Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Bolton, Jennifer L; Hayward, Caroline; Direk, Nese; Lewis, John G; Hammond, Geoffrey L; Hill, Lesley A; Anderson, Anna; Huffman, Jennifer; Wilson, James F; Campbell, Harry; Rudan, Igor; Wright, Alan; Hastie, Nicholas; Wild, Sarah H; Velders, Fleur P; Hofman, Albert; Uitterlinden, Andre G; Lahti, Jari; Räikkönen, Katri; Kajantie, Eero; Widen, Elisabeth; Palotie, Aarno; Eriksson, Johan G; Kaakinen, Marika; Järvelin, Marjo-Riitta; Timpson, Nicholas J; Smith, George Davey; Ring, Susan M; Evans, Martin; Pourcain, Beate St; Tanaka, Toshiko; Milaneschi, Yuri; Bandinelli, Stefania; Ferrucci, Luigi; van der Harst, Pim; Rosmalen, Judith G M; Bakker, Stephen J L; Verweij, Niek; Dullaart, Robin P F; Mahajan, Anubha; Lindgren, Cecilia M; Morris, Andrew; Lind, Lars; Ingelsson, Erik; Anderson, Laura N; Pennell, Craig E; Lye, Stephen J; Matthews, Stephen G; Eriksson, Joel; Mellstrom, Dan; Ohlsson, Claes; Price, Jackie F; Strachan, Mark W J; Reynolds, Rebecca M; Tiemeier, Henning; Walker, Brian R; Consortium, on behalf of the CORtisol NETwork (CORNET)

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Jennifer L Bolton, Caroline Hayward, Nese Direk, John G Lewis, Geoffrey L Hammond, Lesley A Hill, Anna Anderson, Jennifer Huffman, James F Wilson, Harry Campbell, Igor Rudan, Alan Wright, Nicholas Hastie, Sarah H Wild, Fleur P Velders, Albert Hofman, Andre G Uitterlinden, Jari Lahti, Katri Räikkönen, Eero Kajantie, Elisabeth Widen, Aarno Palotie, Johan G Eriksson, Marika Kaakinen, Marjo-Riitta Järvelin, Nicholas J Timpson, George Davey Smith, Susan M Ring, Martin Evans, Beate St Pourcain, Toshiko Tanaka, Yuri Milaneschi, Stefania Bandinelli, Luigi Ferrucci, Pim van der Harst, Judith G M Rosmalen, Stephen J L Bakker, Niek Verweij, Robin P F Dullaart, Anubha Mahajan, Cecilia M Lindgren, Andrew Morris, Lars Lind, Erik Ingelsson, Laura N Anderson, Craig E Pennell, Stephen J Lye, Stephen G Matthews, Joel Eriksson, Dan Mellstrom, Claes Ohlsson, Jackie F Price, Mark W J Strachan, Rebecca M Reynolds, Henning Tiemeier, Brian R Walker and on behalf of the CORtisol NETwork (CORNET) Consortium

PLOS Genetics, 2014, vol. 10, issue 7, 1-11

Abstract: Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30–60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1004474

DOI: 10.1371/journal.pgen.1004474

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