A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

Eleonora A M Festen, Philippe Goyette, Todd Green, Gabrielle Boucher, Claudine Beauchamp, Gosia Trynka, Patrick C Dubois, Caroline Lagacé, Pieter C F Stokkers, Daan W Hommes, Donatella Barisani, Orazio Palmieri, Vito Annese, David A van Heel, Rinse K Weersma, Mark J Daly, Cisca Wijmenga and John D Rioux

PLOS Genetics, 2011, vol. 7, issue 1, 1-6

Abstract: Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general population. These observations suggest that CD and CelD may share common genetic risk loci. Two such shared loci, IL18RAP and PTPN2, have already been identified independently in these two diseases. The aim of our study was to explicitly identify shared risk loci for these diseases by combining results from genome-wide association study (GWAS) datasets of CD and CelD. Specifically, GWAS results from CelD (768 cases, 1,422 controls) and CD (3,230 cases, 4,829 controls) were combined in a meta-analysis. Nine independent regions had nominal association p-value

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1001283

DOI: 10.1371/journal.pgen.1001283

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