PLOS Genetics

2005 - 2022

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Volume 12, issue 12, 2016

Deep Reads: Favorites from a Few Different Shelves pp. 1-6

Bruce A Hamilton

Bringing PLOS Genetics Editors to Preprint Servers pp. 1-2

Gregory S Barsh, Casey M Bergman, Christopher D Brown, Nadia D Singh and Gregory P Copenhaver

Correction: Gene Expansion Shapes Genome Architecture in the Human Pathogen Lichtheimia corymbifera: An Evolutionary Genomics Analysis in the Ancient Terrestrial Mucorales (Mucoromycotina) pp. 1-1

Volker U Schwartze, Sascha Winter, Ekaterina Shelest, Marina Marcet-Houben, Fabian Horn, Stefanie Wehner, Jörg Linde, Vito Valiante, Michael Sammeth, Konstantin Riege, Minou Nowrousian, Kerstin Kaerger, Ilse D Jacobsen, Manja Marz, Axel A Brakhage, Toni Gabaldón, Sebastian Böcker and Kerstin Voigt

Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data pp. 1-24

Jianxin Shi, Ju-Hyun Park, Jubao Duan, Sonja T Berndt, Winton Moy, Kai Yu, Lei Song, William Wheeler, Xing Hua, Debra Silverman, Montserrat Garcia-Closas, Chao Agnes Hsiung, Jonine D Figueroa, Victoria K Cortessis, Núria Malats, Margaret R Karagas, Paolo Vineis, I-Shou Chang, Dongxin Lin, Baosen Zhou, Adeline Seow, Keitaro Matsuo, Yun-Chul Hong, Neil E Caporaso, Brian Wolpin, Eric Jacobs, Gloria M Petersen, Alison P Klein, Donghui Li, Harvey Risch, Alan R Sanders, Li Hsu, Robert E Schoen, Hermann Brenner, (Molecular Genetics of Schizophrenia) GWAS Consortium Mgs, GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium), The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium, (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium Practical, PanScan Consortium, The GAME-ON/ELLIPSE Consortium, Rachael Stolzenberg-Solomon, Pablo Gejman, Qing Lan, Nathaniel Rothman, Laufey T Amundadottir, Maria Teresa Landi, Douglas F Levinson, Stephen J Chanock and Nilanjan Chatterjee

Volume 12, issue 11, 2016

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality pp. 1-20

Alexander M Kulminski, Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G Arbeev, Elena Loiko, Liubov Arbeeva, Olivia Bagley, Matt Duan, Arseniy Yashkin, Fang Fang, Mikhail Kovtun, Svetlana V Ukraintseva, Deqing Wu and Anatoliy I Yashin

Suggestions from Geroscience for the Genetics of Age-Related Diseases pp. 1-4

Claudio Franceschi and Paolo Garagnani

Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues pp. 1-23

Heather E Wheeler, Kaanan P Shah, Jonathon Brenner, Tzintzuni Garcia, Keston Aquino-Michaels, GTEx Consortium, Nancy J Cox, Dan L Nicolae and Hae Kyung Im

Volume 12, issue 10, 2016

CERAMIC: Case-Control Association Testing in Samples with Related Individuals, Based on Retrospective Mixed Model Analysis with Adjustment for Covariates pp. 1-28

Sheng Zhong, Duo Jiang and Mary Sara McPeek

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study pp. 1-20

Emma C Johnson, Douglas W Bjelland, Daniel P Howrigan, Abdel Abdellaoui, Gerome Breen, Anders Borglum, Sven Cichon, Franziska Degenhardt, Andreas J Forstner, Josef Frank, Giulio Genovese, Stefanie Heilmann-Heimbach, Stefan Herms, Per Hoffman, Wolfgang Maier, Manuel Mattheisen, Derek Morris, Bryan Mowry, Betram Müller-Mhysok, Benjamin Neale, Igor Nenadic, Markus M Nöthen, Colm O’Dushlaine, Marcella Rietschel, Douglas M Ruderfer, Dan Rujescu, Thomas G Schulze, Matthew A Simonson, Eli Stahl, Jana Strohmaier, Stephanie H Witt, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patrick F Sullivan and Matthew C Keller

A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records pp. 1-20

Thomas J Hoffmann, Bronya J Keats, Noriko Yoshikawa, Catherine Schaefer, Neil Risch and Lawrence R Lustig

Volume 12, issue 9, 2016

The Impact of Endurance Training on Human Skeletal Muscle Memory, Global Isoform Expression and Novel Transcripts pp. 1-24

Maléne E Lindholm, Stefania Giacomello, Beata Werne Solnestam, Helene Fischer, Mikael Huss, Sanela Kjellqvist and Carl Johan Sundberg

Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy pp. 1-24

Stacey D Wagner, Adam J Struck, Riti Gupta, Dylan R Farnsworth, Amy E Mahady, Katy Eichinger, Charles A Thornton, Eric T Wang and J Andrew Berglund

Using Genetic Distance to Infer the Accuracy of Genomic Prediction pp. 1-19

Marco Scutari, Ian Mackay and David Balding

Volume 12, issue 8, 2016

Phenotypic Plasticity through Transcriptional Regulation of the Evolutionary Hotspot Gene tan in Drosophila melanogaster pp. 1-22

Jean-Michel Gibert, Emmanuèle Mouchel-Vielh, Sandra De Castro and Frédérique Peronnet

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci pp. 1-19

Samuel E Jones, Jessica Tyrrell, Andrew R Wood, Robin N Beaumont, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Youna Hu, Maris Teder-Laving, Caroline Hayward, Till Roenneberg, James F Wilson, Fabiola Del Greco, Andrew A Hicks, Chol Shin, Chang-Ho Yun, Seung Ku Lee, Andres Metspalu, Enda M Byrne, Philip R Gehrman, Henning Tiemeier, Karla V Allebrandt, Rachel M Freathy, Anna Murray, David A Hinds, Timothy M Frayling and Michael N Weedon

Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape pp. 1-19

Joanne B Cole, Mange Manyama, Emmanuel Kimwaga, Joshua Mathayo, Jacinda R Larson, Denise K Liberton, Ken Lukowiak, Tracey M Ferrara, Sheri L Riccardi, Mao Li, Washington Mio, Michaela Prochazkova, Trevor Williams, Hong Li, Kenneth L Jones, Ophir D Klein, Stephanie A Santorico, Benedikt Hallgrimsson and Richard A Spritz

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD pp. 1-33

Wei Sun, Katerina Kechris, Sean Jacobson, M Bradley Drummond, Gregory A Hawkins, Jenny Yang, Ting-huei Chen, Pedro Miguel Quibrera, Wayne Anderson, R Graham Barr, Patricia V Basta, Eugene R Bleecker, Terri Beaty, Richard Casaburi, Peter Castaldi, Michael H Cho, Alejandro Comellas, James D Crapo, Gerard Criner, Dawn Demeo, Stephanie A Christenson, David J Couper, Jeffrey L Curtis, Claire M Doerschuk, Christine M Freeman, Natalia A Gouskova, MeiLan K Han, Nicola A Hanania, Nadia N Hansel, Craig P Hersh, Eric A Hoffman, Robert J Kaner, Richard E Kanner, Eric C Kleerup, Sharon Lutz, Fernando J Martinez, Deborah A Meyers, Stephen P Peters, Elizabeth A Regan, Stephen I Rennard, Mary Beth Scholand, Edwin K Silverman, Prescott G Woodruff, Wanda K O’Neal, Russell P Bowler, Research Group Spiromics and COPDGene Investigators

Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology pp. 1-21

John R Shaffer, Ekaterina Orlova, Myoung Keun Lee, Elizabeth J Leslie, Zachary D Raffensperger, Carrie L Heike, Michael L Cunningham, Jacqueline T Hecht, Chung How Kau, Nichole L Nidey, Lina M Moreno, George L Wehby, Jeffrey C Murray, Cecelia A Laurie, Cathy C Laurie, Joanne Cole, Tracey Ferrara, Stephanie Santorico, Ophir Klein, Washington Mio, Eleanor Feingold, Benedikt Hallgrimsson, Richard A Spritz, Mary L Marazita and Seth M Weinberg

Functional Translational Readthrough: A Systems Biology Perspective pp. 1-12

Fabian Schueren and Sven Thoms

Volume 12, issue 7, 2016

Selection on Network Dynamics Drives Differential Rates of Protein Domain Evolution pp. 1-20

Brian K Mannakee and Ryan N Gutenkunst

Volume 12, issue 6, 2016

Bias Characterization in Probabilistic Genotype Data and Improved Signal Detection with Multiple Imputation pp. 1-17

Cameron Palmer and Itsik Pe’er

Functional Assessment of Genetic Variants with Outcomes Adapted to Clinical Decision-Making pp. 1-27

Pierre Thouvenot, Barbara Ben Yamin, Lou Fourrière, Aurianne Lescure, Thomas Boudier, Elaine Del Nery, Anne Chauchereau, David E Goldgar, Claude Houdayer, Dominique Stoppa-Lyonnet, Alain Nicolas and Gaël A Millot

A Powerful Procedure for Pathway-Based Meta-analysis Using Summary Statistics Identifies 43 Pathways Associated with Type II Diabetes in European Populations pp. 1-28

Han Zhang, William Wheeler, Paula L Hyland, Yifan Yang, Jianxin Shi, Nilanjan Chatterjee and Kai Yu

Volume 12, issue 5, 2016

Testing Rare-Variant Association without Calling Genotypes Allows for Systematic Differences in Sequencing between Cases and Controls pp. 1-19

Yi-Juan Hu, Peizhou Liao, H Richard Johnston, Andrew S Allen and Glen A Satten

The Great Migration and African-American Genomic Diversity pp. 1-27

Soheil Baharian, Maxime Barakatt, Christopher R Gignoux, Suyash Shringarpure, Jacob Errington, William J Blot, Carlos D Bustamante, Eimear E Kenny, Scott M Williams, Melinda C Aldrich and Simon Gravel

A Novel Mutant Allele of Pw1/Peg3 Does Not Affect Maternal Behavior or Nursing Behavior pp. 1-20

Anne-Lyse Denizot, Vanessa Besson, Rosa Maria Correra, Alessia Mazzola, Izolina Lopes, Jean-Remy Courbard, Giovanna Marazzi and David A Sassoon

Volume 12, issue 4, 2016

Functional Regression Models for Epistasis Analysis of Multiple Quantitative Traits pp. 1-26

Futao Zhang, Dan Xie, Meimei Liang and Momiao Xiong

The Increasing Importance of Gene-Based Analyses pp. 1-12

Elizabeth T Cirulli

Volume 12, issue 3, 2016

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models pp. 1-19

Jae Hoon Sul, Michael Bilow, Wen-Yun Yang, Emrah Kostem, Nick Furlotte, Dan He and Eleazar Eskin

S/HIC: Robust Identification of Soft and Hard Sweeps Using Machine Learning pp. 1-31

Daniel R Schrider and Andrew D Kern

Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene pp. 1-21

Kerstin U Ludwig, Syeda Tasnim Ahmed, Anne C Böhmer, Nasim Bahram Sangani, Sheryil Varghese, Johanna Klamt, Hannah Schuenke, Pinar Gültepe, Andrea Hofmann, Michele Rubini, Khalid Ahmed Aldhorae, Regine P Steegers-Theunissen, Augusto Rojas-Martinez, Rudolf Reiter, Guntram Borck, Michael Knapp, Mitsushiro Nakatomi, Daniel Graf, Elisabeth Mangold and Heiko Peters

Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number pp. 1-21

Manja Wachsmuth, Alexander Hübner, Mingkun Li, Burkhard Madea and Mark Stoneking

Volume 12, issue 2, 2016

Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation pp. 1-25

Charley Xia, Carmen Amador, Jennifer Huffman, Holly Trochet, Archie Campbell, David Porteous, Generation Scotland, Nicholas D Hastie, Caroline Hayward, Veronique Vitart, Pau Navarro and Chris S Haley

Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies pp. 1-23

Seung Hoan Choi, Daniela Ruggiero, Rossella Sorice, Ci Song, Teresa Nutile, Albert Vernon Smith, Maria Pina Concas, Michela Traglia, Caterina Barbieri, Ndeye Coumba Ndiaye, Maria G Stathopoulou, Vasiliki Lagou, Giovanni Battista Maestrale, Cinzia Sala, Stephanie Debette, Peter Kovacs, Lars Lind, John Lamont, Peter Fitzgerald, Anke Tönjes, Vilmundur Gudnason, Daniela Toniolo, Mario Pirastu, Celine Bellenguez, Ramachandran S Vasan, Erik Ingelsson, Anne-Louise Leutenegger, Andrew D Johnson, Anita L DeStefano, Sophie Visvikis-Siest, Sudha Seshadri and Marina Ciullo

GBStools: A Statistical Method for Estimating Allelic Dropout in Reduced Representation Sequencing Data pp. 1-18

Thomas F Cooke, Muh-Ching Yee, Marina Muzzio, Alexandra Sockell, Ryan Bell, Omar E Cornejo, Joanna L Kelley, Graciela Bailliet, Claudio M Bravi, Carlos D Bustamante and Eimear E Kenny

Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies pp. 1-24

Xiaolei Liu, Meng Huang, Bin Fan, Edward S Buckler and Zhiwu Zhang

Volume 12, issue 1, 2016

Consent Codes: Upholding Standard Data Use Conditions pp. 1-9

Stephanie O M Dyke, Anthony A Philippakis, Jordi Rambla De Argila, Dina N Paltoo, Erin S Luetkemeier, Bartha M Knoppers, Anthony J Brookes, J Dylan Spalding, Mark Thompson, Marco Roos, Kym M Boycott, Michael Brudno, Matthew Hurles, Heidi L Rehm, Andreas Matern, Marc Fiume and Stephen T Sherry

A Spatial Framework for Understanding Population Structure and Admixture pp. 1-38

Gideon S Bradburd, Peter L Ralph and Graham M Coop

Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila pp. 1-17

Arunesh Saras and Mark A Tanouye

Volume 11, issue 12, 2015

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity pp. 1-23

Kristen Fortney, Edgar Dobriban, Paolo Garagnani, Chiara Pirazzini, Daniela Monti, Daniela Mari, Gil Atzmon, Nir Barzilai, Claudio Franceschi, Art B Owen and Stuart K Kim

PLOS Genetics Data Sharing Policy: In Pursuit of Functional Utility pp. 1-5

Gregory S Barsh, Gregory M Cooper, Gregory P Copenhaver, Greg Gibson, Mark I McCarthy, Hua Tang and Scott M Williams

Estimating Information Processing in a Memory System: The Utility of Meta-analytic Methods for Genetics pp. 1-27

Tugce Yildizoglu, Jan-Marek Weislogel, Farhan Mohammad, Edwin S-Y Chan, Pryseley N Assam and Adam Claridge-Chang

Genomic Insights into the Ancestry and Demographic History of South America pp. 1-26

Julian R Homburger, Andrés Moreno-Estrada, Christopher R Gignoux, Dominic Nelson, Elena Sanchez, Patricia Ortiz-Tello, Bernardo A Pons-Estel, Eduardo Acevedo-Vasquez, Pedro Miranda, Carl D Langefeld, Simon Gravel, Marta E Alarcón-Riquelme and Carlos D Bustamante

Integration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer pp. 1-22

Silvia Pineda, Francisco X Real, Manolis Kogevinas, Alfredo Carrato, Stephen J Chanock, Núria Malats and Kristel Van Steen

An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies pp. 1-21

Wesley K Thompson, Yunpeng Wang, Andrew J Schork, Aree Witoelar, Verena Zuber, Shujing Xu, Thomas Werge, Dominic Holland, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Ole A Andreassen and Anders M Dale

Understanding Biases in Ribosome Profiling Experiments Reveals Signatures of Translation Dynamics in Yeast pp. 1-25

Jeffrey A Hussmann, Stephanie Patchett, Arlen Johnson, Sara Sawyer and William H Press

Women Who Don't Give a Crap pp. 1-6

Holly Tabor

Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s pp. 1-14

Michele Carbone, Erin G Flores, Mitsuru Emi, Todd A Johnson, Tatsuhiko Tsunoda, Dusty Behner, Harriet Hoffman, Mary Hesdorffer, Masaki Nasu, Andrea Napolitano, Amy Powers, Michael Minaai, Francine Baumann, Peter Bryant-Greenwood, Olivia Lauk, Michaela B Kirschner, Walter Weder, Isabelle Opitz, Harvey I Pass, Giovanni Gaudino, Sandra Pastorino and Haining Yang

Volume 11, issue 11, 2015

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis pp. 1-24

William E Kraus, Deborah M Muoio, Robert Stevens, Damian Craig, James R Bain, Elizabeth Grass, Carol Haynes, Lydia Kwee, Xuejun Qin, Dorothy H Slentz, Deidre Krupp, Michael Muehlbauer, Elizabeth R Hauser, Simon G Gregory, Christopher B Newgard and Svati H Shah

Ernst Rüdin and the State of Science pp. 1-3

Michael Yudell

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes pp. 1-25

Mark Lipson, Po-Ru Loh, Sriram Sankararaman, Nick Patterson, Bonnie Berger and David Reich

Convergent Evolution During Local Adaptation to Patchy Landscapes pp. 1-31

Peter L Ralph and Graham Coop

A Flexible, Efficient Binomial Mixed Model for Identifying Differential DNA Methylation in Bisulfite Sequencing Data pp. 1-31

Amanda J Lea, Jenny Tung and Xiang Zhou

Volume 11, issue 10, 2015

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study pp. 1-42

Thomas W Winkler, Anne E Justice, Mariaelisa Graff, Llilda Barata, Mary F Feitosa, Su Chu, Jacek Czajkowski, Tõnu Esko, Tove Fall, Tuomas O Kilpeläinen, Yingchang Lu, Reedik Mägi, Evelin Mihailov, Tune H Pers, Sina Rüeger, Alexander Teumer, Georg B Ehret, Teresa Ferreira, Nancy L Heard-Costa, Juha Karjalainen, Vasiliki Lagou, Anubha Mahajan, Michael D Neinast, Inga Prokopenko, Jeannette Simino, Tanya M Teslovich, Rick Jansen, Harm-Jan Westra, Charles C White, Devin Absher, Tarunveer S Ahluwalia, Shafqat Ahmad, Eva Albrecht, Alexessander Couto Alves, Jennifer L Bragg-Gresham, Anton J M de Craen, Joshua C Bis, Amélie Bonnefond, Gabrielle Boucher, Gemma Cadby, Yu-Ching Cheng, Charleston W K Chiang, Graciela Delgado, Ayse Demirkan, Nicole Dueker, Niina Eklund, Gudny Eiriksdottir, Joel Eriksson, Bjarke Feenstra, Krista Fischer, Francesca Frau, Tessel E Galesloot, Frank Geller, Anuj Goel, Mathias Gorski, Tanja B Grammer, Stefan Gustafsson, Saskia Haitjema, Jouke-Jan Hottenga, Jennifer E Huffman, Anne U Jackson, Kevin B Jacobs, Åsa Johansson, Marika Kaakinen, Marcus E Kleber, Jari Lahti, Irene Mateo Leach, Benjamin Lehne, Youfang Liu, Ken Sin Lo, Mattias Lorentzon, Jian'an Luan, Pamela A F Madden, Massimo Mangino, Barbara McKnight, Carolina Medina-Gomez, Keri L Monda, May E Montasser, Gabriele Müller, Martina Müller-Nurasyid, Ilja M Nolte, Kalliope Panoutsopoulou, Laura Pascoe, Lavinia Paternoster, Nigel W Rayner, Frida Renström, Federica Rizzi, Lynda M Rose, Kathy A Ryan, Perttu Salo, Serena Sanna, Hubert Scharnagl, Jianxin Shi, Albert Vernon Smith, Lorraine Southam, Alena Stančáková, Valgerdur Steinthorsdottir, Rona J Strawbridge, Yun Ju Sung, Ioanna Tachmazidou, Toshiko Tanaka, Gudmar Thorleifsson, Stella Trompet, Natalia Pervjakova, Jonathan P Tyrer, Liesbeth Vandenput, Sander W van der Laan, Nathalie van der Velde, Jessica van Setten, Jana V van Vliet-Ostaptchouk, Niek Verweij, Efthymia Vlachopoulou, Lindsay L Waite, Sophie R Wang, Zhaoming Wang, Sarah H Wild, Christina Willenborg, James F Wilson, Andrew Wong, Jian Yang, Loïc Yengo, Laura M Yerges-Armstrong, Lei Yu, Weihua Zhang, Jing Hua Zhao, Ehm A Andersson, Stephan J L Bakker, Damiano Baldassarre, Karina Banasik, Matteo Barcella, Cristina Barlassina, Claire Bellis, Paola Benaglio, John Blangero, Matthias Blüher, Fabrice Bonnet, Lori L Bonnycastle, Heather A Boyd, Marcel Bruinenberg, Aron S Buchman, Harry Campbell, Yii- Der Ida Chen, Peter S Chines, Simone Claudi-Boehm, John Cole, Francis S Collins, Eco J C de Geus, Lisette C P G M de Groot, Maria Dimitriou, Jubao Duan, Stefan Enroth, Elodie Eury, Aliki-Eleni Farmaki, Nita G Forouhi, Nele Friedrich, Pablo V Gejman, Bruna Gigante, Nicola Glorioso, Alan S Go, Omri Gottesman, Jürgen Gräßler, Harald Grallert, Niels Grarup, Yu-Mei Gu, Linda Broer, Annelies C Ham, Torben Hansen, Tamara B Harris, Catharina A Hartman, Maija Hassinen, Nicholas Hastie, Andrew T Hattersley, Andrew C Heath, Anjali K Henders, Dena Hernandez, Hans Hillege, Oddgeir Holmen, Kees G Hovingh, Jennie Hui, Lise L Husemoen, Nina Hutri-Kähönen, Pirro G Hysi, Thomas Illig, Philip L De Jager, Shapour Jalilzadeh, Torben Jørgensen, J Wouter Jukema, Markus Juonala, Stavroula Kanoni, Maria Karaleftheri, Kay Tee Khaw, Leena Kinnunen, Steven J Kittner, Wolfgang Koenig, Ivana Kolcic, Peter Kovacs, Nikolaj T Krarup, Wolfgang Kratzer, Janine Krüger, Diana Kuh, Meena Kumari, Theodosios Kyriakou, Claudia Langenberg, Lars Lannfelt, Chiara Lanzani, Vaneet Lotay, Lenore J Launer, Karin Leander, Jaana Lindström, Allan Linneberg, Yan-Ping Liu, Stéphane Lobbens, Robert Luben, Valeriya Lyssenko, Satu Männistö, Patrik K Magnusson, Wendy L McArdle, Cristina Menni, Sigrun Merger, Lili Milani, Grant W Montgomery, Andrew P Morris, Narisu Narisu, Mari Nelis, Ken K Ong, Aarno Palotie, Louis Pérusse, Irene Pichler, Maria G Pilia, Anneli Pouta, Myriam Rheinberger, Rasmus Ribel-Madsen, Marcus Richards, Kenneth M Rice, Treva K Rice, Carlo Rivolta, Veikko Salomaa, Alan R Sanders, Mark A Sarzynski, Salome Scholtens, Robert A Scott, William R Scott, Sylvain Sebert, Sebanti Sengupta, Bengt Sennblad, Thomas Seufferlein, Angela Silveira, P Eline Slagboom, Jan H Smit, Thomas H Sparsø, Kathleen Stirrups, Ronald P Stolk, Heather M Stringham, Morris A Swertz, Amy J Swift, Ann-Christine Syvänen, Sian-Tsung Tan, Barbara Thorand, Anke Tönjes, Angelo Tremblay, Emmanouil Tsafantakis, Peter J van der Most, Uwe Völker, Marie-Claude Vohl, Judith M Vonk, Melanie Waldenberger, Ryan W Walker, Roman Wennauer, Elisabeth Widén, Gonneke Willemsen, Tom Wilsgaard, Alan F Wright, M Carola Zillikens, Suzanne C van Dijk, Natasja M van Schoor, Folkert W Asselbergs, Paul I W de Bakker, Jacques S Beckmann, John Beilby, David A Bennett, Richard N Bergman, Sven Bergmann, Carsten A Böger, Bernhard O Boehm, Eric Boerwinkle, Dorret I Boomsma, Stefan R Bornstein, Erwin P Bottinger, Claude Bouchard, John C Chambers, Stephen J Chanock, Daniel I Chasman, Francesco Cucca, Daniele Cusi, George Dedoussis, Jeanette Erdmann, Johan G Eriksson, Denis A Evans, Ulf de Faire, Martin Farrall, Luigi Ferrucci, Ian Ford, Lude Franke, Paul W Franks, Philippe Froguel, Ron T Gansevoort, Christian Gieger, Henrik Grönberg, Vilmundur Gudnason, Ulf Gyllensten, Per Hall, Anders Hamsten, Pim van der Harst, Caroline Hayward, Markku Heliövaara, Christian Hengstenberg, Andrew A Hicks, Aroon Hingorani, Albert Hofman, Frank Hu, Heikki V Huikuri, Kristian Hveem, Alan L James, Joanne M Jordan, Antti Jula, Mika Kähönen, Eero Kajantie, Sekar Kathiresan, Lambertus A L M Kiemeney, Mika Kivimaki, Paul B Knekt, Heikki A Koistinen, Jaspal S Kooner, Seppo Koskinen, Johanna Kuusisto, Winfried Maerz, Nicholas G Martin, Markku Laakso, Timo A Lakka, Terho Lehtimäki, Guillaume Lettre, Douglas F Levinson, Lars Lind, Marja-Liisa Lokki, Pekka Mäntyselkä, Mads Melbye, Andres Metspalu, Braxton D Mitchell, Frans L Moll, Jeffrey C Murray, Arthur W Musk, Markku S Nieminen, Inger Njølstad, Claes Ohlsson, Albertine J Oldehinkel, Ben A Oostra, Lyle J Palmer, James S Pankow, Gerard Pasterkamp, Nancy L Pedersen, Oluf Pedersen, Brenda W Penninx, Markus Perola, Annette Peters, Ozren Polašek, Peter P Pramstaller, Bruce M Psaty, Lu Qi, Thomas Quertermous, Olli T Raitakari, Tuomo Rankinen, Rainer Rauramaa, Paul M Ridker, John D Rioux, Fernando Rivadeneira, Jerome I Rotter, Igor Rudan, Hester M den Ruijter, Juha Saltevo, Naveed Sattar, Heribert Schunkert, Peter E H Schwarz, Alan R Shuldiner, Juha Sinisalo, Harold Snieder, Thorkild I A Sørensen, Tim D Spector, Jan A Staessen, Bandinelli Stefania, Unnur Thorsteinsdottir, Michael Stumvoll, Jean-Claude Tardif, Elena Tremoli, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, André L M Verbeek, Sita H Vermeulen, Jorma S Viikari, Veronique Vitart, Henry Völzke, Peter Vollenweider, Gérard Waeber, Mark Walker, Henri Wallaschofski, Nicholas J Wareham, Hugh Watkins, Eleftheria Zeggini, Consortium Charge, Consortium Diagram, Consortium Glgc, Global-BPGen Consortium, Consortium Icbp, Consortium Magic, Aravinda Chakravarti, Deborah J Clegg, L Adrienne Cupples, Penny Gordon-Larsen, Cashell E Jaquish, D C Rao, Goncalo R Abecasis, Themistocles L Assimes, Inês Barroso, Sonja I Berndt, Michael Boehnke, Panos Deloukas, Caroline S Fox, Leif C Groop, David J Hunter, Erik Ingelsson, Robert C Kaplan, Mark I McCarthy, Karen L Mohlke, Jeffrey R O'Connell, David Schlessinger, David P Strachan, Kari Stefansson, Cornelia M van Duijn, Joel N Hirschhorn, Cecilia M Lindgren, Iris M Heid, Kari E North, Ingrid B Borecki, Zoltán Kutalik and Ruth J F Loos

A Decad(e) of Reasons to Contribute to a PLOS Community-Run Journal pp. 1-6

Gregory P Copenhaver and Gregory S Barsh

A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers pp. 1-17

Miles C Benton, Rodney A Lea, Donia Macartney-Coxson, Michelle Hanna, David A Eccles, Melanie A Carless, Geoffrey K Chambers, Claire Bellis, Harald H Goring, Joanne E Curran, Jacquie L Harper, Gregory Gibson, John Blangero and Lyn R Griffiths

Your Data to Explore: An Interview with Anne Wojcicki pp. 1-9

Jane Gitschier

Genome-Wide Association Analysis of Adaptation Using Environmentally Predicted Traits pp. 1-23

Joost van Heerwaarden, Martijn van Zanten and Willem Kruijer

A New Method for Detecting Associations with Rare Copy-Number Variants pp. 1-24

Jung-Ying Tzeng, Patrik K E Magnusson, Patrick F Sullivan, The Swedish Schizophrenia Consortium and Jin P Szatkiewicz

Volume 11, issue 9, 2015

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism pp. 1-23

Anu Loukola, Jadwiga Buchwald, Richa Gupta, Teemu Palviainen, Jenni Hällfors, Emmi Tikkanen, Tellervo Korhonen, Miina Ollikainen, Antti-Pekka Sarin, Samuli Ripatti, Terho Lehtimäki, Olli Raitakari, Veikko Salomaa, Richard J Rose, Rachel F Tyndale and Jaakko Kaprio

Discovering Genetic Interactions in Large-Scale Association Studies by Stage-wise Likelihood Ratio Tests pp. 1-24

Mattias Frånberg, Karl Gertow, Anders Hamsten, Consortium Procardis, Jens Lagergren and Bengt Sennblad

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci pp. 1-14

Martijn van de Bunt, Adrian Cortes, Consortium Igas, Matthew A Brown, Andrew P Morris and Mark I McCarthy

Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele pp. 1-27

Roy Ronen, Glenn Tesler, Ali Akbari, Shay Zakov, Noah A Rosenberg and Vineet Bafna

Volume 11, issue 8, 2015

Regulation of Mutagenic DNA Polymerase V Activation in Space and Time pp. 1-30

Andrew Robinson, John P McDonald, Victor E A Caldas, Meghna Patel, Elizabeth A Wood, Christiaan M Punter, Harshad Ghodke, Michael M Cox, Roger Woodgate, Myron F Goodman and Antoine M van Oijen

Evidence for a Common Origin of Blacksmiths and Cultivators in the Ethiopian Ari within the Last 4500 Years: Lessons for Clustering-Based Inference pp. 1-49

Lucy van Dorp, David Balding, Simon Myers, Luca Pagani, Chris Tyler-Smith, Endashaw Bekele, Ayele Tarekegn, Mark G Thomas, Neil Bradman and Garrett Hellenthal

New Routes to Phylogeography: A Bayesian Structured Coalescent Approximation pp. 1-22

Nicola De Maio, Chieh-Hsi Wu, Kathleen M O’Reilly and Daniel Wilson

Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND) pp. 1-19

Sudha K Iyengar, John R Sedor, Barry I Freedman, W H Linda Kao, Matthias Kretzler, Benjamin J Keller, Hanna E Abboud, Sharon G Adler, Lyle G Best, Donald W Bowden, Allison Burlock, Yii- Der Ida Chen, Shelley A Cole, Mary E Comeau, Jeffrey M Curtis, Jasmin Divers, Christiane Drechsler, Ravi Duggirala, Robert C Elston, Xiuqing Guo, Huateng Huang, Michael Marcus Hoffmann, Barbara V Howard, Eli Ipp, Paul L Kimmel, Michael J Klag, William C Knowler, Orly F Kohn, Tennille S Leak, David J Leehey, Man Li, Alka Malhotra, Winfried März, Viji Nair, Robert G Nelson, Susanne B Nicholas, Stephen J O’Brien, Madeleine V Pahl, Rulan S Parekh, Marcus G Pezzolesi, Rebekah S Rasooly, Charles N Rotimi, Jerome I Rotter, Jeffrey R Schelling, Michael F Seldin, Vallabh O Shah, Adam M Smiles, Michael W Smith, Kent D Taylor, Farook Thameem, Denyse P Thornley-Brown, Barbara J Truitt, Christoph Wanner, E Jennifer Weil, Cheryl A Winkler, Philip G Zager, Robert P Igo, Robert L Hanson, Carl D Langefeld and Family Investigation of Nephropathy and Diabetes (FIND)

Volume 11, issue 7, 2015

AAA-ATPase FIDGETIN-LIKE 1 and Helicase FANCM Antagonize Meiotic Crossovers by Distinct Mechanisms pp. 1-22

Chloe Girard, Liudmila Chelysheva, Sandrine Choinard, Nicole Froger, Nicolas Macaisne, Afef Lehmemdi, Julien Mazel, Wayne Crismani and Raphael Mercier

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation pp. 1-24

Momoko Horikoshi, Reedik Mӓgi, Martijn van de Bunt, Ida Surakka, Antti-Pekka Sarin, Anubha Mahajan, Letizia Marullo, Gudmar Thorleifsson, Sara Hӓgg, Jouke-Jan Hottenga, Claes Ladenvall, Janina S Ried, Thomas W Winkler, Sara M Willems, Natalia Pervjakova, Tõnu Esko, Marian Beekman, Christopher P Nelson, Christina Willenborg, Steven Wiltshire, Teresa Ferreira, Juan Fernandez, Kyle J Gaulton, Valgerdur Steinthorsdottir, Anders Hamsten, Patrik K E Magnusson, Gonneke Willemsen, Yuri Milaneschi, Neil R Robertson, Christopher J Groves, Amanda J Bennett, Terho Lehtimӓki, Jorma S Viikari, Johan Rung, Valeriya Lyssenko, Markus Perola, Iris M Heid, Christian Herder, Harald Grallert, Martina Müller-Nurasyid, Michael Roden, Elina Hypponen, Aaron Isaacs, Elisabeth M van Leeuwen, Lennart C Karssen, Evelin Mihailov, Jeanine J Houwing-Duistermaat, Anton J M de Craen, Joris Deelen, Aki S Havulinna, Matthew Blades, Christian Hengstenberg, Jeanette Erdmann, Heribert Schunkert, Jaakko Kaprio, Martin D Tobin, Nilesh J Samani, Lars Lind, Veikko Salomaa, Cecilia M Lindgren, P Eline Slagboom, Andres Metspalu, Cornelia M van Duijn, Johan G Eriksson, Annette Peters, Christian Gieger, Antti Jula, Leif Groop, Olli T Raitakari, Chris Power, Brenda W J H Penninx, Eco de Geus, Johannes H Smit, Dorret I Boomsma, Nancy L Pedersen, Erik Ingelsson, Unnur Thorsteinsdottir, Kari Stefansson, Samuli Ripatti, Inga Prokopenko, Mark I McCarthy, Andrew P Morris and Consortium Engage

Volume 11, issue 6, 2015

Leveraging Identity-by-Descent for Accurate Genotype Inference in Family Sequencing Data pp. 1-19

Bingshan Li, Qiang Wei, Xiaowei Zhan, Xue Zhong, Wei Chen, Chun Li and Jonathan Haines

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping pp. 1-22

Chris Wallace, Antony J Cutler, Nikolas Pontikos, Marcin L Pekalski, Oliver S Burren, Jason D Cooper, Arcadio Rubio García, Ricardo C Ferreira, Hui Guo, Neil M Walker, Deborah J Smyth, Stephen S Rich, Suna Onengut-Gumuscu, Stephen J Sawcer, Maria Ban, Sylvia Richardson, John A Todd and Linda S Wicker

Volume 11, issue 5, 2015

Genomic Heritability: What Is It? pp. 1-21

Gustavo de los Campos, Daniel Sorensen and Daniel Gianola

Accounting for Experimental Noise Reveals That mRNA Levels, Amplified by Post-Transcriptional Processes, Largely Determine Steady-State Protein Levels in Yeast pp. 1-32

Gábor Csárdi, Alexander Franks, David S Choi, Edoardo M Airoldi and D Allan Drummond

Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes pp. 1-12

Yann C Klimentidis, Akshay Chougule, Amit Arora, Alexis C Frazier-Wood and Chiu-Hsieh Hsu

Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature pp. 1-17

Samantha M Thomas, Courtney Kagan, Bryan J Pavlovic, Jonathan Burnett, Kristen Patterson, Jonathan K Pritchard and Yoav Gilad

Cell Specific eQTL Analysis without Sorting Cells pp. 1-17

Harm-Jan Westra, Danny Arends, Tõnu Esko, Marjolein J Peters, Claudia Schurmann, Katharina Schramm, Johannes Kettunen, Hanieh Yaghootkar, Benjamin P Fairfax, Anand Kumar Andiappan, Yang Li, Jingyuan Fu, Juha Karjalainen, Mathieu Platteel, Marijn Visschedijk, Rinse K Weersma, Silva Kasela, Lili Milani, Liina Tserel, Pärt Peterson, Eva Reinmaa, Albert Hofman, André G Uitterlinden, Fernando Rivadeneira, Georg Homuth, Astrid Petersmann, Roberto Lorbeer, Holger Prokisch, Thomas Meitinger, Christian Herder, Michael Roden, Harald Grallert, Samuli Ripatti, Markus Perola, Andrew R Wood, David Melzer, Luigi Ferrucci, Andrew B Singleton, Dena G Hernandez, Julian C Knight, Rossella Melchiotti, Bernett Lee, Michael Poidinger, Francesca Zolezzi, Anis Larbi, Wang De Yun, Leonard H van den Berg, Jan H Veldink, Olaf Rotzschke, Seiko Makino, Veikko Salomaa, Konstantin Strauch, Uwe Völker, Joyce B J van Meurs, Andres Metspalu, Cisca Wijmenga, Ritsert C Jansen and Lude Franke

The Whole of a Scientific Career: An Interview with Oliver Smithies pp. 1-9

Jane Gitschier

Volume 11, issue 4, 2015

Simultaneous Discovery, Estimation and Prediction Analysis of Complex Traits Using a Bayesian Mixture Model pp. 1-22

Gerhard Moser, Sang Hong Lee, Ben J Hayes, Michael E Goddard, Naomi R Wray and Peter M Visscher

The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease pp. 1-24

Loukas Moutsianas, Vineeta Agarwala, Christian Fuchsberger, Jason Flannick, Manuel A Rivas, Kyle J Gaulton, Patrick K Albers, GoT2D Consortium, Gil McVean, Michael Boehnke, David Altshuler and Mark I McCarthy

Multi-locus Analysis of Genomic Time Series Data from Experimental Evolution pp. 1-29

Jonathan Terhorst, Christian Schlötterer and Yun S Song

Cross-Population Joint Analysis of eQTLs: Fine Mapping and Functional Annotation pp. 1-29

Xiaoquan Wen, Francesca Luca and Roger Pique-Regi

Spatial Fluctuations in Expression of the Heterocyst Differentiation Regulatory Gene hetR in Anabaena Filaments pp. 1-21

Laura Corrales-Guerrero, Asaf Tal, Rinat Arbel-Goren, Vicente Mariscal, Enrique Flores, Antonia Herrero and Joel Stavans

Volume 11, issue 3, 2015

Reproductive Isolation of Hybrid Populations Driven by Genetic Incompatibilities pp. 1-21

Molly Schumer, Rongfeng Cui, Gil G Rosenthal and Peter Andolfatto

Selective and Genetic Constraints on Pneumococcal Serotype Switching pp. 1-21

Nicholas J Croucher, Lisa Kagedan, Claudette M Thompson, Julian Parkhill, Stephen D Bentley, Jonathan A Finkelstein, Marc Lipsitch and William P Hanage

Genome-wide Association Study and Meta-Analysis Identify ISL1 as Genome-wide Significant Susceptibility Gene for Bladder Exstrophy pp. 1-13

Markus Draaken, Michael Knapp, Tracie Pennimpede, Johanna M Schmidt, Anne-Karolin Ebert, Wolfgang Rösch, Raimund Stein, Boris Utsch, Karin Hirsch, Thomas M Boemers, Elisabeth Mangold, Stefanie Heilmann, Kerstin U Ludwig, Ekkehart Jenetzky, Nadine Zwink, Susanne Moebus, Bernhard G Herrmann, Manuel Mattheisen, Markus M Nöthen, Michael Ludwig and Heiko Reutter

Volume 11, issue 2, 2015

Recent Selective Sweeps in North American Drosophila melanogaster Show Signatures of Soft Sweeps pp. 1-32

Nandita R Garud, Philipp W Messer, Erkan O Buzbas and Dmitri A Petrov

Genomic Selection and Association Mapping in Rice (Oryza sativa): Effect of Trait Genetic Architecture, Training Population Composition, Marker Number and Statistical Model on Accuracy of Rice Genomic Selection in Elite, Tropical Rice Breeding Lines pp. 1-25

Jennifer Spindel, Hasina Begum, Deniz Akdemir, Parminder Virk, Bertrand Collard, Edilberto Redoña, Gary Atlin, Jean-Luc Jannink and Susan R McCouch

Volume 11, issue 1, 2015

An Intracellular Transcriptomic Atlas of the Giant Coenocyte Caulerpa taxifolia pp. 1-10

Aashish Ranjan, Brad T Townsley, Yasunori Ichihashi, Neelima R Sinha and Daniel H Chitwood

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus pp. 1-25

Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, Heather M Highland, Adam E Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J Gaulton, Tanya M Teslovich, N William Rayner, Neil R Robertson, Nicola L Beer, Jana K Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P Burtt, Stacey Gabriel, Anette P Gjesing, Christopher J Groves, Mette Hollensted, Jeroen R Huyghe, Anne U Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S Small, Heather M Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I Bell, John Blangero, Nancy J Cox, Ravindranath Duggirala, Craig L Hanis, Mark Seielstad, James G Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L Surdulescu, Alex S F Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D Spector, Andrew D Morris, Colin N A Palmer, Francis S Collins, Karen L Mohlke, Richard N Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C Florez, Andrew P Morris, David Altshuler, James B Meigs, Michael Boehnke, Mark I McCarthy, Cecilia M Lindgren, Anna L Gloyn and On Behalf of the T2D-GENES consortium and GoT2D consortium