Genome-Wide Association Studies of the PR Interval in African Americans

Smith, J Gustav; Magnani, Jared W; Palmer, Cameron; Meng, Yan A; Soliman, Elsayed Z; Musani, Solomon K; Kerr, Kathleen F; Schnabel, Renate B; Lubitz, Steven A; Sotoodehnia, Nona; Redline, Susan; Pfeufer, Arne; Müller, Martina; Evans, Daniel S; Nalls, Michael A; Liu, Yongmei; Newman, Anne B; Zonderman, Alan B; Evans, Michele K; Deo, Rajat; Ellinor, Patrick T; Paltoo, Dina N; Newton-Cheh, Christopher; Benjamin, Emelia J; Mehra, Reena; Alonso, Alvaro; Heckbert, Susan R; Fox, Ervin R; Consortium, Candidate-gene Association Resource (CARe)

Genome-Wide Association Studies of the PR Interval in African Americans

J Gustav Smith, Jared W Magnani, Cameron Palmer, Yan A Meng, Elsayed Z Soliman, Solomon K Musani, Kathleen F Kerr, Renate B Schnabel, Steven A Lubitz, Nona Sotoodehnia, Susan Redline, Arne Pfeufer, Martina Müller, Daniel S Evans, Michael A Nalls, Yongmei Liu, Anne B Newman, Alan B Zonderman, Michele K Evans, Rajat Deo, Patrick T Ellinor, Dina N Paltoo, Christopher Newton-Cheh, Emelia J Benjamin, Reena Mehra, Alvaro Alonso, Susan R Heckbert, Ervin R Fox and Candidate-gene Association Resource (CARe) Consortium

PLOS Genetics, 2011, vol. 7, issue 2, 1-9

Abstract: The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races. Genome-wide association (GWA) studies have identified common genetic determinants of the PR interval in individuals of European and Asian ancestry, but there is a general paucity of GWA studies in individuals of African ancestry. We performed GWA studies in African American individuals from four cohorts (n = 6,247) to identify genetic variants associated with PR interval duration. Genotyping was performed using the Affymetrix 6.0 microarray. Imputation was performed for 2.8 million single nucleotide polymorphisms (SNPs) using combined YRI and CEU HapMap phase II panels. We observed a strong signal (rs3922844) within the gene encoding the cardiac sodium channel (SCN5A) with genome-wide significant association (p

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1001304

DOI: 10.1371/journal.pgen.1001304

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