Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Ying Wu, Lindsay L Waite, Anne U Jackson, Wayne H-H Sheu, Steven Buyske, Devin Absher, Donna K Arnett, Eric Boerwinkle, Lori L Bonnycastle, Cara L Carty, Iona Cheng, Barbara Cochran, Damien C Croteau-Chonka, Logan Dumitrescu, Charles B Eaton, Nora Franceschini, Xiuqing Guo, Brian E Henderson, Lucia A Hindorff, Eric Kim, Leena Kinnunen, Pirjo Komulainen, Wen-Jane Lee, Loic Le Marchand, Yi Lin, Jaana Lindström, Oddgeir Lingaas-Holmen, Sabrina L Mitchell, Narisu Narisu, Jennifer G Robinson, Fred Schumacher, Alena Stančáková, Jouko Sundvall, Yun-Ju Sung, Amy J Swift, Wen-Chang Wang, Lynne Wilkens, Tom Wilsgaard, Alicia M Young, Linda S Adair, Christie M Ballantyne, Petra Bůžková, Aravinda Chakravarti, Francis S Collins, David Duggan, Alan B Feranil, Low-Tone Ho, Yi-Jen Hung, Steven C Hunt, Kristian Hveem, Jyh-Ming J Juang, Antero Y Kesäniemi, Johanna Kuusisto, Markku Laakso, Timo A Lakka, I-Te Lee, Mark F Leppert, Tara C Matise, Leena Moilanen, Inger Njølstad, Ulrike Peters, Thomas Quertermous, Rainer Rauramaa, Jerome I Rotter, Jouko Saramies, Jaakko Tuomilehto, Matti Uusitupa, Tzung-Dau Wang, Michael Boehnke, Christopher A Haiman, Yii- Der I Chen, Charles Kooperberg, Themistocles L Assimes, Dana C Crawford, Chao A Hsiung, Kari E North and Karen L Mohlke

PLOS Genetics, 2013, vol. 9, issue 3, 1-16

Abstract: Genome-wide association studies (GWAS) have identified ∼100 loci associated with blood lipid levels, but much of the trait heritability remains unexplained, and at most loci the identities of the trait-influencing variants remain unknown. We conducted a trans-ethnic fine-mapping study at 18, 22, and 18 GWAS loci on the Metabochip for their association with triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), respectively, in individuals of African American (n = 6,832), East Asian (n = 9,449), and European (n = 10,829) ancestry. We aimed to identify the variants with strongest association at each locus, identify additional and population-specific signals, refine association signals, and assess the relative significance of previously described functional variants. Among the 58 loci, 33 exhibited evidence of association at P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1003379

DOI: 10.1371/journal.pgen.1003379

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