Kristi D Silver, Markku Laakso, Leif Groop and Valeriya Lyssenko

Volume 10, issue 3, 2014

Modeling 3D Facial Shape from DNA pp. 1-14

Peter Claes, Denise K Liberton, Katleen Daniels, Kerri Matthes Rosana, Ellen E Quillen, Laurel N Pearson, Brian McEvoy, Marc Bauchet, Arslan A Zaidi, Wei Yao, Hua Tang, Gregory S Barsh, Devin M Absher, David A Puts, Jorge Rocha, Sandra Beleza, Rinaldo W Pereira, Gareth Baynam, Paul Suetens, Dirk Vandermeulen, Jennifer K Wagner, James S Boster and Mark D Shriver

Worldwide Patterns of Ancestry, Divergence, and Admixture in Domesticated Cattle pp. 1-14

Jared E Decker, Stephanie D McKay, Megan M Rolf, JaeWoo Kim, Antonio Molina Alcalá, Tad S Sonstegard, Olivier Hanotte, Anders Götherström, Christopher M Seabury, Lisa Praharani, Masroor Ellahi Babar, Luciana Correia de Almeida Regitano, Mehmet Ali Yildiz, Michael P Heaton, Wan-Sheng Liu, Chu-Zhao Lei, James M Reecy, Muhammad Saif-Ur-Rehman, Robert D Schnabel and Jeremy F Taylor

Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke pp. 1-13

Stephen R Williams, Qiong Yang, Fang Chen, Xuan Liu, Keith L Keene, Paul Jacques, Wei-Min Chen, Galit Weinstein, Fang-Chi Hsu, Alexa Beiser, Liewei Wang, Ebony Bookman, Kimberly F Doheny, Philip A Wolf, Michelle Zilka, Jacob Selhub, Sarah Nelson, Stephanie M Gogarten, Bradford B Worrall, Sudha Seshadri, Michèle M Sale, the Genomics and Randomized Trials Network and the Framingham Heart Study

Genetic Diversity in the Interference Selection Limit pp. 1-1

Benjamin H Good, Aleksandra M Walczak, Richard A Neher and Michael M Desai

ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma pp. 1-8

Monisha E Nongpiur, Chiea Chuen Khor, Hongyan Jia, Belinda K Cornes, Li-Jia Chen, Chunyan Qiao, K Saidas Nair, Ching-Yu Cheng, Liang Xu, Ronnie George, Do Tan, Khaled Abu-Amero, Shamira A Perera, Mineo Ozaki, Takanori Mizoguchi, Yasuo Kurimoto, Sancy Low, Liza-Sharmini A Tajudin, Ching-Lin Ho, Clement C Y Tham, Ileana Soto, Paul T K Chew, Hon-Tym Wong, Balekudaru Shantha, Masako Kuroda, Essam A Osman, Guangxian Tang, Sujie Fan, Hailin Meng, Hua Wang, Bo Feng, Victor H K Yong, Serena M L Ting, Yang Li, Ya-Xing Wang, Zheng Li, Raghavan Lavanya, Ren-Yi Wu, Ying-Feng Zheng, Daniel H Su, Seng-Chee Loon, R Rand Allingham, Michael A Hauser, Nagaswamy Soumittra, Vedam L Ramprasad, Naushin Waseem, Azhany Yaakub, Kee-Seng Chia, Govindasamy Kumaramanickavel, Tina T Wong, Alicia C How, Tran Nguyen Bich Chau, Cameron P Simmons, Jin-Xin Bei, Yi-Xin Zeng, Shomi S Bhattacharya, Mingzhi Zhang, Donald T Tan, Yik-Ying Teo, Saleh A Al-Obeidan, Do Nhu Hon, E-Shyong Tai, Seang-Mei Saw, Paul J Foster, Lingam Vijaya, Jost B Jonas, Tien-Yin Wong, Simon W M John, Chi-Pui Pang, Eranga N Vithana, Ningli Wang and Tin Aung

Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes pp. 1-11

Sheli L Ostrow, Ruth Barshir, James DeGregori, Esti Yeger-Lotem and Ruth Hershberg

A Multi-Trait, Meta-analysis for Detecting Pleiotropic Polymorphisms for Stature, Fatness and Reproduction in Beef Cattle pp. 1-23

Sunduimijid Bolormaa, Jennie E Pryce, Antonio Reverter, Yuandan Zhang, William Barendse, Kathryn Kemper, Bruce Tier, Keith Savin, Ben J Hayes and Michael E Goddard

Volume 10, issue 2, 2014

Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses pp. 1-7

Kristina Ibáñez, César Boullosa, Rafael Tabarés-Seisdedos, Anaïs Baudot and Alfonso Valencia

Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning pp. 1-15

Gad Abraham, Jason A Tye-Din, Oneil G Bhalala, Adam Kowalczyk, Justin Zobel and Michael Inouye

Negative Feedback and Transcriptional Overshooting in a Regulatory Network for Horizontal Gene Transfer pp. 1-15

Raul Fernandez-Lopez, Irene del Campo, Carlos Revilla, Ana Cuevas and Fernando de la Cruz

miR-100 Induces Epithelial-Mesenchymal Transition but Suppresses Tumorigenesis, Migration and Invasion pp. 1-14

Dahu Chen, Yutong Sun, Yuan Yuan, Zhenbo Han, Peijing Zhang, Jinsong Zhang, M James You, Julie Teruya-Feldstein, Min Wang, Sumeet Gupta, Mien-Chie Hung, Han Liang and Li Ma

Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation pp. 1-12

Taru Tukiainen, Matti Pirinen, Antti-Pekka Sarin, Claes Ladenvall, Johannes Kettunen, Terho Lehtimäki, Marja-Liisa Lokki, Markus Perola, Juha Sinisalo, Efthymia Vlachopoulou, Johan G Eriksson, Leif Groop, Antti Jula, Marjo-Riitta Järvelin, Olli T Raitakari, Veikko Salomaa and Samuli Ripatti

Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective pp. 1-17

Matthieu Foll, Yu-Ping Poh, Nicholas Renzette, Anna Ferrer-Admetlla, Claudia Bank, Hyunjin Shim, Anna-Sapfo Malaspinas, Gregory Ewing, Ping Liu, Daniel Wegmann, Daniel R Caffrey, Konstantin B Zeldovich, Daniel N Bolon, Jennifer P Wang, Timothy F Kowalik, Celia A Schiffer, Robert W Finberg and Jeffrey D Jensen

Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease pp. 1-13

Marco Medici, Eleonora Porcu, Giorgio Pistis, Alexander Teumer, Suzanne J Brown, Richard A Jensen, Rajesh Rawal, Greet L Roef, Theo S Plantinga, Sita H Vermeulen, Jari Lahti, Matthew J Simmonds, Lise Lotte N Husemoen, Rachel M Freathy, Beverley M Shields, Diana Pietzner, Rebecca Nagy, Linda Broer, Layal Chaker, Tim I M Korevaar, Maria Grazia Plia, Cinzia Sala, Uwe Völker, J Brent Richards, Fred C Sweep, Christian Gieger, Tanguy Corre, Eero Kajantie, Betina Thuesen, Youri E Taes, W Edward Visser, Andrew T Hattersley, Jürgen Kratzsch, Alexander Hamilton, Wei Li, Georg Homuth, Monia Lobina, Stefano Mariotti, Nicole Soranzo, Massimiliano Cocca, Matthias Nauck, Christin Spielhagen, Alec Ross, Alice Arnold, Martijn van de Bunt, Sandya Liyanarachchi, Margit Heier, Hans Jörgen Grabe, Corrado Masciullo, Tessel E Galesloot, Ee M Lim, Eva Reischl, Peter J Leedman, Sandra Lai, Alessandro Delitala, Alexandra P Bremner, David I W Philips, John P Beilby, Antonella Mulas, Matteo Vocale, Goncalo Abecasis, Tom Forsen, Alan James, Elisabeth Widen, Jennie Hui, Holger Prokisch, Ernst E Rietzschel, Aarno Palotie, Peter Feddema, Stephen J Fletcher, Katharina Schramm, Jerome I Rotter, Alexander Kluttig, Dörte Radke, Michela Traglia, Gabriela L Surdulescu, Huiling He, Jayne A Franklyn, Daniel Tiller, Bijay Vaidya, Tim de Meyer, Torben Jørgensen, Johan G Eriksson, Peter C O'Leary, Eric Wichmann, Ad R Hermus, Bruce M Psaty, Till Ittermann, Albert Hofman, Emanuele Bosi, David Schlessinger, Henri Wallaschofski, Nicola Pirastu, Yurii S Aulchenko, Albert de la Chapelle, Romana T Netea-Maier, Stephen C L Gough, Henriette Meyer zu Schwabedissen, Timothy M Frayling, Jean-Marc Kaufman, Allan Linneberg, Katri Räikkönen, Johannes W A Smit, Lambertus A Kiemeney, Fernando Rivadeneira, André G Uitterlinden, John P Walsh, Christa Meisinger, Martin den Heijer, Theo J Visser, Timothy D Spector, Scott G Wilson, Henry Völzke, Anne Cappola, Daniela Toniolo, Serena Sanna, Silvia Naitza and Robin P Peeters

Fifteen Years Later: Hard and Soft Selection Sweeps Confirm a Large Population Number for HIV In Vivo pp. 1-3

Igor M Rouzine, John M Coffin and Leor S Weinberger

Volume 10, issue 1, 2014

Functional Divergence and Evolutionary Turnover in Mammalian Phosphoproteomes pp. 1-13

Luca Freschi, Mazid Osseni and Christian R Landry

Crossover Patterning by the Beam-Film Model: Analysis and Implications pp. 1-24

Liangran Zhang, Zhangyi Liang, John Hutchinson and Nancy Kleckner

Multi-tissue Analysis of Co-expression Networks by Higher-Order Generalized Singular Value Decomposition Identifies Functionally Coherent Transcriptional Modules pp. 1-16

Xiaolin Xiao, Aida Moreno-Moral, Maxime Rotival, Leonardo Bottolo and Enrico Petretto

Meta-Analysis Identifies Gene-by-Environment Interactions as Demonstrated in a Study of 4,965 Mice pp. 1-16

Eun Yong Kang, Buhm Han, Nicholas Furlotte, Jong Wha J Joo, Diana Shih, Richard C Davis, Aldons J Lusis and Eleazar Eskin

Natural Selection Reduced Diversity on Human Y Chromosomes pp. 1-12

Melissa A Wilson Sayres, Kirk E Lohmueller and Rasmus Nielsen

Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan pp. 1-12

Alexander M Kulminski, Konstantin G Arbeev, Irina Culminskaya, Liubov Arbeeva, Svetlana V Ukraintseva, Eric Stallard, Kaare Christensen, Nicole Schupf, Michael A Province and Anatoli I Yashin