Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease

Andrea Ganna, Samira Salihovic, Johan Sundström, Corey D Broeckling, Åsa K Hedman, Patrik K E Magnusson, Nancy L Pedersen, Anders Larsson, Agneta Siegbahn, Mihkel Zilmer, Jessica Prenni, Johan Ärnlöv, Lars Lind, Tove Fall and Erik Ingelsson

PLOS Genetics, 2014, vol. 10, issue 12, 1-10

Abstract: Analyses of circulating metabolites in large prospective epidemiological studies could lead to improved prediction and better biological understanding of coronary heart disease (CHD). We performed a mass spectrometry-based non-targeted metabolomics study for association with incident CHD events in 1,028 individuals (131 events; 10 y. median follow-up) with validation in 1,670 individuals (282 events; 3.9 y. median follow-up). Four metabolites were replicated and independent of main cardiovascular risk factors [lysophosphatidylcholine 18∶1 (hazard ratio [HR] per standard deviation [SD] increment = 0.77, P-value

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1004801

DOI: 10.1371/journal.pgen.1004801

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