PLOS Genetics

2005 - 2025

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Volume 17, issue 11, 2021

The effects of introgression across thousands of quantitative traits revealed by gene expression in wild tomatoes pp. 1-20

Mark S Hibbins and Matthew W Hahn

Network-based protein-protein interaction prediction method maps perturbations of cancer interactome pp. 1-19

Jiajun Qiu, Kui Chen, Chunlong Zhong, Sihao Zhu and Xiao Ma

Evolution of ColE1-like plasmids across γ-Proteobacteria: From bacteriocin production to antimicrobial resistance pp. 1-24

Manuel Ares-Arroyo, Eduardo P C Rocha and Bruno Gonzalez-Zorn

Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model pp. 1-25

Zhaotong Lin, Yangqing Deng and Wei Pan

Prediction of heterosis in the recent rapeseed (Brassica napus) polyploid by pairing parental nucleotide sequences pp. 1-22

Qian Wang, Tao Yan, Zhengbiao Long, Luna Yue Huang, Yang Zhu, Ying Xu, Xiaoyang Chen, Haksong Pak, Jiqiang Li, Dezhi Wu, Yang Xu, Shuijin Hua and Lixi Jiang

Volume 17, issue 10, 2021

Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset pp. 1-27

Jiwon Jeong, Jongbin Lee, Ji-hyung Kim and Chunghun Lim

Machine learning to predict the source of campylobacteriosis using whole genome data pp. 1-17

Nicolas Arning, Samuel K Sheppard, Sion Bayliss, David A Clifton and Daniel J Wilson

Haplotype associated RNA expression (HARE) improves prediction of complex traits in maize pp. 1-24

Anju Giri, Merritt Khaipho-Burch, Edward S Buckler and Guillaume P Ramstein

Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR pp. 1-37

Anna Hutchinson, Guillermo Reales, Thomas Willis and Chris Wallace

Volume 17, issue 9, 2021

Dynamic neurogenomic responses to social interactions and dominance outcomes in female paper wasps pp. 1-25

Floria M K Uy, Christopher M Jernigan, Natalie C Zaba, Eshan Mehrotra, Sara E Miller and Michael J Sheehan

A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation pp. 1-28

Payel Ganguly, Landiso Madonsela, Jesse T Chao, Christopher J R Loewen, Timothy P O’Connor, Esther M Verheyen and Douglas W Allan

A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships pp. 1-28

Richard Howey, Alexander D Clark, Najib Naamane, Louise N Reynard, Arthur G Pratt and Heather J Cordell

Identifying causal variants by fine mapping across multiple studies pp. 1-19

Nathan LaPierre, Kodi Taraszka, Helen Huang, Rosemary He, Farhad Hormozdiari and Eleazar Eskin

Genome-wide methylation data improves dissection of the effect of smoking on body mass index pp. 1-19

Carmen Amador, Yanni Zeng, Michael Barber, Rosie M Walker, Archie Campbell, Andrew M McIntosh, Kathryn L Evans, David J Porteous, Caroline Hayward, James F Wilson, Pau Navarro and Chris S Haley

Rare variants in the endocytic pathway are associated with Alzheimer’s disease, its related phenotypes, and functional consequences pp. 1-38

Lingyu Zhan, Jiajin Li, Brandon Jew and Jae Hoon Sul

A more accurate method for colocalisation analysis allowing for multiple causal variants pp. 1-11

Chris Wallace

Volume 17, issue 8, 2021

Multitrait GWAS to connect disease variants and biological mechanisms pp. 1-36

Hanna Julienne, Vincent Laville, Zachary R McCaw, Zihuai He, Vincent Guillemot, Carla Lasry, Andrey Ziyatdinov, Cyril Nerin, Amaury Vaysse, Pierre Lechat, Hervé Ménager, Wilfried Le Goff, Marie-Pierre Dube, Peter Kraft, Iuliana Ionita-Laza, Bjarni J Vilhjálmsson and Hugues Aschard

Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data pp. 1-26

Ciarrah Barry, Junxi Liu, Rebecca Richmond, Martin K Rutter, Deborah A Lawlor, Frank Dudbridge and Jack Bowden

Average semivariance yields accurate estimates of the fraction of marker-associated genetic variance and heritability in complex trait analyses pp. 1-27

Mitchell J Feldmann, Hans-Peter Piepho, William C Bridges and Steven J Knapp

Forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas protegens pp. 1-24

Jennifer T Pentz and Peter A Lind

Volume 17, issue 7, 2021

Meiosis in Quarantine discussions lead to an action plan to increase diversity and inclusion within the genetics community pp. 1-11

Katherine K Billmyre, María Angélica Bravo Núñez, Douglas K Bishop and Francesca Cole

A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics pp. 1-17

Geyu Zhou and Hongyu Zhao

A spectral theory for Wright’s inbreeding coefficients and related quantities pp. 1-24

Olivier François and Clément Gain

Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios pp. 1-28

Debashree Ray, Sowmya Venkataraghavan, Wanying Zhang, Elizabeth J Leslie, Jacqueline B Hetmanski, Seth M Weinberg, Jeffrey C Murray, Mary L Marazita, Ingo Ruczinski, Margaret A Taub and Terri H Beaty

Volume 17, issue 6, 2021

An autoregulatory negative feedback loop controls thermomorphogenesis in Arabidopsis pp. 1-21

Sanghwa Lee, Ling Zhu and Enamul Huq

A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor pp. 1-13

Harry D Green, Alistair Jones, Jonathan P Evans, Andrew R Wood, Robin N Beaumont, Jessica Tyrrell, Timothy M Frayling, Christopher Smith and Michael N Weedon

Predicting population genetic change in an autocorrelated random environment: Insights from a large automated experiment pp. 1-23

Marie Rescan, Daphné Grulois, Enrique Ortega Aboud, Pierre de Villemereuil and Luis-Miguel Chevin

Volume 17, issue 5, 2021

Evolution of plasticity in production and transgenerational inheritance of small RNAs under dynamic environmental conditions pp. 1-25

Willian T A F Silva, Sarah P Otto and Simone Immler

Evaluation of polygenic prediction methodology within a reference-standardized framework pp. 1-22

Oliver Pain, Kylie P Glanville, Saskia P Hagenaars, Saskia Selzam, Anna E Fürtjes, Héléna A Gaspar, Jonathan R I Coleman, Kaili Rimfeld, Gerome Breen, Robert Plomin, Lasse Folkersen and Cathryn M Lewis

Gene action, genetic variation, and GWAS: A user-friendly web tool pp. 1-9

Valentin Hivert, Naomi R Wray and Peter M Visscher

Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images pp. 1-27

Hannah Currant, Pirro Hysi, Tomas W Fitzgerald, Puya Gharahkhani, Pieter W M Bonnemaijer, Anne Senabouth, Alex W Hewitt, UK Biobank Eye and Vision Consortium, International Glaucoma Genetics Consortium, Denize Atan, Tin Aung, Jason Charng, Hélène Choquet, Jamie Craig, Peng T Khaw, Caroline C W Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R Pasquale, Charles A Reisman, Maciej Daniszewski, Joseph E Powell, Alice Pébay, Mark J Simcoe, Alberta A H J Thiadens, Cornelia M van Duijn, Seyhan Yazar, Eric Jorgenson, Stuart MacGregor, Chris J Hammond, David A Mackey, Janey L Wiggs, Paul J Foster, Praveen J Patel, Ewan Birney and Anthony P Khawaja

Volume 17, issue 4, 2021

Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies pp. 1-21

Helian Feng, Nicholas Mancuso, Alexander Gusev, Arunabha Majumdar, Megan Major, Bogdan Pasaniuc and Peter Kraft

MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity pp. 1-24

Anqi Zhu, Nana Matoba, Emma P Wilson, Amanda L Tapia, Yun Li, Joseph G Ibrahim, Jason L Stein and Michael I Love

Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank pp. 1-27

Keira J A Johnston, Joey Ward, Pradipta R Ray, Mark J Adams, Andrew M McIntosh, Blair H Smith, Rona J Strawbridge, Theodore J Price, Daniel J Smith, Barbara I Nicholl and Mark E S Bailey

Volume 17, issue 3, 2021

Changes in the fine-scale genetic structure of Finland through the 20th century pp. 1-26

Sini Kerminen, Nicola Cerioli, Darius Pacauskas, Aki S Havulinna, Markus Perola, Pekka Jousilahti, Veikko Salomaa, Mark J Daly, Rupesh Vyas, Samuli Ripatti and Matti Pirinen

MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies pp. 1-30

Arjun Bhattacharya, Yun Li and Michael I Love

Genome-wide association study of fish oil supplementation on lipid traits in 81,246 individuals reveals new gene-diet interaction loci pp. 1-20

Michael Francis, Changwei Li, Yitang Sun, Jingqi Zhou, Xiang Li, J Thomas Brenna and Kaixiong Ye

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers pp. 1-19

Corina Lesseur, Aida Ferreiro-Iglesias, James D McKay, Yohan Bossé, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C Christiani, Neil C Caporaso, Stig E Bojesen, Christopher I Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrius Albanes, Melinda C Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K Field, Marion Dawn Teare, Lambertus A Kiemeney, Brenda Diergaarde, Robert L Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F Olshan, Mark C Weissler, Martin Lacko, Angela Risch, Heike Bickeböller, Andy R Ness, Steve Thomas, Loic Le Marchand, Matthew B Schabath, Victor Wünsch-Filho, Eloiza H Tajara, Angeline S Andrew, Gary M Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnström, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma’en Obeidat, Xiangjun Xiao, Richard S Houlston, Rayjean J Hung and Paul Brennan

Volume 17, issue 2, 2021

Power analysis of transcriptome-wide association study: Implications for practical protocol choice pp. 1-20

Chen Cao, Bowei Ding, Qing Li, Devin Kwok, Jingjing Wu and Quan Long

Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease pp. 1-22

Nana Liu, Jiayuan Xu, Huaigui Liu, Shijie Zhang, Miaoxin Li, Yao Zhou, Wen Qin, Mulin Jun Li, Chunshui Yu and for the Alzheimer’s disease Neuroimaging Initiative

Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder pp. 1-25

Kunling Huang, Yuchang Wu, Junha Shin, Ye Zheng, Alireza Fotuhi Siahpirani, Yupei Lin, Zheng Ni, Jiawen Chen, Jing You, Sunduz Keles, Daifeng Wang, Sushmita Roy and Qiongshi Lu

Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles pp. 1-28

Kathryn A Jewett, Ruth E Thomas, Chi Q Phan, Bernice Lin, Gillian Milstein, Selina Yu, Lisa F Bettcher, Fausto Carnevale Neto, Danijel Djukovic, Daniel Raftery, Leo J Pallanck and Marie Y Davis

Volume 17, issue 1, 2021

Estimating FST and kinship for arbitrary population structures pp. 1-36

Alejandro Ochoa and John D Storey

Accurate genetic and environmental covariance estimation with composite likelihood in genome-wide association studies pp. 1-25

Boran Gao, Can Yang, Jin Liu and Xiang Zhou

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome pp. 1-26

Denis A Baird, Jimmy Z Liu, Jie Zheng, Solveig K Sieberts, Thanneer Perumal, Benjamin Elsworth, Tom G Richardson, Chia-Yen Chen, Minerva M Carrasquillo, Mariet Allen, Joseph S Reddy, Philip L De Jager, Nilufer Ertekin-Taner, Lara M Mangravite, Ben Logsdon, Karol Estrada, Philip C Haycock, Gibran Hemani, Heiko Runz, George Davey Smith, Tom R Gaunt and eQTL working group Amp-Ad

Ciona Brachyury proximal and distal enhancers have different FGF dose-response relationships pp. 1-23

Matthew J Harder, Julie Hix, Wendy M Reeves and Michael T Veeman

Adaptation is influenced by the complexity of environmental change during evolution in a dynamic environment pp. 1-27

Sébastien Boyer, Lucas Hérissant and Gavin Sherlock

Population structure of indigenous inhabitants of Arabia pp. 1-18

Katsuhiko Mineta, Kosuke Goto, Takashi Gojobori and Fowzan S Alkuraya

Volume 16, issue 12, 2020

Super-resolution visualization of distinct stalled and broken replication fork structures pp. 1-28

Donna R Whelan, Wei Ting C Lee, Frances Marks, Yu Tina Kong, Yandong Yin and Eli Rothenberg

Integrating comprehensive functional annotations to boost power and accuracy in gene-based association analysis pp. 1-23

Corbin Quick, Xiaoquan Wen, Gonçalo Abecasis, Michael Boehnke and Hyun Min Kang

Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies pp. 1-15

Robin N Beaumont, Sarah J Kotecha, Andrew R Wood, Bridget A Knight, Sylvain Sebert, Mark I McCarthy, Andrew T Hattersley, Marjo-Riitta Järvelin, Nicholas J Timpson, Rachel M Freathy and Sailesh Kotecha

Volume 16, issue 11, 2020

Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency pp. 1-24

Federica Diofano, Karolina Weinmann, Isabelle Schneider, Kevin D Thiessen, Wolfgang Rottbauer and Steffen Just

LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanks pp. 1-23

Jeffery A Goldstein, Joshua S Weinstock, Lisa A Bastarache, Daniel B Larach, Lars G Fritsche, Ellen M Schmidt, Chad M Brummett, Sachin Kheterpal, Goncalo R Abecasis, Joshua C Denny and Matthew Zawistowski

Genotype imputation using the Positional Burrows Wheeler Transform pp. 1-19

Simone Rubinacci, Olivier Delaneau and Jonathan Marchini

Multivariable G-E interplay in the prediction of educational achievement pp. 1-20

Andrea G Allegrini, Ville Karhunen, Jonathan R I Coleman, Saskia Selzam, Kaili Rimfeld, Sophie von Stumm, Jean-Baptiste Pingault and Robert Plomin

Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data pp. 1-30

Haoran Xue and Wei Pan

Volume 16, issue 10, 2020

Selection for ancient periodic motifs that do not impart DNA bending pp. 1-25

Aletheia Atzinger and Jeffrey G Lawrence

By what name shall I call thee? pp. 1-2

Gregory S Barsh and Gregory P Copenhaver

Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms pp. 1-22

Xinyue Li and Hongyu Zhao

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits pp. 1-26

Suzanne Vogelezang, Jonathan P Bradfield, Tarunveer S Ahluwalia, John A Curtin, Timo A Lakka, Niels Grarup, Markus Scholz, Peter J van der Most, Claire Monnereau, Evie Stergiakouli, Anni Heiskala, Momoko Horikoshi, Iryna O Fedko, Natalia Vilor-Tejedor, Diana L Cousminer, Marie Standl, Carol A Wang, Jorma Viikari, Frank Geller, Carmen Íñiguez, Niina Pitkänen, Alessandra Chesi, Jonas Bacelis, Loic Yengo, Maties Torrent, Ioanna Ntalla, Øyvind Helgeland, Saskia Selzam, Judith M Vonk, Mohammed H Zafarmand, Barbara Heude, Ismaa Sadaf Farooqi, Akram Alyass, Robin N Beaumont, Christian T Have, Peter Rzehak, Jose Ramon Bilbao, Theresia M Schnurr, Inês Barroso, Klaus Bønnelykke, Lawrence J Beilin, Lisbeth Carstensen, Marie-Aline Charles, Bo Chawes, Karine Clément, Ricardo Closa-Monasterolo, Adnan Custovic, Johan G Eriksson, Joaquin Escribano, Maria Groen-Blokhuis, Veit Grote, Dariusz Gruszfeld, Hakon Hakonarson, Torben Hansen, Andrew T Hattersley, Mette Hollensted, Jouke-Jan Hottenga, Elina Hyppönen, Stefan Johansson, Raimo Joro, Mika Kähönen, Ville Karhunen, Wieland Kiess, Bridget A Knight, Berthold Koletzko, Andreas Kühnapfel, Kathrin Landgraf, Jean-Paul Langhendries, Terho Lehtimäki, Jaakko T Leinonen, Aihuali Li, Virpi Lindi, Estelle Lowry, Mariona Bustamante, Carolina Medina-Gomez, Mads Melbye, Kim F Michaelsen, Camilla S Morgen, Trevor A Mori, Tenna R H Nielsen, Harri Niinikoski, Albertine J Oldehinkel, Katja Pahkala, Kalliope Panoutsopoulou, Oluf Pedersen, Craig E Pennell, Christine Power, Sijmen A Reijneveld, Fernando Rivadeneira, Angela Simpson, Peter D Sly, Jakob Stokholm, Kook K Teo, Elisabeth Thiering, Nicholas J Timpson, André G Uitterlinden, Catharina E M van Beijsterveldt, Barbera D C van Schaik, Marc Vaudel, Elvira Verduci, Rebecca K Vinding, Mandy Vogel, Eleftheria Zeggini, Sylvain Sebert, Mads V Lind, Christopher D Brown, Loreto Santa-Marina, Eva Reischl, Christine Frithioff-Bøjsøe, David Meyre, Eleanor Wheeler, Ken Ong, Ellen A Nohr, Tanja G M Vrijkotte, Gerard H Koppelman, Robert Plomin, Pål R Njølstad, George D Dedoussis, Philippe Froguel, Thorkild I A Sørensen, Bo Jacobsson, Rachel M Freathy, Babette S Zemel, Olli Raitakari, Martine Vrijheid, Bjarke Feenstra, Leo-Pekka Lyytikäinen, Harold Snieder, Holger Kirsten, Patrick G Holt, Joachim Heinrich, Elisabeth Widén, Jordi Sunyer, Dorret I Boomsma, Marjo-Riitta Järvelin, Antje Körner, George Davey Smith, Jens-Christian Holm, Mustafa Atalay, Clare Murray, Hans Bisgaard, Mark I McCarthy, Early Growth Genetics Consortium, Vincent W V Jaddoe, Struan F A Grant and Janine F Felix

A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices pp. 1-23

James A Watson, Aimee R Taylor, Elizabeth A Ashley, Arjen Dondorp, Caroline O Buckee, Nicholas J White and Chris C Holmes

Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation pp. 1-21

Brendan Evano, Diljeet Gill, Irene Hernando-Herraez, Glenda Comai, Thomas M Stubbs, Pierre-Henri Commere, Wolf Reik and Shahragim Tajbakhsh

AKH-FOXO pathway regulates starvation-induced sleep loss through remodeling of the small ventral lateral neuron dorsal projections pp. 1-21

Qiankun He, Juan Du, Liya Wei and Zhangwu Zhao

A fast and scalable framework for large-scale and ultrahigh-dimensional sparse regression with application to the UK Biobank pp. 1-30

Junyang Qian, Yosuke Tanigawa, Wenfei Du, Matthew Aguirre, Chris Chang, Robert Tibshirani, Manuel A Rivas and Trevor Hastie

Volume 16, issue 9, 2020

Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts pp. 1-35

Jie Yuan, Henry Xing, Alexandre Louis Lamy, The Schizophrenia Working Group of the Psychiatric Genomics Consortium, Todd Lencz and Itsik Pe’er

Restriction on self-renewing asymmetric division is coupled to terminal asymmetric division in the Drosophila CNS pp. 1-27

Ivana Gaziova, Michael Gazi, Jordan Mar and Krishna Moorthi Bhat

The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance pp. 1-23

Zong Miao, Marcus Alvarez, Arthur Ko, Yash Bhagat, Elior Rahmani, Brandon Jew, Sini Heinonen, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Carlos Aguilar-Salinas, Teresa Tusie-Luna, Karen L Mohlke, Markku Laakso, Kirsi H Pietiläinen, Eran Halperin and Päivi Pajukanta

Volume 16, issue 8, 2020

On the cross-population generalizability of gene expression prediction models pp. 1-28

Kevin L Keys, Angel C Y Mak, Marquitta J White, Walter L Eckalbar, Andrew W Dahl, Joel Mefford, Anna V Mikhaylova, María G Contreras, Jennifer R Elhawary, Celeste Eng, Donglei Hu, Scott Huntsman, Sam S Oh, Sandra Salazar, Michael A Lenoir, Jimmie C Ye, Timothy A Thornton, Noah Zaitlen, Esteban G Burchard and Christopher R Gignoux

A general framework for functionally informed set-based analysis: Application to a large-scale colorectal cancer study pp. 1-21

Xinyuan Dong, Yu-Ru Su, Richard Barfield, Stephanie A Bien, Qianchuan He, Tabitha A Harrison, Jeroen R Huyghe, Temitope O Keku, Noralane M Lindor, Clemens Schafmayer, Andrew T Chan, Stephen B Gruber, Mark A Jenkins, Charles Kooperberg, Ulrike Peters and Li Hsu

Cryptic genetic variation enhances primate L1 retrotransposon survival by enlarging the functional coiled coil sequence space of ORF1p pp. 1-19

Anthony V Furano, Charlie E Jones, Vipul Periwal, Kathryn E Callahan, Jean-Claude Walser and Pamela R Cook

Pan-genomic open reading frames: A potential supplement of single nucleotide polymorphisms in estimation of heritability and genomic prediction pp. 1-19

Zhengcao Li and Henner Simianer

Learning the properties of adaptive regions with functional data analysis pp. 1-44

Mehreen R Mughal, Hillary Koch, Jinguo Huang, Francesca Chiaromonte and Michael DeGiorgio

Volume 16, issue 7, 2020

Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits pp. 1-24

Andrew D Bretherick, Oriol Canela-Xandri, Peter K Joshi, David W Clark, Konrad Rawlik, Thibaud S Boutin, Yanni Zeng, Carmen Amador, Pau Navarro, Igor Rudan, Alan F Wright, Harry Campbell, Veronique Vitart, Caroline Hayward, James F Wilson, Albert Tenesa, Chris P Ponting, J Kenneth Baillie and Chris Haley

Unified inference of missense variant effects and gene constraints in the human genome pp. 1-24

Yi-Fei Huang

Mixed methods pp. 1-2

David J Balding, Gregory S Barsh, Gregory P Copenhaver and Chengqi Yi

Volume 16, issue 6, 2020

A Bayesian method to estimate variant-induced disease penetrance pp. 1-16

Brett M Kroncke, Derek K Smith, Yi Zuo, Andrew M Glazer, Dan M Roden and Jeffrey D Blume

Protein-protein interaction network controlling establishment and maintenance of switchable cell polarity pp. 1-30

Luís António Menezes Carreira, Filipe Tostevin, Ulrich Gerland and Lotte Søgaard-Andersen

Volume 16, issue 5, 2020

Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model pp. 1-30

Dominic Holland, Oleksandr Frei, Rahul Desikan, Chun-Chieh Fan, Alexey A Shadrin, Olav B Smeland, V S Sundar, Paul Thompson, Ole A Andreassen and Anders M Dale

Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae pp. 1-28

Davide Marchi, Kirankumar Santhakumar, Eleanor Markham, Nan Li, Karl-Heinz Storbeck, Nils Krone, Vincent T Cunliffe and Fredericus J M van Eeden

Trans-ethnic meta-analysis of genome-wide association studies identifies maternal ITPR1 as a novel locus influencing fetal growth during sensitive periods in pregnancy pp. 1-20

Fasil Tekola-Ayele, Cuilin Zhang, Jing Wu, Katherine L Grantz, Mohammad L Rahman, Deepika Shrestha, Marion Ouidir, Tsegaselassie Workalemahu and Michael Y Tsai

Scalable probabilistic PCA for large-scale genetic variation data pp. 1-19

Aman Agrawal, Alec M Chiu, Minh Le, Eran Halperin and Sriram Sankararaman

Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models pp. 1-25

Sahir R Bhatnagar, Yi Yang, Tianyuan Lu, Erwin Schurr, Loredo-Osti Jc, Marie Forest, Karim Oualkacha and Celia M T Greenwood

Volume 16, issue 4, 2020

Technical and social issues influencing the adoption of preprints in the life sciences pp. 1-16

Naomi C Penfold and Jessica K Polka

Leveraging gene co-expression patterns to infer trait-relevant tissues in genome-wide association studies pp. 1-30

Lulu Shang, Jennifer A Smith and Xiang Zhou

Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses pp. 1-20

Chris Wallace

Volume 16, issue 3, 2020

The influence of rare variants in circulating metabolic biomarkers pp. 1-19

Fernando Riveros-Mckay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, Study Interval, Eleanor Wheeler, Eleftheria Zeggini, Adam S Butterworth and Inês Barroso

Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study pp. 1-19

Yao Hu, Mariaelisa Graff, Jeffrey Haessler, Steven Buyske, Stephanie A Bien, Ran Tao, Heather M Highland, Katherine K Nishimura, Niha Zubair, Yingchang Lu, Marie Verbanck, Austin T Hilliard, Derek Klarin, Scott M Damrauer, Yuk-Lam Ho, the VA Million Veteran Program, Peter W F Wilson, Kyong-Mi Chang, Philip S Tsao, Kelly Cho, Christopher J O’Donnell, Themistocles L Assimes, Lauren E Petty, Jennifer E Below, Ozan Dikilitas, Daniel J Schaid, Matthew L Kosel, Iftikhar J Kullo, Laura J Rasmussen-Torvik, Gail P Jarvik, Qiping Feng, Wei-Qi Wei, Eric B Larson, Frank D Mentch, Berta Almoguera, Patrick M Sleiman, Laura M Raffield, Adolfo Correa, Lisa W Martin, Martha Daviglus, Tara C Matise, Jose Luis Ambite, Christopher S Carlson, Ron Do, Ruth J F Loos, Lynne R Wilkens, Loic Le Marchand, Chris Haiman, Daniel O Stram, Lucia A Hindorff, Kari E North, Charles Kooperberg, Iona Cheng and Ulrike Peters

Pleiotropy facilitates local adaptation to distant optima in common ragweed (Ambrosia artemisiifolia) pp. 1-23

Tuomas Hämälä, Amanda J Gorton, David A Moeller and Peter Tiffin

Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity pp. 1-26

Elizabeth B Brown, Kreesha D Shah, Richard Faville, Benjamin Kottler and Alex C Keene

Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data pp. 1-35

Richard Howey, So-Youn Shin, Caroline Relton, George Davey Smith and Heather J Cordell

A Snf1-related nutrient-responsive kinase antagonizes endocytosis in yeast pp. 1-40

Jessica M Tumolo, Nathaniel L Hepowit, Samika S Joshi and Jason A MacGurn

Volume 16, issue 2, 2020

A molecular barcode to inform the geographical origin and transmission dynamics of Plasmodium vivax malaria pp. 1-19

Ernest Diez Benavente, Monica Campos, Jody Phelan, Debbie Nolder, Jamille G Dombrowski, Claudio R F Marinho, Kanlaya Sriprawat, Aimee R Taylor, James Watson, Cally Roper, Francois Nosten, Colin J Sutherland, Susana Campino and Taane G Clark

Volume 16, issue 1, 2020

High-throughput discovery of genetic determinants of circadian misalignment pp. 1-25

Tao Zhang, Pancheng Xie, Yingying Dong, Zhiwei Liu, Fei Zhou, Dejing Pan, Zhengyun Huang, Qiaocheng Zhai, Yue Gu, Qingyu Wu, Nobuhiko Tanaka, Yuichi Obata, Allan Bradley, Christopher J Lelliott, Sanger Institute Mouse Genetics Project, Lauryl M J Nutter, Colin McKerlie, Ann M Flenniken, Marie-France Champy, Tania Sorg, Yann Herault, Martin Hrabe De Angelis, Valerie Gailus Durner, Ann-Marie Mallon, Steve D M Brown, Terry Meehan, Helen E Parkinson, Damian Smedley, K C Kent Lloyd, Jun Yan, Xiang Gao, Je Kyung Seong, Chi-Kuang Leo Wang, Radislav Sedlacek, Yi Liu, Jan Rozman, Ling Yang and Ying Xu

The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders pp. 1-17

Mette K Andersen, Emil Jørsboe, Line Skotte, Kristian Hanghøj, Camilla H Sandholt, Ida Moltke, Niels Grarup, Timo Kern, Yuvaraj Mahendran, Bolette Søborg, Peter Bjerregaard, Christina V L Larsen, Inger K Dahl-Petersen, Hemant K Tiwari, Bjarke Feenstra, Anders Koch, Howard W Wiener, Scarlett E Hopkins, Oluf Pedersen, Mads Melbye, Bert B Boyer, Marit E Jørgensen, Anders Albrechtsen and Torben Hansen