Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

Lauc, Gordan; Huffman, Jennifer E; Pučić, Maja; Zgaga, Lina; Adamczyk, Barbara; Mužinić, Ana; Novokmet, Mislav; Polašek, Ozren; Gornik, Olga; Krištić, Jasminka; Keser, Toma; Vitart, Veronique; Scheijen, Blanca; Uh, Hae-Won; Molokhia, Mariam; Patrick, Alan Leslie; McKeigue, Paul; Kolčić, Ivana; Lukić, Ivan Krešimir; Swann, Olivia; van Leeuwen, Frank N; Ruhaak, L Renee; Houwing-Duistermaat, Jeanine J; Slagboom, P Eline; Beekman, Marian; de Craen, Anton J M; Deelder, André M; Zeng, Qiang; Wang, Wei; Hastie, Nicholas D; Gyllensten, Ulf; Wilson, James F; Wuhrer, Manfred; Wright, Alan F; Rudd, Pauline M; Hayward, Caroline; Aulchenko, Yurii; Campbell, Harry; Rudan, Igor

Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

Gordan Lauc, Jennifer E Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Leslie Patrick, Paul McKeigue, Ivana Kolčić, Ivan Krešimir Lukić, Olivia Swann, Frank N van Leeuwen, L Renee Ruhaak, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Marian Beekman, Anton J M de Craen, André M Deelder, Qiang Zeng, Wei Wang, Nicholas D Hastie, Ulf Gyllensten, James F Wilson, Manfred Wuhrer, Alan F Wright, Pauline M Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell and Igor Rudan

PLOS Genetics, 2013, vol. 9, issue 1, 1-17

Abstract: Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG from human plasma, we performed 77 quantitative measurements of N-glycosylation using ultra-performance liquid chromatography (UPLC) in 2,247 individuals from four European discovery populations. In parallel, we measured IgG N-glycans using MALDI-TOF mass spectrometry (MS) in a replication cohort of 1,848 Europeans. Meta-analysis of genome-wide association study (GWAS) results identified 9 genome-wide significant loci (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1003225

DOI: 10.1371/journal.pgen.1003225

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